The Botswana High is a prominent mid-tropospheric system that modulates rainfall over subtropical southern Africa, but the capability of a Global Climate Model (GCM) to reproduce it remains unknown. This study examines the capability of a GCM with quasi-uniform resolution (Model Prediction Across Scales, hereafter MPAS) in simulating the characteristics of the Botswana High. The MPAS is applied to simulate the global climate at 240km quasi-uniform resolution over the globe for the period 1980-2010. The model results are validated against gridded observation dataset (Climate Research Unit, CRU), satellite dataset (Global Precipitation Climatology Project, GPCP), and reanalysis datasets (Climate Forecast System Reanalysis, CFSR; the National Oceanic and Atmospheric Administration, NOAA; and the European Centre for Medium-Range Weather Forecasts version 5, ERA5). In general, MPAS replicates all the essential features in the climatology of temperature, rainfall, 500 hPa geopotential height and vertical motion over southern Africa, reproduces the spatial and temporal variation of the Botswana High, and captures the in uence of the Botswana High on droughts and deep convections over the sub-continent. In addition, the model reproduces well the anomalies in vertical motion over subtropical southern Africa during +ve and -ve phases of the Botswana High. However, the model struggles to reproduce the precipitation pattern associated with the positive and native modes of Botswana high. The results of this study have an application in understanding the characteristics of Botswana High and in improving MPAS for seasonal forecasting over southern Africa.