Assessment of mutagenicity caused by popular baby foods and baby plastic-ware products: An imperative study using microbial bioassays and migration analysis

Nepalia, Amrita; Singh, Anuradha; Mathur, Nupur; Kamath, Rajashree; Pareek, Sushila

doi:10.1016/j.ecoenv.2018.07.002

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…It should be noted that the exposure risk decreases with individual age [22]. PAEs do not show mutagenic and/or genotoxic activity [27], although a recent study shows potentially surprising mutagenic activity by DEHP [28], whereas the carcinogenic aspect is more complex [29]. DEP activity is questionable, there are no carcinogenicity data available for DiNP, DBP appears to be associated with tumor promotion activity, and DEHP exposure produces hepatocellular carcinoma in rodents along with a variety of other hepatocellular effects [30].…”

Section: Introductionmentioning

confidence: 99%

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

et al. 2019

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Phthalates (or phthalate esters, PAEs) and bisphenol A (BPA) are widely used in various industries, particularly in the fields of cosmetics and packaging, and they increase the malleability and workability of materials. As a result of their use, some international health organizations have begun to study them. In this study, the authors developed a methodology for the simultaneous determination of dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP); dibutyl phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP); di-n-octyl-phthalate (DnOP) and bisphenol A (BPA) from drinking and non-potable waters. The extraction of PAEs and BPA was performed using a solvent-based dispersive liquid–liquid microextraction (SB-DLLME) method. The analytical determination was performed using a gas chromatography–ion trap mass spectrometry (GC-IT/MS) analysis. The entire procedure was validated as recoveries were studied according to the volume and the extraction solvent used, pH, and ionic strength. Dynamic linearity ranges and linear equations of all the compounds were experimentally determined as well as the limit of detection (LOD) (1–8 ng mL−1) and the limit of quantification (LOQ) (5–14 ng mL−1), reproducibility, and sensitivity. The method was applied to 15 water samples (mineral water and tap water) for determining PAEs and BPA released from the plastic container. After the release simulation, four PAEs (i.e., DiBP, DBP, DHEP, and DnOP) were determined at very low concentrations (below 1.2 ng mL−1) in two water samples from (sport) bottles.

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Section: Introductionmentioning

confidence: 99%

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

et al. 2019

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“…These values represent the temperature at which food is usually added to these plastic samples. According to the results, some of the baby bottles were significantly characterized as mutagenic due to the high concentration of BPA [43].…”

Section: Migration Testing Proceduresmentioning

confidence: 99%

“…The filtrate was analyzed in an HPLC-MS chromatographic system. According to the results, considering that baby foods are prepared at 45 • C, a 4.5 kg infant who consumes about 700 mL of milk per day is expected to receive 0.007 mg BPA/kg body weight each day [43].…”

Section: Sample Preparation Techniques For the Determination Of Bpa I...mentioning

confidence: 99%

Βisphenol A and its analogs migrated from contact materials into food and beverages: An updated review in sample preparation approaches

Priovolos

Samanidou

2023

J of Separation Science

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Bisphenols are used as monomers in the production of plastic materials, and they are likely to be detected in food contact materials. Due to their migration from these plastic packaging materials into food and beverages, the organoleptic properties of the products are changing and plenty of harmful effects on human health are caused, especially if consumers are exposed to higher levels of bisphenols than those established by legislation. However, because of their trace‐level presence, their determination into food and beverage matrices is rather difficult. For this reason, sensitive, simple, rapid, and green methods are required to extract and preconcentrate the analytes of interest. Effective and representative tests are required as well, to evaluate the migration of bisphenols from plastic materials under realistic usage conditions. This review provides a detailed background of bisphenol A chemistry and legislation. Furthermore, it refers to bisphenol A migration test procedures and the recent advances of the last decade in the extraction of bisphenols from various matrices by using different sample preparation techniques prior to their chromatographic determination.

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“…BPA can get into food and beverages stored in containers made of it. The factors that increase the release of BPA are low pH, elevated temperature, repeated use of containers and the chemical properties of stored substances [ 6 , 7 ]. As a result, it is detected in the human urine, serum of pregnant women, amniotic fluid, breast milk, umbilical cord blood and other body fluids [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Removal by the Fungus Myrothecium roridumIM 6482—Analysis of the Cellular and Subcellular Level

Jasińska

Soboń²,

Różalska

et al. 2021

IJMS

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Bisphenol (BPA) is a key ingredient in the production of epoxy resins and some types of plastics, which can be released into the environment and alter the endocrine systems of wildlife and humans. In this study, the ability of the fungus M. roridumIM 6482 to BPA elimination was investigated. LC-MS/MS analysis showed almost complete removal of BPA from the growth medium within 72 h of culturing. Products of BPA biotransformation were identified, and their estrogenic activity was found to be lower than that of the parent compound. Extracellular laccase activity was identified as the main mechanism of BPA elimination. It was observed that BPA induced oxidative stress in fungal cells manifested as the enhancement in ROS production, membranes permeability and lipids peroxidation. These oxidative stress markers were reduced after BPA biodegradation (72 h of culturing). Intracellular proteome analyses performed using 2-D electrophoresis and MALDI-TOF/TOF technique allowed identifying 69 proteins in a sample obtained from the BPA containing culture. There were mainly structural and regulator proteins but also oxidoreductive and antioxidative agents, such as superoxide dismutase and catalase. The obtained results broaden the knowledge on BPA elimination by microscopic fungi and may contribute to the development of BPA biodegradation methods.

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Assessment of mutagenicity caused by popular baby foods and baby plastic-ware products: An imperative study using microbial bioassays and migration analysis

Cited by 7 publications

References 25 publications

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

Βisphenol A and its analogs migrated from contact materials into food and beverages: An updated review in sample preparation approaches

Bisphenol A Removal by the Fungus Myrothecium roridumIM 6482—Analysis of the Cellular and Subcellular Level

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