Assessment of myocardial function and perfusion in a canine model of non-occlusive coronary artery stenosis using fast magnetic resonance imaging

Schwitter, Juerg; Saeed, Maythem; Wendland, Michael F.; Sakuma, Hajime; Bremerich, Jens; Canet, Emmanuelle; Higgins, Charles B.

doi:10.1002/(sici)1522-2586(199901)9:1<101::aid-jmri14>3.0.co;2-9

Cited by 32 publications

(17 citation statements)

References 45 publications

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“…14,15 Because open-chest surgical access can result in potential artifacts on MRI, we used an interventional closed-chest model for creating an acute nonocclusive coronary stenosis. The distal portion (Ϸ8 cm) of an 8F guiding catheter (Cordis Roden), including the radiographic marker, was cut off to avoid any significant artifacts on MRI.…”

Section: Closed-chest Interventional Model For Coronary Stenosismentioning

confidence: 99%

“…In 1 additional swine, we found a small lesion of late enhancement on the scans acquired 40 and 60 minutes after injection that was suggestive of myocardial infarction, which was confirmed by TTC staining ( Figure 6) and is seen infrequently in closed-chest animal models. 14,15 In addition to redistribution into the formerly ischemic area, necrosis is known to accumulate extracellular contrast agents because of cell damage with resultant higher contrast concentrations. 22 However, in infarction, the amount of assessable collagen may be different and hence may influence the signal with the use of EP-3600.…”

Section: Spuentrup Et Al Molecular Mri Of Myocardial Perfusionmentioning

confidence: 99%

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Molecular Magnetic Resonance Imaging of Myocardial Perfusion With EP-3600, a Collagen-Specific Contrast Agent

et al. 2009

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Background-Cardiac magnetic resonance (MR) perfusion imaging during the first pass after intravenous administration of extracellular contrast agents is hampered by the spatial and temporal resolution achievable and by the artifacts seen in ultrafast MR imaging. Furthermore, time-consuming quantitative data analysis is often added. The use of molecular MR imaging with a target-specific contrast agent with perfusion-dependent binding to myocardium may enable prolonged visualization of perfusion defects and thus may help to overcome limitations of currently used first-pass extracellular MR imaging. EP-3600 is a new gadolinium-containing molecular contrast agent that binds reversibly to myocardial collagen. Methods and Results-A significant but nonocclusive coronary artery stenosis was modeled in 7 domestic swine with an undersized MR-compatible balloon positioned in the left anterior descending artery as verified by x-ray angiography. Two animals died before contrast injection as a result of arrhythmias. In 5 swine, high-spatial-resolution gradient echo imaging (Ϸ1ϫ1 mm 2 in-plane resolution) was performed before and 5, 20, 40, and 60 minutes after intravenous administration of 12.3 mol/kg EP-3600. Contrast was administered during stress induced by an infusion of 250 mol · kg Ϫ1 · min Ϫ1 adenosine. Yb-DTPA was administered simultaneously for comparison of myocardium-to-plasma ratios. Images were assessed subjectively by 2 investigators, and signal-to-noise and contrast-to-noise ratios over time were calculated. Normal myocardium showed a significant signal-to-noise ratio increase during the entire examination time. In all animals (nϭ5), the perfusion defect in the left anterior descending artery territory could be visualized with a high contrast-to-noise ratio for at least 20 minutes after contrast injection. A significantly higher myocardium-to-plasma ratio was found for EP-3600 compared with the control agent Yb-DTPA (0.85Ϯ0.26 versus 0.22Ϯ0.08, respectively; PϽ0.01). Conclusion-EP-3600 is a new molecular MR imaging contrast agent that binds to the myocardium and enables prolonged, high-contrast, high-spatial-resolution visualization of myocardial perfusion defects. (Circulation. 2009;119:1768-1775.)

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Section: Closed-chest Interventional Model For Coronary Stenosismentioning

confidence: 99%

Section: Spuentrup Et Al Molecular Mri Of Myocardial Perfusionmentioning

confidence: 99%

Molecular Magnetic Resonance Imaging of Myocardial Perfusion With EP-3600, a Collagen-Specific Contrast Agent

et al. 2009

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“…This concept has been applied first in animals [6][7][8] and consequently in human beings. 9,10 The magnetic resonance (MR) contrast medium (CM) enters the microvasculature and also starts to diffuse within the interstitial space during the first pass.…”

Section: Principles Of Ischemia and Viability Imaging: Comparison Of mentioning

confidence: 99%

“…In the past an inversion recovery preparation was most often used, 6,8,9,17,[26][27][28] because it provides a large dynamic range of signal response, theoretically from negative to positive longitudinal magnetizations ϪM z to ϩM z . However, in practice the delay time from preparation to readout was selected to obtain near-zero magnetization before the start of readout, which required 300 to 400 milliseconds of waiting time, thus precluding true multislice imaging.…”

Section: Magnetization Preparationmentioning

confidence: 99%

“…Whereas absolute quantification of perfusion is still challenging and not all issues are resolved, the quantification of perfusion-related parameters appears best suited to serve as an interstudy standard. Perfusion-related parameters have been applied widely and are, for example, the upslope of signal during first-pass conditions, 7,10,13,14,17,26,29,33 the maximum signal during the first pass, 6,8,14,54,60 the time to peak, the mean transit time, 7,14,53 the area under the signal intensity-time curve, 61 and many others. Before an analysis algorithm is applied, the perfusion data are typically registered-that is, motion resulting from a drift of the diaphragm or even from breathing is eliminated by shifting the images in the time series, which can be achieved by hand or by means of algorithms.…”

Section: Perfusion Data Analysesmentioning

confidence: 99%

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