Assessment of myocardial perfusion and systolic function in patients with coronary artery disease after coronary artery bypass surgery by myocardial contrast echocardiography and two-dimensional strain echocardiography

Liu, Rong; Deng, Yong; Bi, Xiaojun; Liu, Yani; Xiong, Li; Chen, Liuping

doi:10.1007/s11596-009-0526-1

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Currently, the mechanism behind CSFP has not been fully elucidated. Current literature on CSFP propose abnormal microvascular regulation, [2] endothelial function injury and inflammatory response [3][4][5], oxidative stress and atherosclerosis of coronary artery [6][7][8], mean platelet volume or abnormal platelet function and imbalance of vasoactive substances [9][10][11][12][13] underly CSFP pathology. However, there is a general agreement that CSFP is closely related to inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

Liang

Lin

et al. 2019

Preprint

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Background: Atherosclerosis is a chronic inflammatory disease. The pathology underlying the disease consists of accumulation of the extracellular matrix, lipid and inflammatory cells. Coronary s low f low p henomenon (CSFP) is closely related to inflammatory responses, while chemokines plays an important role in the progression of atherosclerosis. However, the relationship between chemokines and CSFP is still unclear. In this study, our aims were to evaluate the association between CXC Chemokines 9 (CXCL9) levels and CSFP in patients with coronary artery disease. Methods: We studied 46 patients diagnosed with CSFP and classifyed them as the CSFP group. 50 patients with normal coronary angiography (CAG) were randomly selected as the no-CSFP group in our study. The mean TIMI frame count (TFC) was used to measure coronary blood flow velocity. The clinical and biochemical index, including serum levels of IL1, IL-6, IL-10, CXCL9, CD40L and interferon- γ (IFN- γ ), were analyzed in all subjects. Results: The serum levels of IL-1, IL-6, IL-10, CXCL9, CD40L, IFN- γ and CXCL9 in the CSFP group were significantly higher than those in the no-CSFP group, with the differences being statistically significant (p<0.001). Furthermore, Pearson's correlation analysis reflected a significant positive correlation (r=0.171, p=0.01) in CXCL9 levels. Multivariate logistic regression analysis showed that CXCL9 is an important risk factor for CSFP ( β =1.795, P =0.000). Subsequent ROC curve analyses indicated that the serum CXCL9 levels demonstrated a high diagnostic value in differentiating patients with CSFP from that of normal controls (Area Under the Curve = 0.758) and the serum CXCL9 level of 131.915 mg/L was a predictor of CSFP, with a sensitivity of 54 . 3 % and a specificity of 96.0%, respectively. Conclusions: Our findings are indicative of the potential clinical implications of CXCL9 in the occurrence and development of CSFP.

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Section: Introductionmentioning

confidence: 99%

CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

Liang

Lin

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Currently, the mechanism behind CSFP has not been fully elucidated. Current literature on CSFP propose abnormal microvascular regulation, [2] endothelial function injury and inflammatory response [3][4][5] , oxidative stress and atherosclerosis of coronary artery [6][7][8] , mean platelet volume or abnormal platelet function and imbalance of vasoactive substances [9][10][11][12][13] underlying CSFP pathology. However, there is general agreement that CSFP is closely related to inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

Liang

Lin

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Atherosclerosis is a chronic inflammatory disease. The pathology underlying the disease consists of accumulation of the extracellular matrix, lipid and inflammatory cells. Coronary Slow Flow Phenomenon (CSFP) is closely related to inflammatory responses, while chemokines play an important role in the progression of atherosclerosis. However, the relationship between chemokines and CSFP is unclear. In this study, our aims were to evaluate the association between CXC Chemokines 9 (CXCL9) levels and CSFP in patients with coronary artery disease. Methods: We studied 46 patients diagnosed with CSFP and classed them as the CSFP group. 50 patients with normal coronary angiography (CAG) were randomly selected as the no-CSFP group in our study. The mean TIMI frame count was used to measure coronary blood flow velocity. The clinical and biochemical index, including serum levels of IL1, IL-6, IL-10, CXCL9, CD40L and interferon-γ (IFN-γ), were analyzed in all subjects. Results: The serum levels of IL-1, IL-6, IL-10, CXCL9, CD40L, IFN-γ and CXCL9 in the CSFP group were significantly higher than those in the no-CSFP group, with the differences being statistically significant (p<0.001). Furthermore, Pearson's correlation analysis reflected a significant positive correlation (r=0.171, p=0.01) in CXCL9 levels. Multivariate logistic regression analysis showed that CXCL9 are important risk factors for CSFP (β=1.795, P=0.000). Subsequent ROC curve analyses indicated that the serum CXCL9 levels demonstrated a high diagnostic value in differentiating patients with CSFP from that of normal controls (Area Under the Curve = 0.758) and the serum CXCL9 level of 131.915 mg/L was a predictor of CSFP, with a sensitivity of 54.3% and a specificity of 96.0%. Conclusions: Our findings are indicative of the potential clinical implications of CXCL9 in the occurrence and development of CSFP.

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Evaluation of “J”-shaped uterine incision during caesarean section in patients with placenta previa: A retrospective study

Zou

Zhong

Yin

et al. 2010

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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This study evaluated the efficacy and safety of "J"-shaped uterine incision for caesarean section for patients diagnosed with placenta previa. A total of 55 consecutive cases of placenta previa treated in Union Hospital were retrospectively analyzed over a period of two years and 10 months. The subjects were divided into two groups with respect to the uterine incision. Twenty-four pregnant women with placenta previa who were indicated for caesarean section underwent the procedure using a new "J"-shaped uterine incision and 31 pregnant women with placenta previa received caesarean section that used the traditional transverse incision. The two groups were compared in terms of operation time, estimated blood loss, infant expulsion time, exhaust time and postoperative recovery. Meanwhile, comparison was also made in neonatal clinical data between the two groups. Compared with the "J"-shaped incision group, the traditional incision group had a lower Apgar scores (P<0.05). However, there existed no statistically significant differences in the overall time of operation and postoperative period of breaking wind (P>0.05). It is concluded that, with caesarean section for placenta previa patients, the "J"-shaped uterine incision significantly decreases intraoperative blood loss and facilitates the fetal delivery.

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Assessment of myocardial perfusion and systolic function in patients with coronary artery disease after coronary artery bypass surgery by myocardial contrast echocardiography and two-dimensional strain echocardiography

Cited by 4 publications

References 26 publications

CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

Evaluation of “J”-shaped uterine incision during caesarean section in patients with placenta previa: A retrospective study

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