Assessment of nano-hydroxyapatite and poly (lactide-co-glycolide) nanocomposite microspheres fabricated by novel airflow shearing technique for in vivo bone repair

Song, Wenzhi; Wang, Dezhou; Guo, Min; Han, Chenyu; Zhao, Liang; Zhang, Peibiao

doi:10.1016/j.msec.2021.112299

Cited by 20 publications

(9 citation statements)

References 41 publications

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“…PLGA/HA/gelatin and PLGA/HA/collagen scaffolds proved to have enhanced osteogenic proliferation activity [ 140 , 143 , 152 ]. PLGA/HA microspheres showed accelerated bone mineralization activity along with enhanced osteoblast proliferation and differentiation in vivo [ 187 ]. PDA and polyethyleneimine (PEI) were used to chemically immobilize RGD peptides at the surface of PLGA/HA scaffolds [ 123 , 164 ].…”

Section: Plga-loaded Bioactive Molecules For Bone Regenerationmentioning

confidence: 99%

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Hassan,

Abdelnabi,

Mohsin

2024

Pharmaceutics

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Recently, nanotechnologies have become increasingly prominent in the field of bone tissue engineering (BTE), offering substantial potential to advance the field forward. These advancements manifest in two primary ways: the localized application of nanoengineered materials to enhance bone regeneration and their use as nanovehicles for delivering bioactive compounds. Despite significant progress in the development of bone substitutes over the past few decades, it is worth noting that the quest to identify the optimal biomaterial for bone regeneration remains a subject of intense debate. Ever since its initial discovery, poly(lactic-co-glycolic acid) (PLGA) has found widespread use in BTE due to its favorable biocompatibility and customizable biodegradability. This review provides an overview of contemporary advancements in the development of bone regeneration materials using PLGA polymers. The review covers some of the properties of PLGA, with a special focus on modifications of these properties towards bone regeneration. Furthermore, we delve into the techniques for synthesizing PLGA nanoparticles (NPs), the diverse forms in which these NPs can be fabricated, and the bioactive molecules that exhibit therapeutic potential for promoting bone regeneration. Additionally, we addressed some of the current concerns regarding the safety of PLGA NPs and PLGA-based products available on the market. Finally, we briefly discussed some of the current challenges and proposed some strategies to functionally enhance the fabrication of PLGA NPs towards BTE. We envisage that the utilization of PLGA NP holds significant potential as a potent tool in advancing therapies for intractable bone diseases.

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Section: Plga-loaded Bioactive Molecules For Bone Regenerationmentioning

confidence: 99%

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Hassan,

Abdelnabi,

Mohsin

2024

Pharmaceutics

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“… Tissue Materials Degradation Property Synthetic Method Modification Method Cell/Growth Factor/Drug In Vivo Ref. 1 Bone PLGA Biodegradable Airflow shearing Nano HAP for osteogenesis In-situ encapsulation MC3T3-E1 Rat [ 201 ] 2 PLGA Biodegradable High-voltage electrostatic Sr-BTO NPs for restore electric microenvironment In-situ encapsulation MC3T3-E1 Rat [ 202 ] 3 PHBV Non-biodegradable S/O/W emulsion/solvent evaporation Wollastonite for apatite layer forming In-situ encapsulation Gentamicin / [ 203 ] 4 PLLA Biodegradable Vacuum infiltration & Template Method CFO@BTO NPs for piezoelectric property In-situ encapsulation MG63 cells / [ 139 ] 5 PLGA Biodegradable High-voltage electrostatic HAP, AT for conductivity PDA adhesion IGF-1 Rat [ 138 ] 6 PAGTP Biodegradable Emulsification AT for Electrophysiologic...…”

Section: Electroactive Microcarriersmentioning

confidence: 99%

Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier

Zhang,

Ma,

et al. 2024

Bioactive Materials

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“…Silva (2022) et al processed polyvinylidene fluoride (PVDF) and HA composite filaments by twin-screw extrusion with different processing screw fin angular speeds [ 92 ]. Wenzhi (2021) et al prepared microspheres of HANPs and poly (lactide-co-glycolide) nanocomposite for bone repair by a novel airflow shearing technology and evaluated its potential for clinical application as in vivo bone repair fillers [ 93 ]. Mahmoud (2020) et al produced alginate/HANPs composite scaffolds by utilizing fish bones as a biosource for HANPs [ 94 ].…”

Section: Recent Strategies For Compounding Natural and Synthetic Poly...mentioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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Assessment of nano-hydroxyapatite and poly (lactide-co-glycolide) nanocomposite microspheres fabricated by novel airflow shearing technique for in vivo bone repair

Cited by 20 publications

References 41 publications

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

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