Assessment of neurologic outcome in asphyxiated term infants by use of serial CK-BB isoenzyme measurement

Early Biochemical Indicators of Hypoxic-Ischemic Encephalopathy after Birth Asphyxia

“…Concerning CK-BB, these results are in accordance with studies where the increase was within the first 4 -15 h of life (13)(14)(15). Our serum CK-BB activities were lower than in the studies of Walsh et al (14) and Fernandez et al (15), which was probably related to the measurement of total creatine kinase activity at different temperatures.…”

“…Our serum CK-BB activities were lower than in the studies of Walsh et al (14) and Fernandez et al (15), which was probably related to the measurement of total creatine kinase activity at different temperatures. CK-BB is also expressed in placenta, lungs, gastrointestinal tract, and kidneys, all of which might be involved in the sequelae of asphyxia.…”

“…CK-BB is found in both neurons and astrocytes. CK-BB and NSE levels have been found to be elevated after birth asphyxia, but few data exist that concern the early time course of these factors after the hypoxic-ischemic event (13)(14)(15)(16)(17). Serum concentration of protein S-100 after birth asphyxia has not been assessed yet.…”

Glial Fibrillary Acidic Protein in the Cerebrospinal Fluid: A Possible Indicator of Prognosis in Full-Term Asphyxiated Newborn Infants?

“…In one earlier study, GFAP was measured in children with subacute sclerosing panencephalitis or severe brain degenerative disease due to metabolic storage or lysosomal diseases (6) and increased levels were found in some cases. CKBB in serum has been shown to increase within the first 4-15 h of life in infants after perinatal asphyxia (15,33,34). However, the predictive value of CKBB was equal or inferior to that of clinical, neuroradiologic, or neurophysiologic examinations in one study.…”

Cerebral blood flow in a case of fetal brain death syndrome

“…Neonates with hypoxic-ischemic encephalopathy show CK and LDH levels ranging from a few thousand to tens of thousands in blood tests during the first few days after brain injury. The values become normal after about a week 12,13 . The fact that this infant's CK and LDH levels were normal at birth suggests that the brain damage had occurred before the mother noticed the absence of fetal movement.…”