Assessment of Neuropharmacological Profile of Ethanolic Extract of Lawsonia Inermis Flowers

Fathima, Syeda Nishat; Hemalatha, G.; Smitha, T; Rama, M. V.

doi:10.12723/mjs.55.4

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Locomotor activity was measured using an actophotometer, as reported by Nishat Fathima et al (2020) . An actophotometer provided with a digital counter with infrared sensors and a computerized counter and light source was used to measure locomotor activity (horizontal movement) of animals.…”

Section: Methodsmentioning

confidence: 99%

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats

et al. 2022

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Chronic neuropathy is a common and debilitating problem that poses a significant challenge to health care worldwide. Natural compounds have received considerable attention as potential sources of new drugs for the treatment of neuropsychiatric pain. Catechin is a well-known novel flavonoid with several therapeutic properties, notably in neurodegenerative diseases. The current study is designed to investigate the role of catechin in neuroprotective activity in the chronic constriction injury (CCI) model. Apparently, healthy adult male Sprague–Dawley rats weighing 160–190 g (8 weeks old) were selected and grouped into the following: sham (distilled water), CCI group (CCI), standard [CCI + pregabalin (10 mg/kg, p.o.)], and test catechin [CCI + catechin (50 and 100 μg/kg p.o.)] for 28 days. Behavioral, thermal, and mechanical changes were evaluated. The results showed that mechanical allodynia and thermal hyperalgesia were reduced in the catechin-treated group when compared with the CCI group. In addition, the relationship between the analgesic effect of catechin and the expressions of TNF-α, IL-6, and IL-β was established. The results showed that catechin reversed the signs of neuropathic pain. It also decreased the levels of TNF-α, IL-6, and IL-β in the rat brain. Therefore, the results suggested that catechin has promising potential in the treatment and management of neuropathic pain by decreasing the levels of NF-κβ–regulated inflammatory cytokines in the chronic constriction injury model.

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Section: Methodsmentioning

confidence: 99%

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats

et al. 2022

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“…It is also called Egyptian privet, mignonette tree in Jamaica, French Henne, Mehndi in Urdu and Alcana in Spanish. North Africa, Asia, the Middle East, Egypt, America, and Australia are its home continents (Malekzadeh, 1968;Syeda et al, 2020).…”

Section: Taxonomic Classificationmentioning

confidence: 99%

An Up-to-Date Review on the Phytochemical and Pharmacological Aspects of the Lawsonia Inermis

Batool,

Ashiq,

Khalid

et al. 2023

THE JAPS

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Medicinal plants are extensively used throughout the world to treat a variety of ailments because of their safety, efficacy and affordability. Lawsonia inermis or Henna is commonly used in folk medicine for the cure of several illnesses. Particularly, it is used as a hair and hand dye. The objective of this study is to offer the most recent information regarding the pharmacological and phytochemical profile of the medicinal plant that is backed by evidence. Only indexed research and review papers were taken into account for the present study's data gathering in order to ensure authenticity. Only articles published in English language were considered for this study. To conduct a literature survey, various databases such as Scopus, Google Scholar, PubMed, Science Direct, and MEDLINE were searched without any year limit. The following keywords are used to search the data: "Lawsonia inermis", "medicinal plants", "herbs", "phytochemical", "pharmacological", "in vivo", "in vitro", "Henna" and "toxicity". The study's findings showed that the plant contains a variety of potent phytochemicals, including Lawsona, linarigenin, linarisenin, luteolin, lawsochrysin, lawsoniaside, lawsonaphthoate e.tc. The fruits, leaves, and stems of L. inermis have all been demonstrated to have potential pharmacological effects in previous investigations. So far, its antioxidant, cytotoxic, antimicrobial, antiprotozoal, immunomodulatory, hypoglycemic, anti-inflammatory, and anticancer properties have been documented. Even though many aspects of the plant have been researched, additional study is still necessary to completely understand the mechanism behind its pharmacological actions, to confirm its medicinal efficacy, and to justify its usage in traditional medicine.

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“…The root paste is applied on painful edema and hemorrhoids. Seed oil is used for massage in Vāta disorders [7] .…”

Section: Medicinal Properties and Pharmacological Activity According ...mentioning

confidence: 99%

A Review on Pharmacological activities and Medicinal properties of Baliospermum montanum

Samaranayaka Liyanage Gayani Sewwandi,

Rochelle Mangella Peiris

2023

GSC Biol. Pharm. Sci.

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Baliospermum montanum which belongs to Euphorbiaceae family is a commonly used plant in both Ayurveda and traditional medicine system in Sri Lanka. It is also known as the “Detta” in Sinhala and “Danti” in Sanskrit. This review aims to provide an overview on pharmacological activities and medicinal properties of Baliospermum montanum. The information was collected from Ayurveda authentic texts, scientific journals and through electronic media. According to Ayurvedic texts roots, leaves, seed and seed oil of Baliospermum montanum are mostly used. According to Ayurveda pharmacological properties of Baliospermum montanum Katu Rasa, Guru Theekshna Guna, Katu Vipāka, Ushna Veerya, Kapha Pitta Shāmaka action. Prabhāva is the purgation. Other medicinal properties are Ashukāri, Vikāsi, Krimihara, Kushtahara, Kaphahara, Vātahara, Dushta Vrana Shōdhana, Udara, Arshōgna, Ashmarihara, Shoolahara, Deepana, Pāchana, Shōdhana, Sara, Ānahahara, Shōpahara, Vidāhahara, Kanduhara, Pleehāhara, Gulmahara and Krimihara. Baliospermum montanum act as purgative. It induces diarrhea and therapeutically it is useful in constipation, anaemia, leucoderma, skin disease, disorders of digestive system, circulatory system, respiratory system, urinary system and skin. Pharmacological actions are Anti-cancer, Anti-microbial, Anti-fungal, Anti-oxidant, Anti-worm, Anti-diabetic, free radical scavenging, immunomodulatory, hepatoprotective, digestive, diuretic, diaphoretic, rubefacient, febrifuge, tonic, anthelmintic, hypotensive, odontalgic, thermogenic, purgative, anodyne, anti-inflammatory, stimulant, anti-dote for snake bite, anti-rheumatic, anti-asthmatic, wound healing, cathartic and anti-dropsical. The present review attempts to encompass the up to date comprehensive literature analysis on Baliospermum montanum with respect to its pharmacological activities and its medicinal properties.

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Assessment of Neuropharmacological Profile of Ethanolic Extract of Lawsonia Inermis Flowers

Cited by 3 publications

References 15 publications

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats

An Up-to-Date Review on the Phytochemical and Pharmacological Aspects of the Lawsonia Inermis

A Review on Pharmacological activities and Medicinal properties of Baliospermum montanum

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