Assessment of Neutrophil to lymphocyte ratio in patients with diabetic nephropathy

Abstract

To assess neutrophil to lymphocyte ratio in patients with diabetic nephropathy. Materials and Methods: The present study was conducted with the aim of assessing Neutrophils to Lymphocytes ratio (NLR) in patients with Diabetic Nephropathy. A total of 50 type 2 diabetic patients were enrolled and were divided into two study groups as follows: Group A-Diabetic Patients diagnosed with Diabetic Nephropathy, and Group B-Diabetic patients without Diabetic Nephropathy. Baseline demographic and clinical details of all the patients was obtained. Blood samples were obtained and NLR was assessed. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Chi-square test and student t test were used for evaluation of level of significance. Results: Overall NLR among diabetic patients with and without diabetic nephropathy was found to be 2.96 and 1.86 respectively. On comparing statistically, it was seen that mean NLR was significantly raised among diabetic patients with diabetic nephropathy. Conclusion: Inflammation and endothelial dysfunction could be an integral part of DN. NLR was significantly and independently raised in patients with type 2 DM having increased albuminuria.

The Correlation of the Neutrophil-to-Lymphocyte Ratio With Microvascular Complications in Patients With Diabetes Mellitus

“…Another study by Singh et al reported similar results, showing that the NLR could be considered a reliable predictive marker in diabetic nephropathy [ 21 ]. In a study by Khan et al, the NLR of subjects with type 2 diabetes and increased albuminuria was markedly elevated [ 22 ].…”