Assessment of Nonalcoholic Fatty Liver Disease in Rats Using Quantitative Dynamic Contrast‐Enhanced MRI

Wu, Zhuo; Cheng, Zhigang; Yi, Zhilong; Xie, Mingwei; Zeng, Hong; Lu, Liejing; Xu, Xinyun; Shen, Jun

doi:10.1002/jmri.25455

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…OATP1B2 was not examined in that study. Another model of mouse fibrosis induced by NAFLD has also been shown to have altered liver GBCA uptake with DCE-MRI (13,33). NAFLD is highly comorbid with T2D, because steatosis is observed within the liver, which is similar to our findings in ob/ob mice (Fig.…”

Section: Discussionsupporting

confidence: 87%

Dynamic Contrast–Enhanced MRI of OATP Dysfunction in Diabetes

et al. 2018

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Section: Discussionsupporting

confidence: 87%

Dynamic Contrast–Enhanced MRI of OATP Dysfunction in Diabetes

et al. 2018

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“…A few recent trials used DCE MRI in animal models for diffuse liver disease, including one that found increased K trans in hepatic steatosis and fibrosis in NAFLD (52). However, in another study using a rat liver fibrosis model without the effect of steatosis, K trans was negatively correlated with fibrosis stages (53).…”

Section: Clinical Applications Of Quantitative Hepatobiliary Imagingmentioning

confidence: 99%

“…A dual-input single-compartment model was applied, but it could not reflect the relationship between plasma space and EES (51). A few previous studies have also considered a dual-input two-compartment model using software (52,53), but no software considering this model is available at this time from major vendors. Therefore, as an alternative method, a single-input two-compartment model was used in recent investigations by considering that the abdominal aorta could be used as a surrogate input source of the liver (51,54).…”

Section: Dynamic Contrast-enhanced Mrimentioning

confidence: 99%

Quantitative Imaging in Pediatric Hepatobiliary Disease

et al. 2019

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Pediatric hepatobiliary imaging is important for evaluation of not only congenital or structural disease but also metabolic or diffuse parenchymal disease and tumors. A variety of ultrasonography and magnetic resonance imaging (MRI) techniques can be used for these assessments. In ultrasonography, conventional ultrasound imaging as well as vascular imaging, elastography, and contrast-enhanced ultrasonography can be used, while in MRI, fat quantification, T2/T2 * mapping, diffusion-weighted imaging, magnetic resonance elastography, and dynamic contrast-enhanced MRI can be performed. These techniques may be helpful for evaluation of biliary atresia, hepatic fibrosis, nonalcoholic fatty liver disease, sinusoidal obstruction syndrome, and hepatic masses in children. In this review, we discuss each tool in the context of management of hepatobiliary disease in children, and cover various imaging techniques in the context of the relevant physics and their clinical applications for patient care.

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“…IVIM is first established by Le Bihan, 1 which is used as a quantitative parameter of diffusion and perfusion of water molecules. Dynamic contrast‐enhanced MR technique provides us different quantitative parameters about hemodynamic perfusion 3–5 …”

mentioning

confidence: 99%

“…Dynamic contrast-enhanced MR technique provides us different quantitative parameters about hemodynamic perfusion. [3][4][5] Ischemic/reperfusion injury (IRI) of various organs is one of the pathologies related to blood flow that has been attracting attention recently. IRI is defined as the paradoxical exacerbation of cellular dysfunction and death, following restoration of blood flow to previously ischemic tissues.…”

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confidence: 99%