Assessment of occupational exposure to fine particulate matter in dental prosthesis laboratories in Kocaeli, Turkey

Yıldırım, Serap; Pekey, Beyhan; Pekey, Hakan

doi:10.1007/s10661-020-08620-8

Cited by 8 publications

(12 citation statements)

References 55 publications

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“…For example, in dental prosthetic laboratories with manual production, particulate matter is released when abrasion and polishing are performed. Particulate matter has been reported to directly cause lung cancer as well as other respiratory illnesses [20]. The effect of an intervention A aimed at reducing respiratory disease incidence Y by limiting (or mediated by) occupational exposure to particulate matter M could lead to better methods of safe-guarding the lab technicians.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of an intervention A aimed at reducing respiratory disease incidence Y by limiting (or mediated by) occupational exposure to particulate matter M could lead to better methods of safe-guarding the lab technicians. Particulate matter M can be measured using an inductively coupled plasma mass spectrometer (ICP-MS) device that can only measure particulate matter above a limit of detection [20].…”

Section: Discussionmentioning

confidence: 99%

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Causal mediation analysis with mediator values below an assay limit

Chernofsky,

Bosch,

Lok

2021

Preprint

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Causal indirect and direct effects provide an interpretable method for decomposing the total effect of an exposure on an outcome into the effect through a mediator and the effect through all other pathways.When the mediator is a biomarker, values can be subject to an assay lower limit. The mediator is affected by the treatment and is a putative cause of the outcome, so the assay lower limit presents a compounded problem in mediation analysis. We propose three approaches to estimate indirect and direct effects with a mediator subject to an assay limit: 1. extrapolation 2. numerical optimization and integration of the observed likelihood and 3. the Monte Carlo Expectation Maximization (MCEM) algorithm. Since the described methods solely rely on the so-called Mediation Formula, they apply to most approaches to causal mediation analysis: natural, separable, and organic indirect and direct effects. A simulation study compares the estimation approaches to imputing with half the assay limit. Using HIV interruption study data from the AIDS Clinical Trials Group described in [Li et al. 2016, AIDS; Lok & Bosch 2021, Epidemiology], we illustrate our methods by estimating the organic/pure indirect effect of a hypothetical HIV curative treatment on viral suppression mediated by two HIV persistence measures: cell-associated HIV-RNA (N = 124) and single copy plasma HIV-RNA (N = 96).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Causal mediation analysis with mediator values below an assay limit

Chernofsky,

Bosch,

Lok

2021

Preprint

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“…DPL workers may contact many toxic substances, including hazardous metal and metal alloys (Arsal Yıldırım et al, 2020;Hariyani et al, 2015;Kim et al, 2002;Yuksel, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that this particle size can reach the cells by passing through the dermal barrier and the circulatory system (Akkurt, 2014). Base metal alloys used in the dental prostheses are cobalt and zinc-containing chromium, nickel, molybdenum and small amounts of silica, beryllium, boron and carbon (Arsal Yıldırım, B. Pekey, & H. Pekey, 2020;Sinitchi, 2017). While the contact of these metals with the skin during the manufacturing process triggers allergic reactions and systemic diseases in the skin, inhalation of the particulate matter can cause many respiratory system diseases, including pneumoconiosis and lung cancer (Abakay et al, 2013;Gupta, Rani, & Garg, 2017;Hirano et al 2018;Okamoto et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Studies show that long-term treatment of chromium, nickel and cobalt metals has carcinogenic effects on humans (Arsal Yıldırım et al, 2020;Sinitchi, 2017;Yuksel, 2021). Carcinogenic agents including asbestos, cadmium, carbon monoxide and carbon dioxide gases, volatile organic compounds, polycyclic aromatic hydrocarbons, elements (lead, nickel, etc.)…”

Section: Introductionmentioning

confidence: 99%

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Diş Laboratuvarı Teknisyenlerinde IL-1Ra ve IL-4 Geni VNTR Polimorfizmlerinin Analizi: Genotip-Fenotip Çalışması

Yüksel

Yıldırım

2021

İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

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For people working in dental prosthesis laboratories (DPL), metal alloys and methylmethacrylate-based monomers and polymers used in the laboratory can pose occupational risks. These risks can cause occupational health problems and toxic effects on human health. This study purposes of researching the effects of occupational exposure because of dental prosthesis manufacturing operations on variable number tandem repeat (VNTR) polymorphisms in IL-1Ra and IL-4 genes. 29 DPL workers, the experimental group, were given a questionnaire, including the symptoms that might arise due to occupational exposure, and their responses were compared with 30 participants as a control group. Genotype distributions and allele frequencies for IL-1Ra intron 2 (rs2234663) and IL-4 intron 3 (rs79071878) VNTR polymorphisms were analyzed using the PCR technique. Both IL-1Ra intron 2 and IL-4 intron 3 polymorphisms identified from the experimental and control groups were not statistically significantly different (p >.05). However, runny nose, burning throat, dyspnea and dryness and rash on the skin were significantly different when DPL workers were compared with the control group according to logistic regression analysis (p <.05). No statistical difference was found in other phenotypic characters. However, due to the limited sample size, our results need to be confirmed in large-scale studies.

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Causal mediation analysis with mediator values below an assay limit

Chernofsky,

Bosch,

Lok

2024

Statistics in Medicine

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Causal indirect and direct effects provide an interpretable method for decomposing the total effect of an exposure on an outcome into the indirect effect through a mediator and the direct effect through all other pathways. A natural choice for a mediator in a randomized clinical trial is the treatment's targeted biomarker. However, when the mediator is a biomarker, values can be subject to an assay lower limit. The mediator is affected by the treatment and is a putative cause of the outcome, so the assay lower limit presents a compounded problem in mediation analysis. We propose two approaches to estimate indirect and direct effects with a mediator subject to an assay limit: (1) extrapolation and (2) numerical optimization and integration of the observed likelihood. Since these estimation methods solely rely on the so‐called Mediation Formula, they apply to most approaches to causal mediation analysis: natural, separable, and organic indirect, and direct effects. A simulation study compares the two estimation approaches to imputing with half the assay limit. Using HIV interruption study data from the AIDS Clinical Trials Group described in Li et al 2016, AIDS; Lok and Bosch 2021, Epidemiology, we illustrate our methods by estimating the organic/pure indirect effect of a hypothetical HIV curative treatment on viral suppression mediated by two HIV persistence measures: cell‐associated HIV‐RNA and single‐copy plasma HIV‐RNA.

show abstract

Assessment of occupational exposure to fine particulate matter in dental prosthesis laboratories in Kocaeli, Turkey

Cited by 8 publications

References 55 publications

Causal mediation analysis with mediator values below an assay limit

Causal mediation analysis with mediator values below an assay limit

Diş Laboratuvarı Teknisyenlerinde IL-1Ra ve IL-4 Geni VNTR Polimorfizmlerinin Analizi: Genotip-Fenotip Çalışması

Causal mediation analysis with mediator values below an assay limit

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