Assessment of Optic Nerve Sheath Diameter and Its Postoperative Regression among Patients Undergoing Brain Tumor Resection in a Tertiary Care Center

Kalim, Zikrullah; Siddiqui, Obaid Ahmed; Nadeem, Abu; Hasan, Muazzam; Rashid, Hassan

doi:10.1055/s-0042-1744117

Cited by 4 publications

(10 citation statements)

References 13 publications

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“…Previous data of postoperative decrease of ONSD was confirmed in our study 9 . The effects of postoperative adjuvant therapy on the observed continuing decrease after surgery have to be further analyzed.…”

Section: Discussionsupporting

confidence: 69%

“…ONSD has been validated as a surrogate for ICP, shows good correlation with individual ICP dynamics, 4–7 and may correlate with outcome in TBI after hematoma removal 8 . Data on ONSD in glioblastoma are scarce—in a heterogenous group of tumors, a decrease in ONSD was observed postoperatively 9 …”

Section: Introductionmentioning

confidence: 99%

“…8 Data on ONSD in glioblastoma are scarce-in a heterogenous group of tumors, a decrease in ONSD was observed postoperatively. 9 Suspicion of GBM requires timely surgery and concomitant adjuvant care. In the realities of patient care and limited resources, scheduling urgent intracranial surgery with regards to operating room capacity, optional intraoperative monitoring, postoperative intensive care monitoring, and inpatient capacity on the ward may be difficult.…”

mentioning

confidence: 99%

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Retrospective longitudinal assessment of optic nerve sheath diameter in patients with malignant glioma

Feucht,

Kerscher,

Ruff

et al. 2023

Cancer Medicine

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IntroductionGlioblastoma (GBM) is a tumor with rapid growth and a possible relationship to elevated intracranial pressure (ICP). High ICP may not always be associated with clinical signs. A non‐invasive technique for assessment of ICP is measuring the optic nerve sheath diameter (ONSD). Identifying patients who need immediate intervention is of importance in neuro‐oncological care. The goal of this study is to assess the available magnetic resonance imaging (MRI) of patients with GBM with respect to pre‐ and postoperative ONSD.Methods and MaterialsRetrospective data analysis was performed on all patients operated for GBM at a tertiary care center between 2010 and 2020. Two pre and one postoperative MRI had to be available. Clinical data and ONSD at multiple time points were analyzed and correlated, as well as preoperative volumetrics.ResultsSixty‐seven patients met the inclusion criteria. Clinical signs of elevated ICP were seen in 25.4% (n = 17), while significant perifocal edema was present in 67.2% (n = 45) of patients. Clinical signs of preoperatively elevated ICP were associated with significantly elevated ONSD at diagnosis (p < 0.001) as well as preoperative tumor volume (p < 0.001). Significant perifocal edema at the time of diagnosis was associated with elevated ONSD (p = 0.029) and higher tumor volume (p = 0.003). In patients with significant edema, ONSD increased significantly between preoperative MRIs (p = 0.003/005). In patients with clinical signs of raised ICP, ONSD also increased, whereas it was stable in asymptomatic patients (yes: 5.01+/−4.17 to 5.83+/−0.55 mm, p = 0.010, no: 5.17+/−0.46 mm to 5.38+/−0.41 mm, p = 0.81). A significant increase of ONSD from diagnosis to preoperative MRI and a significant decrease until 3 months postoperatively were observed (p < 0.001).ConclusionsONSD might help identify high ICP in patients with GBM. In this first‐of‐its kind study, we observed a significant increase of ONSD preoperatively, likely associated with edema. Postoperatively, ONSD decreased significantly until 3 months after surgery and increased again at 12 months. Further prospective data collection is warranted.

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Retrospective longitudinal assessment of optic nerve sheath diameter in patients with malignant glioma

Feucht,

Kerscher,

Ruff

et al. 2023

Cancer Medicine

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“…study. [ 9 ] There was significant regression at 12 and 24 h compared with preoperative values in the postoperative period. Wang et al .…”

Section: Discussionmentioning

confidence: 95%

“…These results are consistent with these studies. [ 9 , 35 , 37 ] The cutoff values for raised ICP was 4.28 ± 0.28 mm in Kalim et al . study.…”

Section: Discussionmentioning

confidence: 99%

A prospective exploratory study to assess echocardiographic changes in patients with supratentorial tumors – Effect of craniotomy and tumor decompression

Ramakumar

Gupta

Arora

et al. 2023

Surgical Neurology International

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Background: Functional changes in the myocardium secondary to increased intracranial pressure (ICP) are studied sparingly. Direct echocardiographic changes in patients with supratentorial tumors have not been documented. The primary aim was to assess and compare the transthoracic echocardiography changes in patients with supratentorial tumors presenting with and without raised intracranial pressure for neurosurgery. Methods: Patients were divided into two groups based on preoperative radiological and clinical evidence of midline shift of <6 mm without features of raised ICP (Group 1) or greater than 6mm with features of raised ICP (Group 2). Hemodynamic, echocardiographic, and optic nerve sheath diameter (ONSD) parameters were obtained during the preoperative period and 48 h after the surgery. Results: Ninety patients were assessed, 88 were included for analysis. Two were excluded based on a poor echocardiographic window (1) and change in the operative plan (1). Demographic variables were comparable. About 27% of the patients in Group 2 had ejection fraction <55% and 21.2% had diastolic dysfunction in Group 2 in the preoperative period. There was a decrease in the number of patients with a left ventricular (LV) function <55% from 27% before surgery to 19% in the postoperative period in group 2. About 5.8% patients with moderate LV dysfunction in the preoperative period had normal LV function postoperatively. We found a positive correlation between ONSD parameters and radiological findings of raised intracranial pressure. Conclusion: The study demonstrated that in patients with supratentorial tumors with ICP, cardiac dysfunction might be present in the preoperative period.

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Optic nerve sheath ultrasound in short-duration human spaceflight

Shirah,

Lee,

Mason

et al. 2025

Neuroscience Research in Short-Duration Human Spaceflight

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Assessment of Optic Nerve Sheath Diameter and Its Postoperative Regression among Patients Undergoing Brain Tumor Resection in a Tertiary Care Center

Cited by 4 publications

References 13 publications

Retrospective longitudinal assessment of optic nerve sheath diameter in patients with malignant glioma

Retrospective longitudinal assessment of optic nerve sheath diameter in patients with malignant glioma

A prospective exploratory study to assess echocardiographic changes in patients with supratentorial tumors – Effect of craniotomy and tumor decompression

Optic nerve sheath ultrasound in short-duration human spaceflight

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