Assessment of oral mucosal lesions with autofluorescence imaging and reflectance spectroscopy

Lalla, Yastira; Matias, Marie Anne Teresa J.; Farah, Camile S.

doi:10.1016/j.adaj.2016.03.013

Cited by 34 publications

(42 citation statements)

References 37 publications

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“…16,18,27,[32][33][34][35] A handheld device, the VELscope, was proposed for clinicians to noninvasively direct the fluorescence images of oral cavity tissues. 16,33,35,[37][38][39][40][41][42][43][44][45][46][47] Some studies observed the spectra of autofluorescence on different anatomical sites and found some characteristics between different sites. The results indicated that quantitative autofluorescence imaging can provide a noninvasive and objective method for detecting oral neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis

et al. 2017

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Oral cancer is a serious and growing problem in many developing and developed countries. To improve the cancer screening procedure, we developed a portable light-emitting-diode (LED)-induced autofluorescence (LIAF) imager that contains two wavelength LED excitation light sources and multiple filters to capture ex vivo oral tissue autofluorescence images. Compared with conventional means of oral cancer diagnosis, the LIAF imager is a handier, faster, and more highly reliable solution. The compact design with a tiny probe allows clinicians to easily observe autofluorescence images of hidden areas located in concave deep oral cavities. The ex vivo trials conducted in Taiwan present the design and prototype of the portable LIAF imager used for analyzing 31 patients with 221 measurement points. Using the normalized factor of normal tissues under the excitation source with 365 nm of the central wavelength and without the bandpass filter, the results revealed that the sensitivity was larger than 84%, the specificity was not smaller than over 76%, the accuracy was about 80%, and the area under curve of the receiver operating characteristic (ROC) was achieved at about 87%, respectively. The fact shows the LIAF spectroscopy has the possibilities of ex vivo diagnosis and noninvasive examinations for oral cancer.

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Section: Introductionmentioning

confidence: 99%

Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis

et al. 2017

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“…Data were extracted and summarised in Tables and based on primary and secondary outcome measures, respectively. Of the 27 included studies, six demonstrated a low risk of bias across all QUADAS‐2 domains (Bhatia, Matias, & Farah, ; Farah, McIntosh, Georgiou, & McCullough, ; Lalla, Matias, & Farah, ,; Paderni et al, ; Rana, Zapf, Kuehle, Gellrich, & Eckardt, ).…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies reported efficacy on detection of OPMD and/or OSCC, with significant heterogeneity and risk of bias noted across the methodologies used (Awan, Morgan, & Warnakulasuriya, ; Betz et al, ; Bhatia et al, ; Cânjău, Todea, Sinescu, Pricop, & Duma, ; Chiang et al, ; Farah et al, ; Koch, Kaemmerer, Biesterfeld, Kunkel, & Wagner, ; Lalla, Matias, & Farah, ; Marzouki et al, ; Moro et al, ; Onizawa, Saginoya, Furuya, & Yoshida, ; Petruzzi et al, ; Sawan & Mashlah, ; Scheer et al, ; Sweeny et al, ). Only three of 15 studies demonstrated low risk of bias across all QUADAS‐2 domains (Bhatia et al, ; Farah et al, ; Lalla et al, ). Two studies assessed the efficacy of VELscope as an adjunct to COE (Bhatia et al, ; Farah et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…A reduction in specificity values was noted in both studies when VELscope was utilised as an adjunct to COE compared to the use of COE alone, with Farah et al () reporting a combined specificity of 68% compared to 82% and Bhatia et al () reporting a combined specificity of 97.1% compared to 99%. The third, prospective cross‐sectional study deemed to have low risk of bias assessed the efficacy of Identafi's multispectral light (Lalla et al, ). Identafi's white light demonstrated equivalent accuracy to COE conducted under extra‐oral LED white light, while the violet (autofluorescence) light alone demonstrated low sensitivity and specificity values for the detection of OPMD and/or OSCC based on both clinical outcomes (27.5%, 27.5%) and histopathology (12.5%, 85.4%; Lalla et al, ).…”

Section: Resultsmentioning

confidence: 99%

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Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

Tiwari

Kujan

Farah³

2019

Oral Diseases

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Objectives This study aimed to systematically review the efficacy of direct optical fluorescence imaging as an adjunct to comprehensive oral examination in the clinical evaluation, risk assessment and surgical management of oral cancer and potentially malignant disorders. Methods Studies adopting autofluorescence devices, evaluating the efficacy of comprehensive oral examination and optical fluorescence imaging in detection, visualisation or management of oral squamous cell carcinoma or oral potentially malignant disorders, as well as discriminating oral epithelial dysplasia from other mucosal lesions, were included in the literature search across bibliographic databases until October 2018. Results Twenty‐seven studies were found to be eligible for inclusion in qualitative analysis. Of these, only six studies demonstrated a low risk of bias across all domains of the methodological assessment tool (QUADAS‐2). Optical fluorescence imaging demonstrated positive results, with higher sensitivity scores, increased lesion detection and visualisation than comprehensive oral examination alone in the clinical evaluation of oral squamous cell carcinoma and oral potentially malignant disorders. Conclusions This review provides promising evidence for the utilisation of optical fluorescence imaging as an adjunct to comprehensive oral examination in varying clinical settings. It is important that devices utilising optical fluorescence imaging are viewed strictly as clinical adjuncts and not specifically as diagnostic devices.

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“…The comparatively low proportion of true LAF lesions in the present study may be due to exclusion of “Other” lesions, as only OPMDs were considered in the final analysis. Previous studies have demonstrated that a number of benign oral mucosal lesions routinely appear to lose AF with devices such as VELscope ® and Identafi ® , including a vast array of pigmented lesions . Laronde's inclusion of these lesions may explain the high rate of LAF positives, suggesting it is essential to use OFI only when a COE is first performed and with a sound understanding of the various oral pathologies which may exist and their typical fluorescence patterns.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of optical fluorescence imaging in identification and triaging of oral potentially malignant disorders: A study of VELscope in the LESIONS programme

Farah

Dost²,

2019

J Oral Pathology Medicine

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Background Optical fluorescence imaging (OFI) has been shown to enhance the detection of oral potentially malignant disorders (OPMD), by providing additional information about the nature of these lesions, with loss of autofluorescence (LAF) signifying potential underlying oral epithelial dysplasia (OED) or malignancy. This study aims to assess the usefulness of OFI in identification and triaging of OPMDs by primary oral health practitioners, in a community setting. Methodology Participants were recruited from the LESIONS programme in South‐East Queensland, Australia. Participants underwent both conventional oral examination (COE) of mucosal tissues as well as screening with OFI by trained dentists and oral health therapists (OHTs). Lesions were classified as homogeneous, non‐homogeneous, lichenoid or other. The study protocol included blanching of lesions detected with VELscope® (diascopy) and a two‐week review and reassessment of all lesions to reduce false‐positive findings. Analysis of decisions made by dentists and OHTs about lesion identification and triaging was undertaken. Results A total of 360 participants underwent both COE and OFI screening and presented with at least one lesion detected with either method. Lesion size increased and border distinctness and visibility improved with OFI. Of the 170 lesions that underwent two‐week reassessment, 70% resolved or were confirmed as benign. OHTs were more likely to request review and referral for OPMDs compared to dentists. Conclusion Optical fluorescence imaging is a useful tool to help dentists and OHTs identify and triage patients with possible OPMD in the primary care setting.

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Assessment of oral mucosal lesions with autofluorescence imaging and reflectance spectroscopy

Cited by 34 publications

References 37 publications

Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis

Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis

Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review

Usefulness of optical fluorescence imaging in identification and triaging of oral potentially malignant disorders: A study of VELscope in the LESIONS programme

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