Assessment of orbital hemodynamic changes in primary open angle glaucoma by color Doppler imaging

Noureldine, A.M.; Khaled Mohamed, S.M.; Abdel Fatah Mostafa, H.A.; El Bohy, A.E.

doi:10.1016/j.jfo.2023.03.018

Journal Français d'Ophtalmologie

2023

DOI: 10.1016/j.jfo.2023.03.018

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Assessment of orbital hemodynamic changes in primary open angle glaucoma by color Doppler imaging

A.M. Noureldine,

S.M. Khaled Mohamed,

H.A. Abdel Fatah Mostafa

et al.

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2024

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Cited by 1 publication

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Having Sexual Partners Lowers the Risk of Glaucoma-A Mendelian Randomization Study

Zhuang,

Zhang

2024

Preprint

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Objectives: Previous paper suggested that engaging in sexual activity exacerbated glaucoma symptoms. However, we challenge this viewpoint and designed this Mendelian randomization(MR) study to uncover the truth. Methods: To investigate the causal relationship between the two, this experiment utilized single nucleotide polymorphism(SNPs) related to "lifetime number of sexual partners" (LNSP) from the United Kingdom Biobank (UKB) and SNPs associated with glaucoma from the FinnGen Database. There were a total of 63 SNPs highly correlated with LNSP at the genome-wide significant level, which were merged with glaucoma-related SNPs. After removing their palindromic sequences, MR was conducted using the TwoSample-MR R package. Additionally, tests for heterogeneity and pleiotropy were performed using R programming. Results: In the glaucoma group, MR analysis showed: inverse variance weighted(IVW)(OR=0.758, P=0.030), MR Egger(OR=0.654,P=0.475), simple mode (OR=0.854,P=0.657), weighted median (OR=0.819, P=0.221) and weighted mode(OR=0.803,P=0.501). In the primary open angle glaucoma (POAG) group, the result showed: IVW(OR=0.897,P=0.570), MR Egger(OR=0.425, P=0.335), simple mode(OR=1.659, P=0.412), weighted median(OR=1.052, P=0.855) and weighted mode(OR=1.464,P=0.533). Heterogeneity and pleiotropy were not detected in either group. The funnel plots for both groups were relatively symmetrical. Conclusion: We reveal the truth that having sexual partners not only does not increase the overall incidence of glaucoma but, conversely, also lowers its incidence. Therefore, glaucoma patients should pursue a fulfilling sexual life with your partners with peace of mind.

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Having Sexual Partners Lowers the Risk of Glaucoma-A Mendelian Randomization Study

Zhuang,

Zhang

2024

Preprint

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Assessment of orbital hemodynamic changes in primary open angle glaucoma by color Doppler imaging

Cited by 1 publication

References 14 publications

Having Sexual Partners Lowers the Risk of Glaucoma-A Mendelian Randomization Study

Having Sexual Partners Lowers the Risk of Glaucoma-A Mendelian Randomization Study

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