Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan

Abstract

IMPORTANCE Single endoscopic examination often misses early gastric cancer (GC), even when both high-definition white light imaging and narrow-band imaging are used. It is unknown whether new GC can be detected approximately 1 year after intensive index endoscopic examination. OBJECTIVE To examine whether new GC can be detected approximately 1 year after intensive index endoscopic examination using both white light and narrow-band imaging. DESIGN, SETTING, AND PARTICIPANTSThis case-control study was a preplanned secondary analysis of a randomized clinical trial involving 4523 patients with a high risk of GC who were enrolled

Editorial: PPIs and gastric cancer – Are we dealing with a carcinogen? Authors' reply

“…Consistently, we excluded gastric cancers diagnosed within 1 year of the index date from the analysis to account for the likelihood of synchronous lesions. We agree that a considerable proportion of gastric neoplasms may be missed during endoscopic examination 3–5 . Indeed, out of 22,788 patients, 3912 developed gastric neoplasms within 1 year of the index date and were therefore excluded.…”

Quality indicators in the endoscopic detection of gastric cancer

“…NBI did have a better positive predictive value in diagnosing cancer. Furthermore, a one‐year follow‐up of this high‐risk cohort demonstrated that intensive index endoscopy, with both white light and second‐generation NBI, was not associated with a reduction in the rates of detections of new GC 70 . Hence the limitations of both modalities highlight an unmet need in detecting early cancers.…”

“…Furthermore, a one‐year follow‐up of this high‐risk cohort demonstrated that intensive index endoscopy, with both white light and second‐generation NBI, was not associated with a reduction in the rates of detections of new GC. 70 Hence the limitations of both modalities highlight an unmet need in detecting early cancers. The application of IEE also involves a learning curve though this may be negotiated with training.…”

Validity of low-magnification narrow-band imaging in annual endoscopy screening for gastric neoplasms: A case-control study

“…LM-NBI began on the rst day of March 2019, and 1 month was set as the incubation period. The clinical medical records of the patients were reviewed, and patients who underwent conventional endoscopy (CE) within a year (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) Patients who visited Nagashima Clinic for check-ups or routine follow-ups for chronic gastritis were included. Patient demographics and clinical characteristics were obtained from medical records.…”

“…I empirically set the surveillance period to 1 year because annual and biennial screening is prevalent in Asia 2 . Neoplasias were constantly identi ed during annual observation, and a recent report emphasized the e cacy of 1-year surveillance using WLI and NBI 14 . This annual interval seems appropriate for screening patients with chronic gastritis.…”