Assessment of ovarian reserve in patients with type 1 diabetes: a systematic review and meta-analysis

Yang, Wenjia; Lin, Chu; Zhang, Mengqian; Lv, Fang; Zhu, Xiaoxi; Han, Xueyao; Cai, Xiaoling; Ji, Linong

doi:10.1007/s12020-022-03091-y

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…In a meta-analysis of studies in women with T1DM focusing on ovarian reserve, diminished FSH concentration also has been noticed but without correlations with AMH. However, the authors showed that oestradiol level was negatively correlated with daily insulin doses and HbA1c 12 . It is known that gonadotrophins have impact on AMH production.…”

Section: Discussionmentioning

confidence: 97%

“…It inhibits the recruitment of primordial follicles and reduces the sensitivity of antral follicles to FSH, separating the FSH-independent and FSH-dependent phases of folliculogenesis 21 . Generally, there is evidence for decreased AMH levels in women with T1DM when compared to healthy controls, presented in a recently published meta-analysis 12 . On the other side, discussion on PCOS and increased AMH levels among women with PCOS and T1DM continues 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Anti-Müllerian hormone (AMH) is a hormone produced by granulosa cells of early developing follicles and is related to number of primordial follicles, thus is a suitable biomarker for predicting ovarian function in premenopausal women 11 . A recently published meta-analysis underlined that women with T1DM might be in a risk group for decreased AMH level 12 . Supporting this in an earlier large study, lower antral follicle count and AMH level in T1DM women in comparison to healthy controls have been reported 13 .…”

Section: Introductionmentioning

confidence: 99%

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The association of thyroid autoimmunity with ovarian reserve in women with type 1 diabetes with and without polycystic ovary syndrome

Łebkowska,

Krentowska,

Adamska

et al. 2024

Sci Rep

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The aim of the study was to investigate the relation between thyroid autoimmunity (TAI), reflected as the presence of thyroid peroxidase antibodies (TPOAb), and parameters of ovarian reserve in women with type 1 diabetes (T1DM) and polycystic ovary syndrome (PCOS). We studied 83 euthyroid women with T1DM (age – 26 ± 5 years, BMI – 24 ± 3 kg/m2) – 12 with PCOS and positive TPOAb (PCOS + TPOAb), 29 with PCOS with negative TPOAb (PCOS + noTPOAb), 18 without PCOS with positive TPOAb (noPCOS + TPOAb), 24 without PCOS with negative TPOAb (noPCOS + noTPOAb). Serum concentrations of anti-Müllerian hormone (AMH), sex hormones, TSH, thyroid hormones and TPOAb were assessed. The prevalence of TAI was comparable between PCOS and noPCOS. We did not observe differences in hormonal profile or AMH concentration between two PCOS groups—PCOS + TPOAb and PCOS + noTPOAb (p > 0.05). Women with PCOS + TPOAb had lower FSH concentration and higher LH/FSH index than noPCOS + noTPOAb (p = 0.027; p = 0.019, respectively). Moreover, PCOS + TPOAb had lower oestradiol level than noPCOS + TPOAb (p = 0.041). AMH concentration was higher in both groups with PCOS, independent of TPOAb presence, than in noPCOS + noTPOAb (both p < 0.001). The presence of positive TPOAb titre was not related to the studied parameters of ovarian reserve – AMH and ovarian follicle number. In multiple linear regression analysis, the only significant predictor of AMH in the whole studied group with T1DM was total daily insulin dose U/kg (β = − 0.264; p = 0.022). The presence of TAI did not affect the hormonal profile or ovarian reserve in women with T1DM with and without PCOS.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association of thyroid autoimmunity with ovarian reserve in women with type 1 diabetes with and without polycystic ovary syndrome

Łebkowska,

Krentowska,

Adamska

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Anti-Müllerian Hormone (AMH), a glycoprotein produced exclusively by granulosa cells of ovary ( 25 , 26 ), is the most clinically useful marker of ovarian reserve ( 27 ) because of its strong correlation with primordial follicle pool and aging of ovary ( 28 ). An experimental study in a rat model revealed that AMH levels in the healthy control group were significantly higher than in the non-treated diabetic group ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

Adverse effects of type 2 diabetes mellitus on ovarian reserve and pregnancy outcomes during the assisted reproductive technology process

Qin,

Du,

et al. 2023

Front. Endocrinol.

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ObjectiveTo study the effect of type 2 diabetes mellitus(T2DM)on overall ovarian reserve and pregnancy outcomes during assisted reproductive technology (ART) among childbearing infertile women.DesignRetrospective cohort study.SettingThe Reproductive Medicine Special Hospital, The First Hospital of Lanzhou University, between January 2019 and December 2022.Patient(s)A total of 265 infertile female patients aged 20–45 years who underwent in vitro fertilization-embryo transfer (IVF-ET), intracytoplasmic sperm injection-embryo transfer (ICSI-ET), or rescue intracytoplasmic sperm injection-embryo transfer (RICSI-ET) in the first fresh cycle.Intervention(s)None.Main Outcome Measure(s)Serum Anti-Müllerian Hormone (AMH) levels, clinical pregnancy rate (CPR), live birth rate (LBR), and abortion rate (AR) in the T2DM group and non-T2DM group.Result(s)Patients with T2DM showed statistically decreased levels of AMH compared to the non-T2DM group. During ovarian stimulation, those with T2DM required significantly higher total and initial doses of gonadotropin (GN), although they had fewer retrieved oocytes and worse pregnancy outcomes than the non-T2DM group. Multivariate logistic regression analysis adjusting for confounding factors showed that T2DM alone was an independent risk factor for CPR and LBR (adjusted odds ratio [a OR], 0.458, adjusted 95% confidence interval [CI], 0.235-0.891, P = 0.022; a OR, 0.227, 95% CI, 0.101-0.513, P<0.001; respectively), and the abortion rate in the T2DM group was 3.316 times higher than the non-T2DM group(a OR, 3.316, 95%CI, 1.248-8.811, P = 0.016);ConclusionInfertile patients with T2DM have decreased ovarian reserve, and T2DM has a deleterious impact on clinical pregnancy outcomes during the ART process compared with non-T2DM infertile women.CapsuleInfertile women with T2DM have decreased ovarian reserve and pregnancy outcomes during the assisted reproductive technology process compared with non-T2DM infertile women.

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Assessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis

Luo,

Wang,

Liu

2024

Arch Gynecol Obstet

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Assessment of ovarian reserve in patients with type 1 diabetes: a systematic review and meta-analysis

Cited by 8 publications

References 44 publications

The association of thyroid autoimmunity with ovarian reserve in women with type 1 diabetes with and without polycystic ovary syndrome

The association of thyroid autoimmunity with ovarian reserve in women with type 1 diabetes with and without polycystic ovary syndrome

Adverse effects of type 2 diabetes mellitus on ovarian reserve and pregnancy outcomes during the assisted reproductive technology process

Assessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis

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