Assessment of Oxytetracycline Residue in Cooked and Raw Meat of Chicken Broilers Before and After the End of Official Withdrawal Period

Ziani, Kaddour; Pérez-López, Marcos; Mansouri, Abdeldjallil; Khaled, Meghit Boumédiène; Rodríguez, Antonio Silva; Slimani, Miloud

doi:10.1007/s12161-018-1230-1

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Considering tetracyclines and sulfonamides, all authors agree that these compounds are unstable molecules. However, while some of them indicated that heat treatments are effective in degrading tetracycline and sulfonamide residues to a safe level [157,159,160], others observed that cooking does not guarantee the full breakdown of these compounds [161][162][163][164][165]. Regarding quinolones, although some authors argued that enrofloxacin was an unstable molecule [166], most researchers agreed that it was stable after different cooking methods [167,168].…”

Section: Impact Of Cooking On the Drug Residue Levelsmentioning

confidence: 99%

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Cantón

Lanusse

Moreno

2021

Animals

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Drugs are used in veterinary medicine to prevent or treat animal diseases. When rationally administered to livestock following Good Veterinary Practices (GVP), they greatly contribute to improving the production of food of animal origin. Since humans can be exposed chronically to veterinary drugs through the diet, residues in food are evaluated for effects following chronic exposures. Parameters such as an acceptable daily intake (ADI), the no-observed-adverse-effect level (NOAEL), maximum residue limits (MRLs), and the withdrawal periods (WPs) are determined for each drug used in livestock. Drug residues in food exceeding the MRLs usually appear when failing the GVP application. Different factors related either to the treated animal or to the type of drug administration, and even the type of cooking can affect the level of residues in edible tissues. Residues above the MRLs can have a diverse negative impact, mainly on the consumer’s health, and favor antimicrobial resistance (AMR). Drug residue monitoring programmes are crucial to ensure that prohibited or authorized substances do not exceed MRLs. This comprehensive review article addresses different aspects of drug residues in edible tissues produced as food for human consumption and provides relevant information contributing to rational pharmacotherapy in food-producing animals.

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