Assessment of Pain in Osteoarthritis of the Knee

Thirumaran, Aricia Jieqi; Deveza, Leticia A; Atukorala, Inoshi; Hunter, David J.

doi:10.3390/jpm13071139

Cited by 13 publications

(2 citation statements)

References 110 publications

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“…In addition, there is no global standard for the assessment of any osteoarthritis cognitive factor at present and how to mitigate or avert these [70]. Surgery alone, while largely beneficial, may fail to achieve the desired result as well [71,72].…”

Section: Future Researchmentioning

confidence: 99%

Osteoarthritis and Depression Update: 2023-Can the Stress and Coping Model Help?

Marks

2023

JARH

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Background Osteoarthritis and depression are both key barriers to healthy aging and greatly heighten the risk for many negative health issues that seriously impact life quality. When combined what are the implications? Aim This mini review examines 2023 data pertaining to osteoarthritis and depression and older adults and a possible theoretical framework of stress that may direct our approaches in the future. Methods and procedures Articles published between January 1 and August 15 2023 that addressed the current topic of interest and that were extracted from PUBMED, PubMed Central, Science Direct, and Google Scholar were carefully read and their key points arepresented in narrative form. Results As in the past, very few tangible theory-based prospective analyses that employ valid measures of depression and examine any association of any form of osteoarthritis longitudinally and in a consistent manner prevail. Several reports use the same or similar large cohort to draw upon, and find various degrees of clinical implications, but this may not embrace the need for more inclusivity, sampling strategies, control and diversity issues, as well as embracing the role of cognitions positive and negative. Conclusion Without efforts to develop sound research designs of diverse and carefully differentiated osteoarthritis substantive samples it is impossible to delineate the origin or implications of the osteoarthritis-depression linkage reported currently or arrive at a deep understanding of its relevance, to life quality and public health costs. What is needed to protect against or minimize either or both these clinically related disabling correlates in the aged population warrants timely study.

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Section: Future Researchmentioning

confidence: 99%

Osteoarthritis and Depression Update: 2023-Can the Stress and Coping Model Help?

Marks

2023

JARH

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“…However, the OA pain can be influenced by physiological, psychological (such as depression and catastrophizing), and demographic factors (like age, sex, and comorbidities), leading to significant variation in individuals' pain experience (Fig. 2 ) [ 7 ]. Furthermore, there is significant variability in the pain trajectory, as some individuals experience progression while others remain stable over several years [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives

Sethi,

Anand,

Della Pasqua

2024

Pain Ther

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The multifaceted nature of osteoarthritis (OA) pain presents a challenge in understanding and managing the condition. The diverse pain experiences, progression rates, individual responses to treatments, and complex disease mechanisms contribute to heterogeneity in the clinical studies outcomes. The lack of a standardized methodology for assessing and classifying OA pain challenges healthcare practitioners. This complicates the establishment of universally applicable protocols or standardized guidelines for treatment. This article explores the heterogeneity observed in clinical studies evaluating OA pain treatments, highlighting the necessity for refined methodologies, personalized patient categorization, and consistent outcome measures. It discusses the role of the multidimensional nature of OA pain, underlying pain mechanisms, and other contributing factors to the heterogeneity in outcome measures. Addressing these variations is crucial to establishing a more consistent framework for evidence-based treatments and advancing care of the patient with OA pain.

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Matrix Viscoelasticity Tunes the Mechanobiological Behavior of Chondrocytes

Lan,

Liu,

Liu

et al. 2024

Cell Biochemistry & Function

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In articular cartilage, the pericellular matrix acting as a specialized mechanical microenvironment modulates environmental signals to chondrocytes through mechanotransduction. Matrix viscoelastic alterations during cartilage development and osteoarthritis (OA) degeneration play an important role in regulating chondrocyte fate and cartilage matrix homeostasis. In recent years, scientists are gradually realizing the importance of matrix viscoelasticity in regulating chondrocyte function and phenotype. Notably, this is an emerging field, and this review summarizes the existing literatures to the best of our knowledge. This review provides an overview of the viscoelastic properties of hydrogels and the role of matrix viscoelasticity in directing chondrocyte behavior. In this review, we elaborated the mechanotransuction mechanisms by which cells sense and respond to the viscoelastic environment and also discussed the underlying signaling pathways. Moreover, emerging insights into the role of matrix viscoelasticity in regulating chondrocyte function and cartilage formation shed light into designing cell‐instructive biomaterial. We also describe the potential use of viscoelastic biomaterials in cartilage tissue engineering and regenerative medicine. Future perspectives on mechanobiological comprehension of the viscoelastic behaviors involved in tissue homeostasis, cellular responses, and biomaterial design are highlighted. Finally, this review also highlights recent strategies utilizing viscoelastic hydrogels for designing cartilage‐on‐a‐chip.

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Assessment of Pain in Osteoarthritis of the Knee

Cited by 13 publications

References 110 publications

Osteoarthritis and Depression Update: 2023-Can the Stress and Coping Model Help?

Osteoarthritis and Depression Update: 2023-Can the Stress and Coping Model Help?

Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives

Matrix Viscoelasticity Tunes the Mechanobiological Behavior of Chondrocytes

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