Assessment of parasympathetic control of heart rate by a noninvasive method

Fouad, Fetnat M.; Tarazi, Robert C.; Ferrario, Carlos M.; Fighaly, S.; Alicandri, C

doi:10.1152/ajpheart.1984.246.6.h838

Cited by 167 publications

(148 citation statements)

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“…These variations are largely attributable to respiratory modulation of the outflow of the vagal nerve: the larger the respiratory sinus arrhythmia, the stronger the vagal control of heart rate. 11 Respiratory sinus arrhythmia was measured as described previously. 16,17 Respiratory sinus arrhythmia reactivity was calculated by subtracting the respiratory sinus arrhythmia during the stress tasks from the respiratory sinus arrhythmia at rest.…”

Section: Measurementsmentioning

confidence: 99%

Low Birth Weight Is Associated With Increased Sympathetic Activity

et al. 2003

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Background-Low birth weight may be associated with high blood pressure in later life through genetic factors, an association that may be explained by alterations in sympathetic and parasympathetic activity. We examined the association of birth weight with cardiac pre-ejection period and respiratory sinus arrhythmia (indicators of cardiac sympathetic and parasympathetic activity, respectively) and with blood pressure in 53 dizygotic and 61 monozygotic adolescent twin pairs. Methods and Results-Birth weight of the twins was obtained from the mothers. Pre-ejection period and respiratory sinus arrhythmia were measured with electrocardiography and impedance cardiography at rest, during a reaction time task, and during a mental arithmetic task. In the overall sample, lower birth weight was significantly associated with shorter pre-ejection period at rest, during the reaction time task, and during the mental arithmetic task (Pϭ0.0001, PϽ0.0001, and Pϭ0.0001, respectively) and with larger pre-ejection period reactivity to the stress tasks (Pϭ0.02 and Pϭ0.06, respectively). In within-pair analyses, differences in birth weight were associated with differences in pre-ejection period at rest and during both stress tasks in dizygotic twin pairs (Pϭ0.01, Pϭ0.06, and Pϭ0.2, respectively) but not in monozygotic twin pairs (Pϭ0.9, Pϭ1.0, and Pϭ0.5, respectively). Shorter pre-ejection period explained approximately 63% to 84% of the birth weight and blood pressure relation. Conclusions-Low birth weight is associated with increased sympathetic activity, and this explains a large part of the association between birth weight and blood pressure. In addition, our findings suggest that the association between birth weight and sympathetic activity depends on genetic factors. (Circulation. 2003;108:566-571.)

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Section: Measurementsmentioning

confidence: 99%

Low Birth Weight Is Associated With Increased Sympathetic Activity

et al. 2003

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“…22 The HF component is equivalent to respiratory sinus arrhythmia and is thought to reflect vagal control of heart rate. 23 The TP, LF, or variance are components mediated by both sympathetic and vagal efferent activity. 24 The ratio of LF to HF (LF/HF) and LF in normalized units (LF%) are thought by some investigators to mirror sympathovagal balance or reflect sympathetic modulation, the HF in normalized units (HF%) responses to sympathetic inhibition.…”

Section: Introductionmentioning

confidence: 99%

The Subjective Sleep Quality and Heart Rate Variability in Hemodialysis Patients

Wei

Chung

et al. 2011

Renal Failure

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Introduction: Sleep disturbances and cardiovascular autonomic dysfunction are major complications of hemodialysis (HD). The goal of this study is to identify clinical, heart rate variability (HRV) or laboratory parameters that are independently associated with subjective sleep quality. Patient and methods: Forty-six stable HD patients filled out sleep questionnaires -Pittsburgh sleep quality index (PSQI), Athens insomnia scale (AIS), and Epworth sleepiness scale (ESS). In addition, they received analyses of 5-minute HRV twice, in lying posture before and after HD. We also recruited 50 healthy subjects who received 5-min HRV. Results: The patients with end-stage renal disease have a high rate of poor sleep quality according to PSQI, AIS, and ESS. The activities of total power (0-0.5 Hz), high-frequency power (HF, 0.15-0.40 Hz), low-frequency power (0.04-0.15 Hz), and very-low-frequency power (0.003-0.04 Hz) in HD patients are obviously lower than that in the healthy people. The poor sleepers (PSQI > 5) show lower heart rate, higher HF and variance before HD, but did not show a significant difference after HD. There is no significant difference between HRV and global score of AIS, but the insomnia group (AIS > 5) has higher BMI. These patients with sleepiness (ESS > 9) only reveal lower hemoglobin, although the global score of ESS reveals no significant relationship with HRV. Conclusion: HD patients have a high rate of poor sleep quality and autonomic dysfunction. Greater attention for the evaluation of sleep quality is needed for the better care of HD patients.

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confidence: 99%

“…The software also computed frequency-domain variables using a fastFourier transformation over the 24-hour period, including very-low-frequency power (0.0033 to 0.04 Hz), low-frequency power (0.04 to 0.15 Hz), high-frequency power (0.15 to 0.4 Hz), and wideband frequency power (0.0033 to 0.4 Hz) in square milliseconds. 12,16,17 Very-lowfrequency power and wideband frequency power were available for only 478 participants because the software was upgraded during the study. In a quality control check, we performed blinded repeat measurements of 20 tapes and found >99% concordance in readings between the 2 software programs.…”

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confidence: 99%

“…8,9,19 Low-frequency power is believed to reflect the modulation of sympathetic and parasympathetic tones, 16 whereas high-frequency power is believed to reflect pure parasympathetic tone. 17 Although the precise physiologic meaning of very-low-frequency power is not completely understood, it has been suggested that very-lowfrequency power is influenced by thermoregulation, fluctuation in the renin-angiotensin axis, function of peripheral chemoreceptors, and physical activity, 9 all of which may be associated with adverse cardiovascular outcomes. Proportion of participants who had HRV in the lowest quartile according to presence (hemoglobin ≤ 12 g/dl, n = 90) (dark gray bars) and absence (n = 784) (light gray bars) of anemia.…”

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confidence: 99%

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Relation of Anemia to Low Heart Rate Variability in Patients With Coronary Heart Disease (from the Heart and Soul Study)

Gehi¹,

Ix²,

Shlipak³

et al. 2005

The American Journal of Cardiology

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We examined the association between anemia (hemoglobin ≤12 g/dl) and 6 indexes of heart rate variability (HRV) as measured by 24-hour ambulatory electrocardiography in a cross-sectional study of 874 outpatients who had stable coronary heart disease. Of 90 participants who had anemia, 29% to 41% had low HRV, defined as the lowest quartile of each HRV index, compared with 23% to 25% of the 784 participants who did not have anemia (comparison p values <0.05 for all HRV indexes except high-frequency power). With the exception of high-frequency power, each 1 g/dl decrease in hemoglobin was associated with increased odds of having low HRV. This association remained strong after adjustment for potential confounding variables, including ischemia, left ventricular mass, left ventricular ejection fraction, and diastolic dysfunction. Thus, anemia is associated with low HRV in ambulatory patients who have stable coronary heart disease. Low HRV could potentially mediate the association of anemia with increased cardiac risk.Several small studies have associated anemia due to vitamin B12 deficiency, 1,2 thalassemia, 3 and sickle cell anemia 4 with low heart rate variability (HRV). However, no study has examined whether anemia is associated with HRV in patients who have heart disease. Several studies have shown that low HRV independently predicts sudden cardiac death and overall mortality in patients who have heart disease, [5][6][7][8][9][10] suggesting that low HRV may contribute to the adverse cardiac outcomes associated with anemia. We hypothesized that anemia is associated with an imbalance of cardiac autonomic tone as measured by low HRV in patients who have coronary heart disease (CHD). To determine whether anemia is associated with HRV, we measured hemoglobin and HRV in a cross-sectional study of 874 ambulatory patients who had stable CHD.The Heart and Soul Study is a prospective cohort study of psychosocial factors and health outcomes in patients who have CHD. Details regarding our methods have been previously published. 11 Outpatients who had documented CHD were recruited from 2 veterans affairs medical centers (San Francisco VA Medical Center, San Francisco, California, and the VA Palo Alto Health Care System, Palo Alto, California), 1 university medical center (University of California, San Francisco, California), and 9 public health clinics in the Community Health Network of San Francisco. Patients were eligible to participate if they had ≥1 of the following: a history of myocardial infarction, angiographic evidence of ≥50% stenosis in ≥1 coronary vessel, previous evidence of exercise-induced ischemia by treadmill or nuclear testing, a history of coronary revascularization, or a diagnosis of CHD by an internist or cardiologist (based on NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript a positive angiographic or exercise treadmill test result in >98% of cases). Patients were excluded if they were unable to walk 1 block or were planning to move from the local area within 3 years.Betw...

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Assessment of parasympathetic control of heart rate by a noninvasive method

Cited by 167 publications

References 0 publications

Low Birth Weight Is Associated With Increased Sympathetic Activity

Low Birth Weight Is Associated With Increased Sympathetic Activity

The Subjective Sleep Quality and Heart Rate Variability in Hemodialysis Patients

Relation of Anemia to Low Heart Rate Variability in Patients With Coronary Heart Disease (from the Heart and Soul Study)

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