Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV

Azatyan, Vahe; Yessayan, Lazar; Khachatryan, Anna; Perikhanyan, Anush; Hovhannisyan, Alvard; Shmavonyan, Melanya; Ghazinyan, Hasmik; Gish, Robert G.; Melik-Andreasyan, Gayane; Porksheyan, Kristina

doi:10.3855/jidc.15062

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Ninety-one percent (91%) of the respondents had received oral health training (►Fig. 1). The majority (89.1%) of the respondents had average/above average score in their oral health knowledge assessment (►Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…The mouth is the gateway, window, and mirror of the human body. 1 Healthy practices, such as good oral hygiene measures, regular dental check-ups, and healthy diets play a very crucial role in good oral health maintenance. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Oral hygiene measures such as daily tooth brushing, interdental cleaning, and tongue scraping help to remove oral plaque, pathogenic microbial load, and halitosis, and massage the salivary glands and gingivae.…”

Section: Introductionmentioning

confidence: 99%

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Knowledge and Practices Regarding Oral Hygiene, Cariogenic Diet Intake, and Dental Check-Ups Among Registered Nurses in Nigeria: A Pilot Study

Kanmodi

Amoo

Nwafor

et al. 2023

Journal of Health and Allied Sciences NU

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Objectives To investigate the knowledge and practices of registered nurses in Nigeria concerning oral hygiene, cariogenic diets, and dental check-ups through a pilot study. Methods This study was an online survey of 129 registered nurses in Nigeria. Data were collected via the WhatsApp social media using an electronic questionnaire (Google form). Data analysis was done using the SPSS version 26 software (IBM Corp, New York, USA). Results The response and completeness rates of this pilot study were 41.7% (129/311) and 96.9% 9125/129), respectively. The majority (62.2%) of the respondents were females. The majority (89.1%) had average/above average score on basic oral health knowledge; however, there was no significant relationship between their level of basic oral health knowledge and their sociodemographic characteristics (p > 0.05). The majority (66.7%) of the respondents brushed twice daily, 86.8% used a fluoridated toothpaste, and 60.5% changed their toothbrush every 3 months. Furthermore, more than half (55.8%) consumed sugary snack/drink on daily basis, while 55.0% rinsed their mouth with water immediately after taking sugary snack, and only 55.8% did floss their teeth. Among those who flossed their teeth, only 37.5% did it once daily. It is also striking that 26.4% of the respondents had never visited a dentist for a dental check-up. Conclusion Study findings showed a high level of basic oral health knowledge and a lower level of appropriate oral self-care practices among nurses in Nigeria. However, there is a need for a nationally representative study of nurses in Nigeria to further establish these findings.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Knowledge and Practices Regarding Oral Hygiene, Cariogenic Diet Intake, and Dental Check-Ups Among Registered Nurses in Nigeria: A Pilot Study

Kanmodi

Amoo

Nwafor

et al. 2023

Journal of Health and Allied Sciences NU

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“…On the one hand, impaired blood circulation affects the tissue trophism; on the other hand, the high density of blood vessels in the regenerating granulation tissue ensured acceleration of metabolic processes, which promoted healing and differentiation into coarse-fibrous connective tissue. Azatyan V. et al (2021) performed a morphological study of oral mucosal biopsies in patients with HBV, HCV and HIV that also revealed general morphological changes in the oral mucosa [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study

Azatyan

Yessayan

Sargsyan³

et al. 2022

IJERPH

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The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 and ɤ-INF in the oral fluid was determined by ELISA. Buccal mucosa and gums biopsies passed histological examination. An immunohistochemical study of mucous membrane biopsies was performed using monoclonal mouse antibodies to CD3+ and CD20+. Results: The HCV patients group included 96 (63.5% males), and the non-HCV group included 100 subjects (62.0% males) with lesions of the oral mucous membrane. The lesions of lips and oral mucosa were more frequent in HCV than in the non-HCV group—e.g., erosion (13.5% vs. 1%), cracks in the mouth corners (42.7% vs. 0%), changes in the oral mucosa surface (89.6% vs. 3.0%), hemorrhages (78.1% vs. 0%), etc. The pro-inflammatory IL-2 level was higher and anti-inflammatory IL-4 level was lower in HCV patients compared with those in the non-HCV group. Conclusions: Morphological changes developed in the microvasculature both worsen the tissue trophism and accelerate the healing with differentiation into coarse-fibrous connective tissue. Immunohistochemical findings indicated a decrease in local humoral immune response.

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“…32 A series of sections 5 μm thick were made from the blocks and stained with hematoxylin-eosin and picrofuchsin according to Van Gieson for a general assessment of the condition of the tissues under study. 31 It is known that the diagnosis and prognosis of the outcome of diseases is primarily based on the study of hematoxylin-eosin sections. Microspecimens were studied with a Primostar Zeiss trinocular microscope at 200, 400 and 1000x magnification.…”

Section: Methodsmentioning

confidence: 99%

“…30 Timely and effective diagnosis of various diseases of the oral mucosa still remains an important problem in dentistry, since they are characterized by a wide variety of both morphological structure and clinical manifestations. 1,31 It should be noted that in the available literature no information was found on a comparative one-time study of the state of the oral organs in HBV and HCV. In our opinion, this study will be promising for the development of methods for early diagnosis and comprehensive assessment of the dental status in patients with HBV and HCV with lesions of the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Morphological Features of Biopsy Samples of the Oral Mucosa in Patients With Viral Hepatitis B and C

Sahakyan,

Mkrtchyan,

Yessayan

et al. 2024

JBSMFS

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Background: Currently, diseases of the oral mucosa and periodontal disease are an important problem in dentistry. Studies of the oral cavity in chronic diffuse liver diseases are of great interest to clinicians since pathological processes developing in the liver, as a rule, lead to organic and functional disorders in the oral mucosa. Purpose: The aim of the study was to reveal the morphological features of biopsy samples of the oral mucosa in patients with HBV and HCV. Materials and methods: The study involved 95 patients with HBV, 96 patients with HCV with lesions of the oral cavity and periodontium, as well as 100 patients in the control group without HBV and without HCV, but with lesions of the oral cavity and periodontium. The age of the patients ranged from 21-64 years. In all the groups we examined, 20 morphological studies were carried out. Results: To study the dental status, patients' complaints and data from a clinical examination of the oral cavity were taken into account, which included: external examination of the lips and corners of the mouth, assessment of the condition of various parts of the oral mucosa. To confirm the results of clinical data, we conducted a morphological study of a biopsy sample of the oral mucosa. Biopsies were taken from the affected areas of the oral mucosa. Conclusion: During a pathomorphological study of OM in viral hepatitis B and C, inflammatory infiltration, circulatory disorders and dystrophic changes in the squamous epithelium were detected in all patients, fibrosis - in all patients with HCV. Lymphoplasmacytic infiltration was detected in almost all patients with HBV and HCV

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Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV

Cited by 4 publications

References 9 publications

Knowledge and Practices Regarding Oral Hygiene, Cariogenic Diet Intake, and Dental Check-Ups Among Registered Nurses in Nigeria: A Pilot Study

Knowledge and Practices Regarding Oral Hygiene, Cariogenic Diet Intake, and Dental Check-Ups Among Registered Nurses in Nigeria: A Pilot Study

Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study

Morphological Features of Biopsy Samples of the Oral Mucosa in Patients With Viral Hepatitis B and C

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