Assessment of Perceived Cost to the Patient and Other Barriers to Clinical Trial Participation

Weckstein, Douglas; Thomas, Christian A.; Emery, Ivette F.; Shea, Barbara F.; Fleury, Alison; White, Margaret; Chase, Elizabeth; Robinson, Cindy; Frazier, Stacey; Pilar, Christine

doi:10.1200/jop.2011.000236

Cited by 35 publications

(22 citation statements)

References 15 publications

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“…In Weinstein et al (43) survey of cancer patients eligible for clinical trials, the top 3 reasons for not participating were fear of adverse events, concern of random assignment of treatment, and cost. In the Penberthy et al survey (44), the top 3 reasons given for not wanting to participate in cancer clinical trials were extra cost and logistical problems, lack of interest in the trials, and avoidance of specific treatment.…”

Section: Discussionmentioning

confidence: 99%

Using registries to recruit subjects for clinical trials

Tan

Thomas

MacEachern

2015

Contemporary Clinical Trials

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Aim We studied the use of patient/disease registries to recruit potential subjects for prospective clinical trials - describing the number, types and major benefits of using this approach. Methods In December 2013, we conducted a focused database search in PubMed, EMBASE, and Web of Science for studies (English language only) that used registries to recruit subjects for clinical trials published in 2004-2013. Of the 233 unique citations identified, 21 used registries to recruit subjects - 10 papers and 11 abstracts. Pearling and search for subsequent full papers of the abstracts identified 4 more papers. Results Our analysis, based on these 25 citations, showed 14 are related to cancer, 3 to diabetes mellitus, 1 each to stroke, asthma, and celiac disease and 5 are disease neutral. Many types of registries (population-based cancer, quality improvement, disease-specific, web-based disease-neutral registries, local general practice registers, and national health database) are used to recruit subjects for clinical trials and uncover new knowledge. Overall, 16 registries are in the US, 4 in UK, 1 each in Canada, Spain, Australia and I in many countries. Registries can identify very large number of subjects for screening for eligibility for clinical trials, especially in very large trials, rare disease trials, and trials involving minority patients. Conclusions Registries can retrospectively identify very large numbers of potential subjects for screening for eligibility and enrollment in prospective clinical trials. This matching can lead to more timely recruitment and help solve a major problem in conducting clinical trials.

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Section: Discussionmentioning

confidence: 99%

Using registries to recruit subjects for clinical trials

Tan

Thomas

MacEachern

2015

Contemporary Clinical Trials

View full text Add to dashboard Cite

show abstract

“…The lack of insurance, which was often identified as a barrier to inclusion, cannot be considered in France, as most patients benefit from social insurance [5,24,25]. This could greatly explain the absence of any impact of deprivation on enrolment in our study.…”

Section: Discussionmentioning

confidence: 54%