Assessment of perfluorohexane sulfonic acid (PFHxS)-related compounds degradation potential: Computational and experimental approaches

Zhong, Hao‐Jie; Liu, Wen‐Cheng; Li, Ningqi; Ma, Donghui; Zhao, Chunyan; Li, Juan; Wang, Yawei; Jiang, Guibin

doi:10.1016/j.jhazmat.2022.129240

Cited by 15 publications

(5 citation statements)

References 44 publications

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“…Although FHxSA was detected in fish and mussel tissues, CF b could not be determined because it was not measured in groundwater. There is limited availability of fish metabolic transformation pathway data for PFAS, and uncertainties in the assumptions that microbial degradation or abiotic processes are adequate surrogates for fish metabolism. It generally is thought that the biotransformation of precursors ultimately results in terminal PFCA and PFSA products .…”

Section: Resultsmentioning

confidence: 99%

Uptake of Per- and Polyfluoroalkyl Substances by Fish, Mussel, and Passive Samplers in Mobile-Laboratory Exposures Using Groundwater from a Contamination Plume at a Historical Fire Training Area, Cape Cod, Massachusetts

Barber

Pickard

Alvarez

et al. 2023

Environ. Sci. Technol.

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Aqueous film-forming foams historically were used during fire training activities on Joint Base Cape Cod, Massachusetts, and created an extensive per- and polyfluoroalkyl substances (PFAS) groundwater contamination plume. The potential for PFAS bioconcentration from exposure to the contaminated groundwater, which discharges to surface water bodies, was assessed with mobile-laboratory experiments using groundwater from the contamination plume and a nearby reference location. The on-site continuous-flow 21-day exposures used male and female fathead minnows, freshwater mussels, polar organic chemical integrative samplers (POCIS), and polyethylene tube samplers (PETS) to evaluate biotic and abiotic uptake. The composition of the PFAS-contaminated groundwater was complex and 9 PFAS were detected in the reference groundwater and 17 PFAS were detected in the contaminated groundwater. The summed PFAS concentrations ranged from 120 to 140 ng L–1 in reference groundwater and 6100 to 15,000 ng L–1 in contaminated groundwater. Biotic concentration factors (CFb) for individual PFAS were species, sex, source, and compound-specific and ranged from 2.9 to 1000 L kg–1 in whole-body male fish exposed to contaminated groundwater for 21 days. The fish and mussel CFb generally increased with increasing fluorocarbon chain length and were greater for sulfonates than for carboxylates. The exception was perfluorohexane sulfonate, which deviated from the linear trend and had a 10-fold difference in CFb between sites, possibly because of biotransformation of precursors such as perfluorohexane sulfonamide. Uptake for most PFAS in male fish was linear over time, whereas female fish had bilinear uptake indicated by an initial increase in tissue concentrations followed by a decrease. Uptake of PFAS was less for mussels (maximum CFb = 200) than for fish, and mussel uptake of most PFAS also was bilinear. Although abiotic concentration factors were greater than CFb, and values for POCIS were greater than for PETS, passive samplers were useful for assessing PFAS that potentially bioconcentrate in fish but are present at concentrations below method quantitation limits in water. Passive samplers also accumulate short-chain PFAS that are not bioconcentrated.

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Section: Resultsmentioning

confidence: 99%

Uptake of Per- and Polyfluoroalkyl Substances by Fish, Mussel, and Passive Samplers in Mobile-Laboratory Exposures Using Groundwater from a Contamination Plume at a Historical Fire Training Area, Cape Cod, Massachusetts

Barber

Pickard

Alvarez

et al. 2023

Environ. Sci. Technol.

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“…The main research on antibiotics focuses on the study of resistance genes, especially in the context of adsorption and photocatalysis (Figure 5d). The production and use of toxic and harmful chemicals are the primary sources of CECs [31,32]. CECs may originate from industrial waste, municipal waste, agricultural waste, hospital, and laboratory wastewater [33].…”

Section: Sources and Environmental Behavior Of Cecsmentioning

confidence: 99%

“…CECs may originate from industrial waste, municipal waste, agricultural waste, hospital, and laboratory wastewater [33]. They can enter the environment through various point sources (i.e., industrial, municipal, and hospital wastewater treatment The production and use of toxic and harmful chemicals are the primary sources of CECs [31,32]. CECs may originate from industrial waste, municipal waste, agricultural waste, hospital, and laboratory wastewater [33].…”

Section: Sources and Environmental Behavior Of Cecsmentioning

confidence: 99%

Systematic Review of Contaminants of Emerging Concern (CECs): Distribution, Risks, and Implications for Water Quality and Health

Feng,

Deng,

Yang

et al. 2023

Water

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The introduction of contaminants of emerging concern (CECs) into the environment has raised concerns due to the significant risks they pose to both ecosystems and human health. In this sys-tematic review, we investigate research trends on CECs worldwide over the past 10 years, focus-ing on four critical aspects: (i) the identification and distribution of typical CECs across various media, (ii) the sources and environmental behavior of CECs, (iii) the implications of CECs expo-sure on human health, and (iv) risk assessment and control measures for CECs. The review re-veals a comprehensive understanding of the typical types and distribution of CECs in different environmental media, shedding light on their prevalence and potential impact on ecosystems. Furthermore, insights into the sources and behavior of CECs provide crucial information for de-vising effective strategies to mitigate their release into the environment. By examining the health effects of EC exposure, we highlight the importance of considering potential risks to human well-being. This aspect of the review emphasizes the significance of monitoring and managing CECs to safeguard public health. The review also synthesizes the advancements in risk assessment methodologies and control measures for CECs, which are essential for developing comprehensive regulations and guidelines to manage these contaminants effectively. Drawing from the findings, we identify future research directions for CECs in aquatic environments.

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“…2−4 Given their adverse environmental and biological effects, several PFAS, including perfluorooctanesulfonic acid (PFOS), perfluorooctanic acid (PFOA), and perfluorohexanesulfonic acid (PFHxS) were included in Annex A or B of the persistent organic pollutant list of the Stockholm Convention in 2009, 2019, and 2021, respectively. 5,6 Nevertheless, many other emerging PFAS with different chemical structures (insertion and replacement by other atoms or functional groups) have been produced for use in commerce, including electronic products. For example, chlorinated polyfluorinated ether sulfonates (Cl-PFESAs) with the trade name F-53B have been used in the metal plating industry as an alternative to PFOS in China.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Per- and polyfluoroalkyl substances (PFAS) have been widely used for almost 7 decades in various commercial and consumer products due to their unique characteristics . Toxicological studies have shown that exposure to PFAS results in hepatotoxicity, neurotoxicity, endocrine disrupting effects, and carcinogenicity. − Given their adverse environmental and biological effects, several PFAS, including perfluorooctanesulfonic acid (PFOS), perfluorooctanic acid (PFOA), and perfluorohexanesulfonic acid (PFHxS) were included in Annex A or B of the persistent organic pollutant list of the Stockholm Convention in 2009, 2019, and 2021, respectively. , Nevertheless, many other emerging PFAS with different chemical structures (insertion and replacement by other atoms or functional groups) have been produced for use in commerce, including electronic products. For example, chlorinated polyfluorinated ether sulfonates (Cl-PFESAs) with the trade name F-53B have been used in the metal plating industry as an alternative to PFOS in China. , Perfluorophosphoric acids (PFPAs) have been reported to be used as antifoaming and wetting agents in consumer products .…”

Section: Introductionmentioning

confidence: 99%

First Evidence of Prenatal Exposure to Emerging Poly- and Perfluoroalkyl Substances Associated with E-Waste Dismantling: Chemical Structure-Based Placental Transfer and Health Risks

Zhang

Wei

et al. 2022

Environ. Sci. Technol.

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Limited information is available about prenatal exposure to per-and polyfluoroalkyl substances (PFAS) in electronic waste (e-waste) recycling sites. In this study, we determined 21 emerging PFAS and 13 legacy PFAS in 94 paired maternal and cord serum samples collected from an e-waste dismantling site in Southern China. We found 6:2 fluorotelomer sulfonate (6:2 FTSA), 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), and perfluorooctanephosphonate (PFOPA) as the major emerging PFAS, regardless of matrices, at median concentrations of 2.40, 1.78, and 0.69 ng/mL, respectively, in maternal serum samples, and 2.30, 0.73, and 0.72 ng/mL, respectively, in cord serum samples. Our results provide evidence that e-waste dismantling activities contribute to human exposure to 6:2 FTSA, 6:2 Cl-PFESA, and PFOPA. The trans-placental transfer efficiencies of emerging PFAS (0.42−0.94) were higher than that of perfluorooctanesulfonic acid (0.37) and were structure-dependent. The substitution of fluorine with chlorine or hydrogen and/or hydrophilic functional groups may alter trans-placental transfer efficiencies. Multiple linear regression analysis indicated significant associations between maternal serum concentrations of emerging PFAS and maternal clinical parameters, especially liver function and erythrocyte-related biomarkers. This study provides new insights into prenatal exposure to multiple PFAS in e-waste dismantling areas and the prevalence of emerging PFAS in people living near the sites.

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Assessment of perfluorohexane sulfonic acid (PFHxS)-related compounds degradation potential: Computational and experimental approaches

Cited by 15 publications

References 44 publications

Uptake of Per- and Polyfluoroalkyl Substances by Fish, Mussel, and Passive Samplers in Mobile-Laboratory Exposures Using Groundwater from a Contamination Plume at a Historical Fire Training Area, Cape Cod, Massachusetts

Uptake of Per- and Polyfluoroalkyl Substances by Fish, Mussel, and Passive Samplers in Mobile-Laboratory Exposures Using Groundwater from a Contamination Plume at a Historical Fire Training Area, Cape Cod, Massachusetts

Systematic Review of Contaminants of Emerging Concern (CECs): Distribution, Risks, and Implications for Water Quality and Health

First Evidence of Prenatal Exposure to Emerging Poly- and Perfluoroalkyl Substances Associated with E-Waste Dismantling: Chemical Structure-Based Placental Transfer and Health Risks

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