Assessment of Peripheral Diabetic Neuropathy: New versus Conventional Methods

Inceu, Georgeta; Vereşiu, Ioan Andrei

doi:10.1007/978-3-319-07653-9_36

Cited by 2 publications

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“…The 2000 Hz stimulus selectively induces large myelinated fiber responses and the 5 Hz stimulus selectively triggers unmyelinated fiber responses [ 14 ]. The device quantifies in a quickly and painless manner the conduction and functional integrity of the large and small myelinated and small unmyelinated sensory nerve fibers [ 15 ]. The device produces transcutaneous electrical stimuli through a pair of gold plated electrodes to quantify neuroselective CPT values.…”

Section: Current Perception Threshold Using the Neurometer® - Descripmentioning

confidence: 99%

“…We also conducted a study on 60 patients with type 2 diabetes, who were divided in three groups based on their diabetes durations (<5 years, 5–10 years, >10 years), and the patients were assessed for the presence of DPN using two different methods: Semmes - Weinstein Monofilament testing (SWMT) and rapid-current perception threshold measurement using the Neurometer® [ 15 ].…”

Section: Using the Neurometer® For The Screening And Diagnosis Of Diamentioning

confidence: 99%

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Measurement of Current Perception Thresholds Using the Neurometer® – Applicability in Diabetic Neuropathy

Inceu

Vereşiu

2015

Medicine and Pharmacy Reports

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The incidence of diabetes mellitus is continuously growing worldwide, while the specific chronic complications that it induces have a negative impact on life expectancy andquality, entailing extremely high costs of healthcare services. Diabetic peripheral neuropathy is one of the most common chronic complications of diabetes, affecting almost half of diabetic people during life.This review aims at summarizing the evidence on the advantages and the usefulness of current perception threshold measurement for peripheral diabetic neuropathy assessment. Among the different methods used for the screening and diagnosis of diabetic neuropathy, measurement of current perception threshold using the Neurometer® has the ability to assess three sub-types of nerve fiber by producing transcutaneous electrical stimuli at frequencies of 2000, 250 and 5 Hz.Current evidence shows that this method provides a useful, noninvasive evaluation technique of patients with peripheral nervous system disorders, being able to detect neuropathy in the earliest and asymptomatic stages.

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Section: Current Perception Threshold Using the Neurometer® - Descripmentioning

confidence: 99%

Section: Using the Neurometer® For The Screening And Diagnosis Of Diamentioning

confidence: 99%

Measurement of Current Perception Thresholds Using the Neurometer® – Applicability in Diabetic Neuropathy

Inceu

Vereşiu

2015

Medicine and Pharmacy Reports

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“…Although obesity is closely associated with IGT, our study is not comparable with the findings of the abovementioned research, due to the fact that we did not take the effect of glucose intolerance into account, nor did we make a comparison with a healthy control group (36). Based on the results of a study using both the neurometer and Semmes-Weinstein monofilament testing (SWMT) for the evaluation of DPN, Inceu et al reported that PN is more frequent in diabetic individuals with >10 years of disease duration than in patients who have been suffering from diabetes for <5 years (27). Since the duration of diabetes was not considered in our study, our result of the comparison analysis cannot be actually compared to that of Inceu et al The involvement of controlled, well-treated participants without clinical signs of PN may also explain why no significant differences were found concerning the CPT values between groups.…”

Section: Discussionmentioning

confidence: 99%

“…Measurement of current perception threshold (CPT) applying a neurometer (NM-01/CPT; MSB-MET Ltd., Hungary) was also performed to detect peripheral nerve dysfunction. The neurometer was used to quantify both the conduction and the functional integrity of the large and small myelinated as well as small unmyelinated sensory nerve fibers (27).…”

Section: Nerve Conducting Studies Applying Neurometermentioning

confidence: 99%

Imaging with [^99mTc]HMPAO – a novel perspective: investigation of [^99mTc]HMPAO leg muscle uptake in metabolic diseases

et al. 2021

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Background Sensitive imaging modalities in the diagnosis of microcircular complications of the lower extremities induced by metabolic diseases are becoming a focus of interest. Purpose To investigate the [99mTc]HMPAO uptake of the legs in type 2 diabetes mellitus (T2DM) and obesity, and to search for associations with clinical parameters and nerve conducting studies. Material and Methods A total of 57 patients with controlled T2DM and 46 obese participants without DM were enrolled in the study. [99mTc]HMPAO SPECT/CT examinations were performed to evaluate the radiopharmaceutical accumulation of the legs. For the quantitative assessment of tracer uptake, standardized uptake value (SUVpeak) was measured in fixed spheric volumes of interest placed on both sural muscles on the attenuation-corrected images. Measurement of current perception threshold applying Neurometer (NM-01/CPT) was used to evaluate peripheral nerve dysfunction. Laboratory parameters assessing the glucose homeostasis of the study participants were also measured. Results In the diabetic group, significantly lower leg SUV values were detected compared to the non-DM obese group (median: 0.517 vs. 0.607; P < 0.001). Body mass index (BMI) ( P < 0.0001), age ( P = 0.0283), HbA1c ( P = 0.0068), and glucose level ( P = 0.0044) proved to be significant predictors of muscle tracer uptake. Neurometer studies showed positive correlation with HbA1c levels in the T2DM group ( P = 0.0002). Conclusion We assume that [99mTc]HMPAO uptake of leg muscles is associated with microcirculation, so quantitative [99mTc]HMPAO SPECT/CT might be a sensitive method for evaluating lower limb microvascular alterations. BMI, age, HbA1c, and glucose level may be significant predictors of peripheral vascular abnormalities triggered by metabolic disturbances.

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Assessment of Peripheral Diabetic Neuropathy: New versus Conventional Methods

Cited by 2 publications

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Measurement of Current Perception Thresholds Using the Neurometer® – Applicability in Diabetic Neuropathy

Measurement of Current Perception Thresholds Using the Neurometer® – Applicability in Diabetic Neuropathy

Imaging with [^99mTc]HMPAO – a novel perspective: investigation of [^99mTc]HMPAO leg muscle uptake in metabolic diseases

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Assessment of Peripheral Diabetic Neuropathy: New versus Conventional Methods

Cited by 2 publications

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Measurement of Current Perception Thresholds Using the Neurometer® – Applicability in Diabetic Neuropathy

Measurement of Current Perception Thresholds Using the Neurometer® – Applicability in Diabetic Neuropathy

Imaging with [99mTc]HMPAO – a novel perspective: investigation of [99mTc]HMPAO leg muscle uptake in metabolic diseases

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Imaging with [^99mTc]HMPAO – a novel perspective: investigation of [^99mTc]HMPAO leg muscle uptake in metabolic diseases