Assessment of Peste Des Petits Ruminants Antibodies in Vaccinated Yankasa Pregnant Ewes from Nigeria and the Duration of Maternal Immunity in Their Lambs

Olaolu, Olushola Samuel; Kazeem, H. M.; Adamu, Jibril; Markus, Talatu Patience; Woma, Timothy Yusufu

doi:10.52547/vacres.8.1.47

Cited by 3 publications

(3 citation statements)

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“…Similar [21]. In these studies, differences in the age at which kids should be vaccinated may be related to the types and breeds of experimental animals used in the studies.…”

Section: Discussionmentioning

confidence: 93%

Assessment of Peste des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determination of the Decreasing Trend of Maternal Immunity in Their Lambs

Amanova,

Turyskeldy,

Kondybaeva

et al. 2023

Viruses

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In this article, we first assessed peste des petits ruminants (PPR) antibodies in vaccinated pregnant ewes of Kazakh breed fine-fleeced immunized with the PPR vaccine and the duration of maternal immunity in their lambs. Ewes in the last trimester of pregnancy and gestation were immunized with a vaccine from the Nigeria 75/1 strain of the PPR virus (PPRV) produced by the Research Institute of Biological Safety Problems (RIBSP), Kazakhstan. Serum samples from lambs born from vaccinated and unvaccinated ewes were collected a week after birth and at intervals of 7 days for 18 weeks after birth. Serum samples collected from lambs were tested for PPR antibodies using competitive ELISA and virus neutralization test (VNT). Maternal antibodies (MAs) in lambs born from vaccinated ewes were detected for up to 18 weeks, with a tendency to decrease starting at week 14, and by the end of the experiment receded below the protective level (<1:8). In the blood serum of a 14-week-old lamb with MAs (1:8), post vaccination with a field dose (103 TCID50) of the vaccine against PPR, the titers of protective antibodies against PPRV increased to 1:16 on day 14 post vaccination, and the lamb was protected from infection with the field PPRV. A lamb of the same age with MAs in the 1:8 titer was 100% protected from infection with the field PPRV. Therefore, it is recommended that lambs of the Kazakh fine-wool breed be immunized from the age of 14 weeks or older to avoid a period of susceptibility.

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“…Similar [21]. In these studies, differences in the age at which kids should be vaccinated may be related to the types and breeds of experimental animals used in the studies.…”

Section: Discussionmentioning

confidence: 93%

Assessment of Peste des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determination of the Decreasing Trend of Maternal Immunity in Their Lambs

Amanova,

Turyskeldy,

Kondybaeva

et al. 2023

Viruses

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show abstract

“…By the study of Kazeem et al. ( 2021 ), the susceptibility window to PPR in lambs born from ewes vaccinated with the attenuated live PPR vaccine of the Nigerien 75.1 strain was determined between 8 and 10 weeks and 9 weeks old, announced as a good time to administer the first PPR vaccine in lambs. The results of this study are consistent with the present study.…”

Section: Discussionmentioning

confidence: 99%

“…This study was performed in a closed farm with 1500 Saanen goats during period from July 2021 to July 2022. The sample size was determined based on previous studies (Balamurugan et al., 2012 ; Kazeem et al., 2021 ; Markus et al., 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Determining the decreasing trend of maternal immunity against small ruminant morbillivirus in goat kids

Abdollahi

Lotfi

Lotfollahzadeh

et al. 2023

Veterinary Medicine & Sci

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Background: Small ruminant morbillivirus (SRMV) is the etiological agent of Peste des petits ruminants (PPR) disease. PPR is one of the most important viral diseases of small ruminant husbandry. In the endemic countries, vaccination is the main way to control this disease. Administering the first PPR vaccine in goat kids requires decreased maternal immunity. Objective:The aim of this study was to determine the decreasing trend of maternal immunity against SRMV in goat kids born from vaccinated goats.Methods: Twenty Saanen goat kids were studied in two groups including control (n = 5, receiving colostrum from unvaccinated goats) and treatment (n = 15, receiving colostrum from vaccinated goats). Virus neutralisation (VN) test was used to evaluate serum specific antibodies against SRMV in goat kids from birth to 100 days of age. Results:The first goat kid (n = 1) in the treatment group was seronegative at the age of 28 days. All the goat kids were seronegative at the age of 100 days. The average serum titre of the goat kids at the age of 70-100 days became negative.Conclusions: Some goat kids became seronegative before reaching the age of receiving the first PPR vaccine. The age of 70-100 days could be a good age range to give the first dose of PPR vaccine to the goat kids, but more studies were needed on the effectiveness of this vaccine at this age range.

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Assessment of Peste Des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determining the Decreasing Trend of Maternal Immunity in Their Lambs

Amanova,

Turyskeldy,

Kondybaeva

et al. 2023

Preprint

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In this article, we first assessment of peste des petits ruminants (PPR) antibodies in vaccinated pregnant ewes of Kazakh breed fine-fleeced immunized with the PPR vaccine and the duration of maternal immunity in their lambs. Ewes in the last trimester of pregnancy of gestation were immunized with a vaccine from the Nigeria 75/1 strain of the PPR virus (PPRV) produced by the Research Institute of Biological Safety Problems (RIBSP), Kazakhstan. Serum samples from lambs born from vaccinated and unvaccinated ewes were collected a week after birth and at intervals of 7 days for 18 weeks after birth. Serum samples collected from lambs were tested for PPR antibodies using competitive ELISA and Virus neutralization test (VNT). Maternal antibodies (MAs) in lambs born from vaccinated ewes were detected up to 18 weeks with a tendency to decrease starting at week 14 and by the end of the experiment receded below the protective level (&lt;1:8). In the blood serum of a 14-week-old lamb with MAs (1:8), post vaccination with a field dose (103 TCID50) of the vaccine against PPR, the titers of protective antibodies to the PPRV increased to 1:16 on 14 day post vaccination and lamb protected from infection upon field PPRV. A lamb of the same age with MAs in the 1:8 titer was 100% protected from infection with the field PPRV. Therefore, it is recommended that lambs of the Kazakh fine-wool breed be immunized from the age of 14 weeks or older to avoid a period of susceptibility.

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Assessment of Peste Des Petits Ruminants Antibodies in Vaccinated Yankasa Pregnant Ewes from Nigeria and the Duration of Maternal Immunity in Their Lambs

Cited by 3 publications

References 0 publications

Assessment of Peste des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determination of the Decreasing Trend of Maternal Immunity in Their Lambs

Assessment of Peste des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determination of the Decreasing Trend of Maternal Immunity in Their Lambs

Determining the decreasing trend of maternal immunity against small ruminant morbillivirus in goat kids

Assessment of Peste Des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determining the Decreasing Trend of Maternal Immunity in Their Lambs

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