Assessment of pharmacokinetics for microvessel proliferation by DCE-MRI for early detection of physeal bone bridge formation in an animal model

Neumayer, Bernhard; Amerstorfer, Eva E.; Lindtner, Richard A.; Wadl, Elisabeth; Scheurer, Eva; Weinberg, Annelie‐Martina; Stollberger, Rudolf

doi:10.1007/s10334-017-0615-2

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…After the initial inflammatory response, the fibrogenic phase appears on days 3–7 after the GP injuries and involves the fibrous vinmentin-immunopositive mesenchymal cells gathering at the injured site. These cells may contain mesenchymal stem cells (MSCs), osteoprogenitor, and chondroprogenitor cells, which are confirmed to be vital for the fracture repair process ( Macsai et al, 2011 ; Neumayer et al, 2017 ; Figure 3B ). In the fibrogenic phase, growth factors, such as FGF-2 and platelet derived growth factor (PDGF) play an important role ( Zhou et al, 2004 ; Shaw et al, 2018 ).…”

Section: The Mechanism Of the Gp Damagementioning

confidence: 99%

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries.

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Section: The Mechanism Of the Gp Damagementioning

confidence: 99%

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Quantitative Multiparametric MRI May Augment the Response to Radiotherapy in Mid-Treatment Assessment of Patients with Esophageal Carcinoma

Xie

Pang³

et al. 2019

Oncol Res Treat

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Objective: The purpose of this study was to assess the mid-treatment response to radiotherapy (RT) using dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in patients with esophageal cancer (EC). Methods: 42 patients with squamous EC were prepared for DCE-MRI and DWI scans both before treatment (NRT) and after the fifth radiotherapy (5th RT). The patients were classified into two groups (complete response [CR] and partial response [PR]) according to tumor regression after treatment. The quantitative parameters of DCE-MRI (K^trans, Kep, Ve, and ADC) were measured. A receiver operating characteristic curve (ROC) was used to detect the efficiency of the above parameters. Results: After 1 month of RT, 29 patients were classified as CR and 11 patients were classified as PR. In the NRT group, the p values of K^trans, Kep, Ve, and ADC were 0.004, 0.078, 0.0008, and <0.0001, respectively. After the 5th RT, the p values of the above parameters were <0.001, 0.005, 0.108, and 0.365, respectively. In the NRT group, the areas under the ROC curves of K^trans, Ve, and ADC were 0.790, 0.617, and 0.737; the sensitivity values were 89.3, 92.5, and 90.0%; the specificity values were 69.4, 27.5, and 50.0%. In the 5th RT group, the areas under the ROC curves of K^trans and Kep were 0.816 and 0.804; the sensitivity values were 71.2 and 95.0%; the specificity values were 81.6 and 50.0%. Conclusion: DCE-MRI combined with DWI is effective in the early prediction of radiotherapeutic response of EC after the 5th RT other than after the traditional final treatment.

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Assessment of pharmacokinetics for microvessel proliferation by DCE-MRI for early detection of physeal bone bridge formation in an animal model

Cited by 2 publications

References 47 publications

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Quantitative Multiparametric MRI May Augment the Response to Radiotherapy in Mid-Treatment Assessment of Patients with Esophageal Carcinoma

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