Assessment of Photoprotective, Antioxidant and Anti-Skin Cancer Activities of Leaf Extracts of Certain Medicinal Plants

Abstract

P LANT extracts acquiring antioxidant potential have recently been used for topical applications for significant protection against ultra violet (UV)-induced sunburn. The current study was conducted for screening Pluchea discoridis (Asteracea), Lawsonia inermis (Lythraceae), Aloe vera (Liliaceae) and Eucalyptus camaldulensis (Myrtaceae) for their photoprotective, antioxidant and anti-skin cancer properties.Multivariate data analysis based on spectrophotometric evaluation of major secondary metabolites was performed. Each plant had its specific pattern of metabolites. P. discoridis and E. camaldulensis were separated from other plants due to their high content of secondary metabolites where P. discoridis was discriminated by high content of flavonoids and saponins. E. camaldulensis, was discriminated by high content of phenolics and tannins.Different concentrations of plant extracts were read for absorbance at UVB spectrum. Sun protection factors (SPFs) were calculated. The highest concentration (10mg/mL) of P. discoridis extract had the highest SPF, i.e., 23.94± 0.98.The antioxidant activity using 2,2-Diphenyl-1-picryl-hydrazyl (DPPH) assay revealed that P. discoridis and L. inermis extracts had the best free radical scavenging activity with DPPH at 100µg/mL of 85.69± 1.8 and 85.35± 2.5%, respectively.Human skin tumor cell line (A431) was incubated with the plant extracts. P. discoridis had the best anti-skin cancer activity of lowest LC 50 value. The effect induced by the P. discoridis extract was also identical to that of the standard chemotherapeutic drug (doxorubicin). The present study revealed that P. discoridis is a promising plant for use in sunscreen formulations and anti-skin cancer treatment.

The Potential of Grapevine Leaf Extract in Treating Hyperpigmentation

“…In this study, we obtained comparatively high values of SPF (ranging between 23 and 37), even though we used a relatively low extract concentration (1.5 mg/L). At the same time, summarizing a comparison between different plant species, a maximum SPF of 24 was found [69].…”

“…Our work is the first to evaluate the anti-hyperpigmentation potential of a large set of grape varieties. Other efforts show different concentrations of mixed red vine leaf extract (RVLE) [45], a single variety using different extraction methods [46], or a comparison between plant species [69]. In addition, our work compares European and Israeli varieties originating from domestication efforts in two areas with very different eco-geographic conditions.…”

Nutritional and Medicinal Potential of Bottle Gourd (Lageneria siceraria): A Mini Review

“…Plants are major sources for natural products and plant-based medicaments are the basis of many of the modern pharmaceuticals (Mohamed & Sorour, 2020;Behera et al, 2021). The selection of the right scientific technique and systemised approach to the biological analysis of plant products, based on their utilisation in traditional medicines, is the perfect development of new plant-originated drugs.…”

Chemical composition and photoprotective potential of aqueous extract from Casearia sylvestris var. lingua (Cambess.) Eichler leaves

“…The study by Mohamed and Sorour [5] obtained a correlation between the photoprotective activity and the presence of tannins in the extract of 4 medicinal plants (Pluchea discoridis, Lawsonia inermis, Aloe vera and Eucalyptus camaldulensis).…”