Assessment of physical growth, some oxidative stress biomarkers and vitamin D status in children with Familial Mediterranean Fever

Zaki, Moushira Erfan; El-Bassyouni, Hala T.; Abdallah, Hanaa Reyad; Yousef, Walaa; Youness, Eman R.; Mohamed, Gamal A.; Ramadan, Abeer

doi:10.1016/j.mgene.2018.06.010

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…The increased oxidative stress has been demonstrated in FMF by various researches. Furthermore, ROS secreted in activated inflammatory cells through cytokines results in oxidative stress in FMF patients [ 5 ]. Nonetheless, more research examining oxidative stress markers is required to confirm this prediction.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated IL-6, IL-10, serum-soluble IL-2 receptor, and TNF-α levels are determined throughout or between acute FMF attacks in various researches [ 4 ]. In addition, studies have revealed that oxidative stress deepens in FMF patients throughout the attack and the periods without an attack [ 5 ]. In spite of the apparent advancements in examining FMF pathogenesis, the reasons for its attacks’ periodicity and self-limited nature are still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

et al. 2022

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Background Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by short, repeated, and self-limiting attacks of fever and serositis. Subclinical inflammation can persist in the periods with no symptoms and result in amyloidosis even with colchicine treatment. Neopterin and calprotectin have been considered essential players in inflammation and immune response. Aim The study was aimed to measure serum levels of neopterin and calprotectin in patients with FMF in the attack-free period. Methods A total of 160 participants were recruited from the rheumatology department in this single-center, case–control study. Individuals having the inclusion criteria were divided into healthy controls ( n = 80) and FMF ( n = 80). The laboratory data were acquired from the electronic registration database. Serum calprotectin and neopterin were measured with ELISA test kits. FMF patients and healthy controls’ laboratory findings were compared. Results FMF patients’ serum red cell distribution width (RDW), calprotectin, and neopterin values were significantly higher compared to healthy controls. There were no statistically significant differences between calprotectin and neopterin regarding gender, family history, and colchicine response of the FMF patients. Conclusions Calprotectin, neopterin, and RDW can be valuable marker candidates to be used in the follow-up of subclinical inflammation in FMF patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

et al. 2022

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“…In previous studies, vitamin D levels in pediatric FMF patients [ 13 – 15 , 24 , 25 ] were lower than controls; it has been reported that it is higher in boys than in girls [ 26 ]. Kozan et al [ 27 ], found to be similar vitamin D levels between patients with FMF and controls.…”

Section: Discussionmentioning

confidence: 99%

“…Reactive oxygen species (ROS) produced in activated inflammatory cells by cytokines cause oxidative stress in patients with FMF [ 3 , 10 ]. The low serum paraoxonase (PON1) levels and increased lipid peroxidation during the attack-free period of FMF lead to the continuity of oxidative stress [ 25 , 33 ]. Although Savran et al [ 34 ] detected higher TOS in adult patients with FMF compared to control, TAS results were found to be similar.…”

Section: Discussionmentioning

confidence: 99%

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Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status

Alesh¹,

Keti²,

Kısaarslan³

et al. 2021

Turk J Med Sci

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Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investigate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period. Materials and methods:In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included in the study. Patients were grouped according to their vitamin D status (<20, 20-29, and 30-100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status.Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was observed between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥0.640) and high TOS levels were negatively associated with vitamin D levels. Conclusion:Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF during an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.

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Carotid intima-media thickness, lipid profile, serum amyloid A and vitamin D status in children with familial Mediterranean fever

Mohamed

El-Bassyouni

Elwan

et al. 2020

The Egyptian Rheumatologist

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Assessment of physical growth, some oxidative stress biomarkers and vitamin D status in children with Familial Mediterranean Fever

Cited by 7 publications

References 24 publications

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status

Carotid intima-media thickness, lipid profile, serum amyloid A and vitamin D status in children with familial Mediterranean fever

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