The use of excessive chemicals in agriculture can cause harm to the environment and human health. Sustainable agriculture systems promote agroecological practices to reduce chemical use and promote environmental and human health. However, there is a lack of data on the status of chemical use and the adoption of agroecological practices in the Fez-Meknes region, which is a significant national vegetable production area. To address this gap, we conducted cross-sectional surveys with 603 farmers to analyze their practices, behaviors, and knowledge regarding chemical and bio-product use, as well as the risks to crops, health, and the environment. Additionally, we aimed to diagnose the diffusion of agroecological practices and identify the most relevant obstacles and motivations for adoption. Our results indicate that a majority of farmers (95%) use chemicals throughout the production process but lack a good understanding of their use and associated risks. However, farmers do have access to alternative practices such as crop rotation (99.67%), manure (96.35%), drip irrigation (74.46%), and intercropping (69%). The success of these practices among farmers was a significant motivation for their adoption (50%), whereas the difficulties of managing pests and diseases without pesticides (73.2%) and the lack of technical advice and support (70.8%) were the main barriers to adoption. In conclusion, our study highlights the need for training and financial encouragement from the state to promote healthy and eco-friendly farming practices. This research provides valuable insights into the current status of chemical use and the adoption of agroecological practices in the Fez-Meknes region, which can inform policy decisions and promote sustainable agriculture practices for the future.