Assessment of Plasma Endostatin Levels in Patients with Acute Myeloblastic and Lymphoblastic Leukemia

Abstract

In this study, we evaluated the plasma levels of endostatin (PE) and its prognostic importance in patients with acute myeloblastic (AML) and lypmhoblastic leukemia (ALL). We therefore analyzed plasma levels of endostatin before the chemotherapy and during the complete remission period in adult ALL and AML patients. The PE levels of the control group were significantly lower than both cases with ALL and AML. The patients with AML during remission had significantly higher PE levels than the levels at initial diagnosis. No statistically significant difference was detected in patients with ALL. In addition, the survival rates of the cases with ALL whose PE levels are higher than 2.5 ng/ml, are significantly lower. Our results suggest that the elevated plasma levels of endostatin during the remission in patients with AML imply the intensity of angiogenesis inhibition during the remission. Furthermore our findings in ALL patients suggest that endostatin levels may predict the overall survival of these patients.Keywords: Acute myeloblastic leukemia, Acute lymphoblastic leukemia, Angiogenesis, Endostatin ÖZET Akut Myeloblastik ve Lenfoblastik Lösemili Hastalarda Plazma Endostatin Düzeylerinin De¤erlendirilmesiBu çal›flmada akut myeloblastik (AML) ve akut lenfoblastik lösemili (ALL) hastalarda plazma endostatin (PE) düzeylerini ve prognostik anlam›n› de¤erlendirdik. Bu amaçla eriflkin ALL ve AML hastalar›nda kemoterapi öncesi ve komplet remisyon s›ras›nda plazma endostatin düzeylerini analiz ettik. Kontrol grubunun plazma endostatin (PE) düzeyi hem ALL hem de AML hastalar›na göre istatistiksel olarak anlaml› oranda daha düflüktü. AML'li hastalarda remisyon s›ras›ndaki PE düzeyleri tan› an›na göre anlaml› olarak daha yük-sekti, ALL'li hastalarda istatistiksel olarak anlaml› bir fark tespit edilmedi. Ayr›ca 2,5 ng/ml'nin üzerinde PE düzeylerine sahip ALL hastalar›nda yaflam süresi anlaml› olarak daha düflüktü. AML olgular›nda remisyon s›ras›nda endostatin düzeylerinin yüksek olmas› remisyon sürecinde anjiogenez inhibisyonunun yo¤unlu¤unu gösterebilir. Ayr›ca bulgular›m›z ALL'de endostatin düzeylerinin toplam yaflam süresini ön görmede etkili olabilece¤ini düflündürmüfltür.

Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children

“…In addition, the dominant model, which groups these 2 subpopulations, suggests a similar behavior. The activity of COL18A1 rs2274808 was further validated by a study which determined that a defect in COL18A1 would change endostatin synthesis in a Salvadorian population (Mahajan et al, 2010 ), consequently leading to an antiangiogenic disorder, such as Knoblock syndrome and ALL; however, some authors have indicated that children with ALL have variable levels of endostatin (Dagdas et al, 2011 ), which makes it difficult to accurately explain its relationship with the disease (Schneider et al, 2007 ).…”