Assessment of Plasma level of Nesfatin-1 in newly diagnosed Type 2 Diabetic patients

Abstract

Introduction: Diabetes mellitus type 2 (formerly non insulin-dependent diabetes mellitus (NIDDM) is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance and relative lack of insulin. Aims of the Work: The aim of the present study is assessment of plasma level of nesfatin-1 and its association with various metabolic parameters in newly diagnosed type 2 diabetic patients. Subjects and Methods: This study included 90 Patients were selected from those coming to Minia University hospital diabetes and outpatient clinics known to have newly diagnosed Diabetes Mellitus, diagnosed according to 2017 American Diabetes association (ADA) criteria. Results: This study was conducted on 90 persons our selected from our diabetic outpatient clinic and outpatient clinic of internal medicine .All subjected were divided into three groups. Discussion: Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. (ADA 2013). Conclusion and recommendations:The novelty of our study is that we showed, for the first time, significantly lower nesfatin-1 levels in diabetic patients (Type 2 DM) but less lower in prediabetic patients (IGT). Nesfatin-1 is a newly identified polypeptide probably involved, in the regulation of food intake. It is important to clarify the relationships between nesfatin-1 and insulin resistance with regard to diabetes. To elucidate its physiological role further studies are required.