Assessment of portal hypertension and high-risk oesophageal varices with liver and spleen three-dimensional multifrequency MR elastography in liver cirrhosis

Ronot, Maxime; Lambert, Simon A.; Elkrief, Laure; Doblas, Sabrina; Rautou, Pierre‐Emmanuel; Castéra, Laurent; Vilgrain, Valérie; Sinkus, Ralph; Beers, Bernard E. Van; Garteiser, Philippe

doi:10.1007/s00330-014-3124-y

Cited by 91 publications

(103 citation statements)

References 37 publications

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“…Indeed, studies suggest that liver fibrosis stage mainly correlates with tissue elasticity, whereas inflammation grade mainly correlates with wave scattering coefficient (Fig. 4) and portal hypertension degree with liver and spleen viscosity [122][123][124].…”

Section: Diffuse Liver Diseasesmentioning

confidence: 99%

New imaging techniques for liver diseases

Beers

Daire

Garteiser

2015

Journal of Hepatology

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111

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Newly developed or advanced methods of ultrasonography and MR imaging provide combined anatomical and quantitative functional information about diffuse and focal liver diseases. Ultrasound elastography has a central role for staging liver fibrosis and an increasing role in grading portal hypertension; dynamic contrast-enhanced ultrasonography may improve tumor characterization. In clinical practice, MR imaging examinations currently include diffusion-weighted and dynamic MR imaging, enhanced with extracellular or hepatobiliary contrast agents. Moreover, quantitative parameters obtained with diffusion-weighted MR imaging, dynamic contrast-enhanced MR imaging and MR elastography have the potential to characterize further diffuse and focal liver diseases, by adding information about tissue cellularity, perfusion, hepatocyte transport function and visco-elasticity. The multiparametric capability of ultrasonography and more markedly of MR imaging gives the opportunity for high diagnostic performance by combining imaging biomarkers. However, image acquisition and post-processing methods should be further standardized and validated in multicenter trials.

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Section: Diffuse Liver Diseasesmentioning

confidence: 99%

New imaging techniques for liver diseases

Beers

Daire

Garteiser

2015

Journal of Hepatology

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111

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“…Magnetic resonance elastography (MRE) has the theoretical advantage over TE of assessing liver and splenic stiffness across a larger tissue area. In 36 patients with cirrhosis, MRE-measured loss modulus of the liver and spleen correlated well with HVPG ( R = 0.44, p = 0.02, and R = 0.57, p = 0.002, respectively) [13]. However, the accessibility of this technique due to hardware availability and cost, and the feasibility of MRE in some patients, can limit its clinical translation.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging

Palaniyappan

Cox

Bradley

et al. 2016

Journal of Hepatology

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“…This encouraging result would require further confirmation (24). LSM assessed by other methods, such as Acoustic Radiation Force Impulse, shear-wave elastography, and magnetic resonance elastography, has shown promising results but available data is still scarce (25,26).…”

Section: Non-invasive Methods For the Detection Of Vntmentioning

confidence: 93%