Assessment of postoperative complications in craniopharyngioma patients: An approach based on the heterogeneous tumor-hypothalamus relationship

This study investigates the presence of a hollow recess at the midline undersurface of tumors primarily localized within the third ventricle (3V). This structure was originally identified by magnetic resonance imaging (MRI) of 6 3V craniopharyngiomas (CPs) from our series and was then methodically scrutinized in autopsy studies (n = 1091) and MRI scans (n = 5558) of CPs and in 1251 3V tumors reported in the medical literature from 1839 to 2021. A recess at the tumor base was identified in 110 CPs, 95 with a verified papillary histology (papillary craniopharyngioma [PCP]) and 15 with typical gross appearance of PCP. Topographically, 90 tumors were strictly within the 3V (82%); 20 developed at the infundibulo-tuberal region of the 3V floor (18%). Morphologically, 2 main types of recess were identified: (i) a long, narrow recess with either a duct-like or a tubular shape that reached the central region of the CP (n = 47, 42.5%); and (ii) a short recess extending only a few millimeters into the lesion, either with a duct-like or a shallow cleft-like morphology (n = 63, 57.5%). Thus, the presence of a basal recess represents a pathological hallmark of a subpopulation of 3V PCPs. The presumed nature and diagnostic significance of this novel finding is comprehensively addressed.

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Basal Recess in Third Ventricle Tumors

Pascual¹,

Prieto²,

Carrasco³

et al. 2022

Journal of Neuropathology &Amp; Experimental Neurology

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Assessment of postoperative complications in craniopharyngioma patients: An approach based on the heterogeneous tumor-hypothalamus relationship

Cited by 1 publication

References 7 publications

Basal Recess in Third Ventricle Tumors

Basal Recess in Third Ventricle Tumors

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