Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma

Shen, Yi; Xu, Haoyue; Li, Lingyu; Lu, Yao; Zhang, Min; Huang, Xin; Tang, Xiaofei

doi:10.2147/cmar.s319048

Cited by 5 publications

(15 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although its role in diseases such as inflammation and cancer has been gradually elucidated as research has deepened, there have been a few studies exploring the expression and mechanism of Prdx1 in OSCC. In OSCC, increased levels of Prdx1 have been observed in previous studies [7,12], while contrasting findings have also been reported [27]. Prdx1 is elevated in oral leukoplakia and dysplastic oral keratinocytes and is crucial for the transformation of precancerous lesions into malignant cancer [28,29].…”

Section: Discussionmentioning

confidence: 86%

“…The peroxiredoxin (Prdx) family, another vital oxidative defense system, that serves as the direct substrate of Trx, remains lacking in research. Prdx1 is the most studied among the Prdx family members, whose abnormal expression has been observed in various tumors and precancerous lesions, including OSCC [6,7], esophageal cancer [8], and others [8]. Cancer patients with stronger Prdx1 expression often suffer from worse outcomes [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Cancer patients with stronger Prdx1 expression often suffer from worse outcomes [9,10]. In a study involving 68 OSCC patients, Prdx1 expression correlated with clinical stage, lymphatic metastasis, and pathological grade, indicating its potential as a prognostic biomarker for survival [7]. Although Prdx1 has been implicated in cancer cell proliferation, metastasis, invasion, angiogenesis, and other processes [8,11,12], the underlying molecular mechanisms remain incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival

Ye,

Liu,

Liu

et al. 2023

Cell Death Discov.

View full text Add to dashboard Cite

Peroxiredoxin 1 (Prdx1), a vital antioxidant enzyme, has been proven to play an important role in the occurrence and development of cancers, but its effects on oral squamous cell carcinoma (OSCC) remain unclear. Here, we performed bioinformatics analysis and immunohistochemical (IHC) staining to confirm that Prdx1 was higher in OSCC tissues than in normal tissues. Consistently, RT-PCR and Western blot showed elevated Prdx1 expression in OSCC cell lines compared to human oral keratinocytes (HOK), which could be knockdown by small interfering RNA (siRNA) and Lentiviral vector delivery of short hairpin RNA (shRNA). Prdx1 silencing significantly blocked OSCC cell proliferation and metastasis, as evidenced by the CCK8, colony formation, in vivo tumorigenesis experiment, wound healing, transwell assays, and changes in migration-related factors. siPrdx1 transfection increased intracellular reactive oxygen species (ROS) levels and provoked pyroptosis, proved by the upregulation of pyroptotic factors and LDH release. Prdx1 silencing ROS-independently blocked autophagy. Mature autophagosome failed to form in the siPrdx1 group. Up-regulated autophagy limited pyroptosis triggered by Prdx1 deficiency, and down-regulated pyroptosis partly reversed siPrdx1-induced autophagy defect. Collectively, Prdx1 regulated pyroptosis in a ROS-dependent way and modulated autophagy in a ROS-independent way, involving the crosstalk between pyroptosis and autophagy.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival

Ye,

Liu,

Liu

et al. 2023

Cell Death Discov.

View full text Add to dashboard Cite

show abstract

“…Some studies indicate a close relationship between PRDX1 and other gastrointestinal cancers such as pancreatic cancer 74 , cholangiocarcinoma 75 , and oral cancer 76 . In pancreatic cancer, there is a significant elevation in PRDX1 expression levels, making it a viable therapeutic target.…”

Section: Resultsmentioning

confidence: 99%

“…In cholangiocarcinoma, PRDX1 expression also significantly increases, influencing the occurrence and development of cholangiocarcinoma by regulating SNAT1 expression 75 . In oral cancer, PRDX1 is highly expressed and is significantly correlated with tumor staging, lymph node metastasis, and pathological grading, making it a promising biomarker for predicting lymph node metastasis and prognosis in oral cancer patients 76 . However, these gastrointestinal cancers have a relatively low incidence rate.…”

Section: Resultsmentioning

confidence: 99%

Expression And Prognostic Role of PRDX1 In Gastrointestinal Cancers

Zhang,

Zhou,

Liu

et al. 2023

J. Cancer

View full text Add to dashboard Cite

Esophageal, gastric, liver, and colorectal cancers represent four prevalent gastrointestinal cancers that pose substantial threats to global health due to their high morbidity and mortality rates. Peroxiredoxin 1 (PRDX1), a significant component of the PRDXs family, primarily functions to counteract the peroxides produced by metabolic activities in the body, thereby maintaining the dynamic equilibrium of peroxides in vivo . Intriguingly, PRDX1 expression correlates strongly with cancer's onset, progression, and prognosis. This study mainly applied bioinformatics methods to analyze PRDX1's expression, diagnosis, and prognosis in gastrointestinal cancers and to summarize current research advancements. Evidence from the bioinformatics database suggested that the high expression of PRDX1 was a prominent characteristic of these four gastrointestinal cancers, with this observation reaching statistical significance. The high expression of PRDX1 in gastrointestinal cancer cells also confirms this result. Notably, the primary alteration in PRDX1 within these cancers is the presence of genetic mutations. PRDX1 demonstrated the highest diagnostic efficacy for colorectal cancer. Nevertheless, elevated PRDX1 levels only significantly diminished the survival time of liver cancer patients, exerting no statistically significant impact on the survival duration of patients afflicted by the other three types of gastrointestinal cancers. Recent research has indicated variability in PRDX1 expression across different cancer types, with high expression being predominantly observed in these four gastrointestinal cancers and, in most instances, unfavorable prognosis. These findings broadly align with the results derived from bioinformatics. This research underscores the high expression of PRDX1 in gastrointestinal cancers, its relevance to the diagnosis and prognosis monitoring of these cancers, and its potential to guide clinical treatment for these cancers.

show abstract

The interaction of PRDX1 with Cofilin promotes oral squamous cell carcinoma metastasis

Shen,

You,

et al. 2024

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Peroxiredoxin 1 (PRDX1) is an important member of the peroxiredoxin family (PRDX) and is upregulated in a variety of tumors. Previous studies have found that high PRDX1 expression is closely related to the metastasis of oral squamous cell carcinoma (OSCC), but the specific molecular mechanism is elusive. To elucidate the role of PRDX1 in the metastasis process of OSCC, we evaluated the expression of PRDX1 in OSCC clinical specimens and its impact on the prognosis of OSCC patients. Then, the effect of PRDX1 on OSCC metastasis and cytoskeletal reconstruction was explored in vitro and in nude mouse tongue cancer models, and the molecular mechanisms were also investigated. PRDX1 can directly interact with the actin‐binding protein Cofilin, inhibiting the phosphorylation of its Ser3 site, accelerating the depolymerization and turnover of actin, promoting OSCC cell movement, and aggravating the invasion and metastasis of OSCC. In clinical samples and mouse tongue cancer models, PRDX1 also increased lymph node metastasis of OSCC and was negatively correlated with the phosphorylation of Cofilin; PRDX1 also reduced the overall survival rate of OSCC patients. In summary, our study identified that PRDX1 may be a potential therapeutic target to inhibit OSCC metastasis.

show abstract

Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma

Cited by 5 publications

References 53 publications

Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival

Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival

Expression And Prognostic Role of PRDX1 In Gastrointestinal Cancers

The interaction of PRDX1 with Cofilin promotes oral squamous cell carcinoma metastasis

Contact Info

Product

Resources

About