Coronavirus Disease 2019 (COVID-19) has been declared a pandemic because of its worldwide spread. The COVID-19 pandemic does not only impact public health but also the operations of businesses and workers’ safety in their workplace. The objectives of this study were to provide a broad perspective of COVID-19 prevention and control implementation in industries, investigate barriers and challenges as well as drivers in implementing COVID-19 prevention and control, and provide key recommendations to the policy makers regarding COVID-19 prevention and control in industries. This study was conducted through online interviews with selected organizations in various industries which were selected by the granting body, including agriculture and animal husbandry; construction; manufacturing; and logistic and goods transportation. It also involved policy makers from government agencies including the Ministry of Manpower, Ministry of Health, Indonesian Safety and Health Council, International Labor Organization, and Indonesian COVID-19 Task Force. The participants of this study were chosen using convenience sampling. The findings of this study indicate that health protocols are implemented to varying degrees in companies, both within and across the sectors, and that drivers to comply with the Health Protocols include compliance, business continuity, and top management commitment. The significant barriers and challenges include a perceived lack of clear direction from the government, rapid changes in directives’, poor worker awareness, and limited organizational resources. The key recommendations to the policy maker include harmonization of the guidelines and legislation, additional schemes to provide funding in the COVID-19 prevention and control implementation, as well as facilitate the ongoing education of the general working public.