Assessment of premature coronary atherosclerosis in patients with systemic lupus erythematosus disease

Heshmat, Tarek S.; Khalil, Noha M.; Elhamid, Huda Abd; Labib, Safa; Mahfouz, Mamdouh

doi:10.1016/j.ejr.2015.04.001

Cited by 13 publications

(4 citation statements)

References 23 publications

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“…Compared to healthy individuals, circulating cholesterol levels were found either not altered 4 , 47 , 48 , 49 , 50 , 51 or decreased 3 , 42 , 43 , 44 in patients with SLE and were not associated with the presence of coronary calcium in SLE, although cholesterol concentration was positively associated with CAC progression in SLE patients during a 2-year follow-up. 52 While circulating lipid concentrations related to apoB-containing lipoproteins (LDL-C and TG) increased with CAC scores, they failed to act as independent predictors of the presence of coronary calcium in our cohort of patients with SLE.…”

Section: Discussionmentioning

confidence: 78%

Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus

Urbain,

Ponnaiah,

Ichou

et al. 2023

eBioMedicine

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Section: Discussionmentioning

confidence: 78%

Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus

Urbain,

Ponnaiah,

Ichou

et al. 2023

eBioMedicine

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“…As a result of increased atherogenesis and arterial hypertension in patients with SLE, the lesions of the coronary and cerebral arteries are observed [3,56,107,154,161]. This can lead to coronary artery disease, including at a young age (myocardial infarction, angina), as well as stroke, transient ischemic attack, lower extremities peripheral vessels damage, and so on.…”

Section: Methodsmentioning

confidence: 99%

Untitled

2021

Lʹviv. klin. visn.

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Оригінальні дослідженняdrug treatment in patients of the control group there was a significant clinical and functional improvement, though sinus tachycardia, ventricular extrasystole of high grades and supraventricular extrasystole remained resistant to treatment. There was also a pronounced endothelial vascular dysfunction, which in the process of standard treatment in patients of the control group did not reach the level of healthy individuals (p < 0.05).Conclusions. In patients with acute MI with comorbid MS, who underwent balloon angioplasty and stenting of the infarct-dependent coronary artery, a pronounced vascular endothelial dysfunction and electrical instability is observed, accompanied by reperfusion arrhythmias and arrhythmias. The use of arginine-carnitine mixture as upstream therapy helped to restore endothelial function and showed a pronounced antiarrhythmic effect, which significantly reduced the incidence and severity of complications of acute MI such as reperfusion arrhythmias.

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“…SLE characterizes by microvascular inflammation with the development of autoantibodies, particularly against nuclear components [2]. Autoantibody and autoreactive T-cell presentation occur against several ubiquitous nuclear antigens, including chromatin particles and ribonucleoproteins, unleashing systemic autoimmunity and organ damage through additional mechanisms of inflammation and tissue remodeling [3].…”

Section: Introductionmentioning

confidence: 99%

Title The Role of the Oxidative State and Innate Immunity Mediated by TLR7 and TLR9 in Lupus Nephritis

Miranda-Díaz,

Echavarría,

Cardona-Muñoz

et al. 2023

Preprint

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Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) and is considered one of the leading causes of mortality. Multiple immunological pathways are involved in the pathogenesis of SLE, which makes it imperative to deepen our knowledge about this disease's immunopathological complexity and explore new therapeutic targets. Since an altered redox state contributes to immune system dysregulation, this document briefly addresses the role of oxidative stress (OS), oxidative DNA damage, antioxidant enzymes, mitochondrial function, and mitophagy in SLE and LN. Although adaptive immunity's participation in the development of autoimmunity is undeniable, increasing data emphasize the importance of innate immunity elements, particularly the Toll-like receptors (TLRs) that recognize nucleic acid ligands, in inflammatory and autoimmune diseases. Here, we discuss the intriguing role of TLR7 and TLR9 in developing SLE and LN. Also included are the essential characteristics of conventional treatments and some other novel and little-explored alternatives that offer options to improve renal function in LN.

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Assessment of premature coronary atherosclerosis in patients with systemic lupus erythematosus disease

Cited by 13 publications

References 23 publications

Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus

Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus

Untitled

Title The Role of the Oxidative State and Innate Immunity Mediated by TLR7 and TLR9 in Lupus Nephritis

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