Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers

Abstract

Background Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis. Research aims To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children. Methods Thirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Mothers’ breast milk Preptin were also measured. Results Significantly lower serum Preptin ( p < 0.001) in rachitic children with a significant negative correlation between serum Preptin and alkaline phosphatase ( P < 0.0001). Lower breastmilk Preptin levels in mothers of rachitic children ( P < 0.001) with a negative correlation between breastmilk Preptin and both maternal weight and BMI( P < 0.01& P < 0.02). Mothers’ milk Preptin is positively correlated with serum Preptin and calcium in non-rachitic children(P < 0.001&0.04), but negatively correlated with their mothers’ age ( P < 0.01). Conclusion Preptin may play a role in the etiology of rickets in children. Further studies are recommended to evaluate Preptin role in treatment of rickets in children.

Insulin‐like growth factor‐II and bioactive proteins containing a part of the E‐domain of pro‐insulin‐like growth factor‐II

“…Serum preptin and breast milk preptin were found to be lower in rachitic children and their mothers, respectively, when compared to non-rachitic subjects. 113 Serum preptin levels are decreased in both men and women with osteoporosis and positively correlate with bone mass density. 114,115 It is therefore likely that a lower activity of preptin is involved in the pathogenesis of osteoporosis, affecting bone formation rather than bone resorption.…”

Preptin: A New Bone Metabolic Parameter?

“…A significant positive correlation was found between preptin and lumbar spine and neck BMD, respectively, after adjustment for estradiol in both groups. Preptin was also negatively correlated with age in the whole group [ 76 , 79 , 80 ]. A recent article published in 2021 was the first to investigate the relationship between preptin and bone metabolism in hemodialysis patients [ 77 ] ( Table 2 ).…”

“…Bebars et al [ 79 ] found lower serum preptin levels in rachitic children compared to healthy controls. Preptin was inversely associated with ALP in rachitic patients, suggesting preptin may also mirror the severity of the disease, similar to ALP ( Table 2 ) [ 79 ].…”

“…Bebars et al [ 79 ] found lower serum preptin levels in rachitic children compared to healthy controls. Preptin was inversely associated with ALP in rachitic patients, suggesting preptin may also mirror the severity of the disease, similar to ALP ( Table 2 ) [ 79 ]. As rickets is characterized by increased bone turnover and low BMD [ 80 ], the evidence of accompanying low preptin levels agrees with previous studies reporting decreased preptin in conditions associated with low bone mass.…”