Assessment of proliferating cell nuclear antigen in nasopharyngeal carcinoma tissue and its relation to clinical findings

Chan, Anthony Tak-cheung; Ho, Stephen; Teo, Peter M.L.; Tjong, Jessica; Choi, Jong Myung; Lee, W.Y.; Chang, Alexander R.; Kwan, W. H.; Leung, WK; Johnson, P. J.

doi:10.1016/s0964-1955(96)00029-2

Cited by 8 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PCNA LI varies widely in our series, ranging from 6.5% to 92.9% (mean 53.4%). The result is consistent with the other studies [8,9,15,16]. Chan et al [8] reported that high PCNA LI was associated with a poorer disease-free survival, but PCNA LI has nothing to do with Ho's clinical staging or time required to achieve complete remission.…”

Section: Discussionsupporting

confidence: 90%

“…The result is consistent with the other studies [8,9,15,16]. Chan et al [8] reported that high PCNA LI was associated with a poorer disease-free survival, but PCNA LI has nothing to do with Ho's clinical staging or time required to achieve complete remission. Tsai et al [10] reported that high PCNA LI was probably related to local relapse, but Genç et al [9] claimed that the PCNA LI was not correlated with prognosis.…”

Section: Discussionsupporting

confidence: 90%

“…Many studies have demonstrated the association of high expression rate of PCNA with poor prognosis in many solid tumors [5Á7], but the role of PCNA in NPC is still controversial. Some studies have proposed the existence of negative correlation between high expression of PCNA and survival time [8]; but others found no correlation [9,10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The prognostic value of proliferating cell nuclear antigen (PCNA) and p53 protein expression in patients with advanced nasopharyngeal carcinoma

Wang

Chai

Kuo

et al. 2006

Acta Oto-Laryngologica

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

The prognostic value of proliferating cell nuclear antigen (PCNA) and p53 protein expression in patients with advanced nasopharyngeal carcinoma

Wang

Chai

Kuo

et al. 2006

Acta Oto-Laryngologica

View full text Add to dashboard Cite

show abstract

“…Its level reaches a maximum in the S phase, decreases during the M phase and it can not be detected in quiescent cells (Hall et al 1990;Bolton et al 1992). The frequency of PCNA-positive nuclei is of diagnostic importance, because its high expression proved to be correlated with a bad prognosis in a large number of tumour types, for example carcinomas of oral cavity (Staibano et al 1998), nasopharynx (Chan et al 1997), oesophagus (Kinugasa et al 1996), gaster (Isozaki et al 1998), colon and rectum (Nakae et al 1998), liver (Tannapfel et al 1999), bile duct (Suto et al 1997), larynx (Dobro et al 1998), lung (Lavezzi et al 1999, breast (Horita et al 2001), ovary (Thomas et al 1995), endometrium (Garzetti et al 1996), kidney (Sejima and Miyagawa 1999), bladder (Chen et al 1997) and thyroid gland (Omura et al 1997). The frequency of PCNA-positive nuclei is of diagnostic importance, because its high expression proved to be correlated with a bad prognosis in a large number of tumour types, for example carcinomas of oral cavity (Staibano et al 1998), nasopharynx (Chan et al 1997), oesophagus (Kinugasa et al 1996), gaster (Isozaki et al 1998), colon and rectum (Nakae et al 1998), liver (Tannapfel et al 1999), bile duct (Suto et al 1997), larynx (Dobro et al 1998), lung (Lavezzi et al 1999, breast (Horita et al 2001), ovary (Thomas et al 1995), endometrium (Garzetti et al 1996), kidney (Sejima and Miyagawa 1999), bladder (Chen et al 1997) and thyroid gland (Omura et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Characterisation of the progression of azaserine-induced rat pancreatic adenocarcinoma by proliferative cell nuclear antigen, basement membrane laminin and trypsinogen immunohistochemistry

Nagy

Pálfia

Réz

2003

Histochem Cell Biol

View full text Add to dashboard Cite

The progression of azaserine-induced rat pancreatic adenocarcinoma (AC) was characterised using quantitative and semiquantitative immunohistochemistry for proliferating cell nuclear antigen (PCNA), basement membrane laminin (BML) and trypsinogen (TG). Samples were taken 5-20 months after initiation. High PCNAlabelling indices (PCNA LIs) were measured 5 months after the induction of atypical acinar cell nodules (AACNs), which decreased later and stagnated until a further decline in the month 10 adenomas. Then a second premalignant proliferative wave was observed (month 13) within the adenoma stage. Later, in month 20 differentiated ACs PCNA LIs fell to the host tissue level but were found highest in the month 20 anaplastic ACs indicating a switch to malignant proliferation. Month 20 invasive ACs showed a number of separate proliferative foci. In early AACNs, BML decreased and remained low till the local maximum in the month 13 adenoma. Invasive ACs did not express BML. Month 5 AACN and differentiated AC were TG deficient but anaplastic AC regained its TG expression. However invasive AC was again TG negative. These results are discussed in combination with our previous data on progressional changes of autophagic capacity and microvessel densities.

show abstract

Nasopharyngeal Carcinoma

O’Sullivan¹,

Chong²

2014

TNM Online

View full text Add to dashboard Cite

Nasopharyngeal carcinoma (NPC) is unusual in several ways. Its epidemiology, associated with ethnicity, genetic predisposition, viral, and environmental dietary exposure, is unique in itself. In addition, the predilection for certain geographic areas, with relative sparing of adjacent regions is noteworthy. Unjustly perhaps, NPC poses a formidable public health hazard to countries that are relatively compromised in their ability to provide the technical diagnostic and therapeutic approaches considered to be necessary for optimal management today. However, what sets it apart from most diseases is the anatomic challenge it presents to the oncology team because of the proximity of the nasopharynx to critical anatomic structures and the high predilection for distant metastasis once the primary and regional lymph‐node areas are extensively involved, which is all too frequent. In this chapter we discuss prognostic factors of importance in the management of NPC using the classification proposed earlier in this book. Factors will be considered by whether they relate to the disease itself, the patient (or host ), or the environment which influences the opportunity for optimal treatment and diagnosis. The classification may not always apply since, in the case of NPC, there may be overlap among factors and arbitrary placement of factors may be necessary. We will also attempt to categorize the available evidence into factors which are essential to our ability to treat the disease ( essential factors), those which add valuable information about the disease but do not affect treatment decisions ( additional factors), and finally those that are being described and may provide important understanding of disease behavior and therapeutic approaches in future years. In the interest of relevance to the treatment of the disease, and for brevity, the discussion of the final group of factors (those termed new and promising ), will be restricted to experience of patient outcome. Therefore, preclinical studies will not receive attention. Special attention to the classification of stage of disease will be given. This is because for NPC anatomic features are so important that a relevant and reproducible system of classification merits attention above other prognostic factors. In fact, few diseases received the same level of attention in the preparation of the 5th edition (TNM) stage classification of the International Union Against Cancer (UICC) and the American Joint Committee on Cancer (AJCC). A major revision of the NPC stage was accomplished by a substantial collaborative consultation among radiation oncologists in Southeast Asia, with support from diagnostic radiologists, pathologists, and surgeons there and elsewhere.

show abstract

Assessment of proliferating cell nuclear antigen in nasopharyngeal carcinoma tissue and its relation to clinical findings

Cited by 8 publications

References 29 publications

The prognostic value of proliferating cell nuclear antigen (PCNA) and p53 protein expression in patients with advanced nasopharyngeal carcinoma

The prognostic value of proliferating cell nuclear antigen (PCNA) and p53 protein expression in patients with advanced nasopharyngeal carcinoma

Characterisation of the progression of azaserine-induced rat pancreatic adenocarcinoma by proliferative cell nuclear antigen, basement membrane laminin and trypsinogen immunohistochemistry

Nasopharyngeal Carcinoma

Contact Info

Product

Resources

About