Assessment of Protective Effects of Methylprednisolone and Pheniramine Maleate on Reperfusion Injury in Kidney After Distant Organ Ischemia: A Rat Model

Bayrak, Serdar; Yurekli, Ismail; Gokalp, Orhan; Kıray, Müge; Bademci, Mehmet Şenel; Özçem, Barçın; Besir, Yuksel; Yilik, Levent; Kestelli, Mert; Gürbüz, Ali

doi:10.1016/j.avsg.2012.01.006

Cited by 13 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results indicating a protective effect in various organs in the former studies on zofenopril and PM encouraged us to think that they may have a renal protective effect by hydronephrosis due to ureter obstruction, which is very common in urological practice. Nosalova and Bayrak demonstrated the I/R damage preventive effect of pheniramine on the gastrointestinal and renal system respectively [7,18]. Mak et al detected that zofenopril has a protective effect against lipid peroxidation caused by the free radicals on endothelial cells [19].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

et al. 2021

View full text Add to dashboard Cite

Introduction: Obstruction of the ureter may occur due to congenital, iatrogenic or other reasons. This can cause hydronephrosis in the early stage and can lead to cellular inflammation, necrosis and atrophy in the kidney tissue. The aim of this paper is to evaluate the protective effect of pheniramine maleate (PM) and zofenopril on renal damage caused by hydronephrosis due to unilateral partial ureter obstruction. Material and methods: Twenty-four female Sprague Dawley rats were divided into 4 groups. Group 1: sham group, group 2: partial unilateral ureteral obstruction (PUUO) group, group 3: PUUO + PM group, group 4: PUUO + zofenopril group. Paraoxonase (PON), total antioxidant status (TAS) and total oxidant status (TOS) of tissue and blood samples were measured and calculated. Tissue samples were evaluated histopathologically. Results: An increase in tissue TAS and a decrease in tissue TOS and OSI levels were detected in groups 3 and 4 compared to group 2 (both: p < 0.01). Tissue PON levels showed an increase in groups 3 and 4 compared to groups 1 and 2 (both: p < 0.01). Histopathological evaluation showed a decrease in interstitial inflammation and congestion in groups 3 and 4 compared to the control group (p < 0.001). The decrease was observed to be more significant in group 4 compared to group 3 (p < 0.01). Conclusion: In our experimental study, we observed that PM and zofenopril reduce the oxidation and tissue damage caused by unilateral partial obstruc tion.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We demonstrated that brains of the rats of the study and sham groups were subjected to reperfusion injury when compared with that of the control group. It was previously reported in several studies that glucocorticoids inhibited lipid peroxidation and production of free radicals; thus reducing I/R injury in many organs [3,5–7,15,21,22]. Some authors argued that these effects appeared in high doses [6,15], whereas some authors argued that these effects appeared even in low doses [8,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Pn was shown to have protective effects against renal reperfusion injury at a relatively lower dose (30 mg/kg) [22]. In another study, Pn was shown to be effective in renal reperfusion injury at a dose of 50 mg/kg after distant ischemia of an extremity [3]. Yeginsu et al studied the effects of different doses of Pn on reperfusion injury of lungs: 15 mg/kg, 50 mg/kg and 150 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…The same study stated that Pn showed this effect as being a direct radical scavenger or through interaction with regulatory cellular mechanisms [17]. In the only study with use of pheniramine conducted apart from the gastrointestinal system, Bayrak et al showed that Pn was effective in renal I/R injury after distant organ ischemia [3]. In our study, we observed that Ph was more beneficial in preventing cerebral I/R injury than Mp administered at a relatively smaller dose.…”

Section: Discussionmentioning

confidence: 99%

“…The most important location where they show their anti-inflammatory effects is at the level of transcription factor, specifically NF-kB. Activation of NF-kB is stimulated by histamine and inhibited by antihistaminics [3,9,10]. As with the other H 1 -antihistaminics, Ph shows its effect on I/R injury by inhibiting release of some specific mediators of inflammation, which is a significant factor in I/R pathophysiology [3,11–13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of pheniramine maleate on reperfusion injury in brain tissue

Yurekli

Gokalp

Kıray

et al. 2013

Med Sci Monit Basic Res

View full text Add to dashboard Cite

BackgroundThe aim of this study was to investigate the protective effects of methylprednisolone (Pn), which is a potent anti-inflammatory agent, and pheniramine maleate (Ph), which is an antihistaminic with some anti-inflammatory effects, on reperfusion injury in brain developing after ischemia of the left lower extremity of rats.Material/MethodsTwenty-eight randomly selected male Sprague-Dawley rats were divided into 4 groups: Group 1 was the control group, Group 2 was the sham group (I/R), Rats in Group 3 were subjected to I/R and given Ph, and rats in Group 4 were subjected to I/R and given Pn. A tourniquet was applied at the level of left groin region of subjects in the I/R group after induction of anesthesia. One h of ischemia was performed with no drug administration. In the Ph group, half of a total dose of 10 mg/kg Ph was administered intraperitoneally before ischemia and the remaining half before reperfusion. In the Pn group, subjects received a single dose of 50 mg/kg Pn intraperitoneally at the 30th min of ischemia. Brains of all subjects were removed after 24 h for examination.ResultsMalondialdehyde (MDA) levels of the prefrontal cortex were significantly lower in the Ph group than in the I/R group (p<0.05). Superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities were found to be significantly higher in the Ph group than in the I/R group (p<0.05). Histological examination demonstrated that Ph had protective effects against I/R injury developing in the brain tissue.ConclusionsPh has a protective effect against ischemia/reperfusion injury created experimentally in rat brains.

show abstract

Postoperative Considerations of Cardiopulmonary Bypass in Adult Cardiac Surgery

Foroughi

2013

Postoperative Critical Care for Cardiac Surgical Patients

View full text Add to dashboard Cite

Assessment of Protective Effects of Methylprednisolone and Pheniramine Maleate on Reperfusion Injury in Kidney After Distant Organ Ischemia: A Rat Model

Cited by 13 publications

References 15 publications

Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

Effect of pheniramine maleate on reperfusion injury in brain tissue

Postoperative Considerations of Cardiopulmonary Bypass in Adult Cardiac Surgery

Contact Info

Product

Resources

About