Assessment of psychological tension after premedication by measurement of salivary chromogranin A

Obara, Shinju; Iwama, Hiroshi

doi:10.1016/j.jclinane.2005.08.001

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…Basal CgA levels were unrelated to other manifestations of sympathetic nervous system activity. Moreover, others have reported that the measurement of salivary CgA may not be a good parameter to evaluate the activity of the sympathetic nervous system (Obara and Iwama 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Such stressors include psychosomatic stress (Nakane et al 1998), computer operation psychological stress (Nakane et al 2002), academic assessment stress (Ng et al 2003), and psychological tension stress before surgery or anesthesia (Obara and Iwama 2005). Ng et al (2003), however, reported that no significant differences were noted between the pre-and post-test saliva samples for CgA levels with academic assessment stress among dental undergraduates.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, interest has developed in measuring salivary chromogranin-A (CgA) concentration as a method of evaluating psychological stress (mental workload or psychological tension) (Nakane et al 1998(Nakane et al , 2002Ng et al 2003;Noto et al 2005;Obara and Iwama 2005). Others have reported that human saliva CgA measurement is clinically promising as a psychological stress marker, and they also reported that CgA in humans is produced by the submandibular glands and secreted into saliva (Saruta et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Salivary chromogranin-A as a marker of psychological stress during a cognitive test battery in humans

Kanamaru¹,

Kikukawa²,

Shimamura

2006

Stress

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The purpose of the present study was to evaluate the salivary Chromogranin-A (CgA) response to the psychological stress induced by a cognitive test battery. The subjects were 14 healthy volunteers administered the cognitive test battery CogScreen Aeromedical Edition (CogScreen-AE). CogScreen-AE is a test of reaction time and fundamental cognitive ability in the assessment of aeroplane pilots. The subjects were given five batteries of the test (1st approximately 5th) on separate days with 2 week intervals. Saliva samples were collected at 20 min before the test (BASE), immediately before the test (PRE), in the middle of the test (MID), and 5 min after the test (POS) for each subject. The concentration of CgA was determined by enzyme-linked immunosorbent assay. ANOVA revealed a significant by time interaction (BASE, PRE, MID and POS) without a significant effect of battery interaction (1st, 2nd, 3rd, 4th and 5th). The CgA concentration increased at PRE (2.46 +/- 0.24 pmol.mg protein- 1) from BASE (1.19 +/- 0.10 pmol.mg protein- 1). CgA level remained increased in the MID (2.90 +/- 0.26 pmol.mg protein- 1) and remained high in the POS samples (2.81 +/- 0.23 pmol.mg protein- 1). Salivary CgA remained at basal levels during a control study over the same time course without exposure to CogScreen-AE. The changes in salivary CgA secretion as a result of exposure to a cognitive task may indicate psychological stress in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary chromogranin-A as a marker of psychological stress during a cognitive test battery in humans

Kanamaru¹,

Kikukawa²,

Shimamura

2006

Stress

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“…Two main body systems are involved in the stress response: the sympathetic adrenomedullary (SAM) system and the hypothalamus-pituitary-adrenal axis (HPA-axis). Recently, there has been increasing interest in measuring salivary chromogranin-A (CgA) concentrations as an indicator of psychological stress levels (22,33,34,(36)(37)(38). Human CgA is produced by the submandibular glands, and secreted into the saliva (48); it can thus be measured non-invasively with relatively little stress (26).…”

Section: Methodsmentioning

confidence: 99%

Oral administration of Cimicifuga racemosa extract attenuates psychological and physiological stress responses

et al. 2012

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“…Recently, several studies have examined the use of salivary CgA as a psychological stress marker (Obata, 2005;Toda, Morimoto, Nagasawa & Kitamura, 2006). Nakane et al (1998) determined that salivary CgA can be a sensitive and substantive index of psychosomatic stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of color images on stress reduction: Using images as mood stimulants

Saito

Tada

2007

Japan Journal Nursing Sci

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Aim: The aim of this study was to determine whether color images can be used as mood stimulants. Methods: Color photographs of natural scenery were shown to an experimental group (n = 10), while the same images in black and white were shown to a control group (n = 10). The test subjects were healthy, adult volunteers who were exposed to psychosomatic stress in mental work rather than physical labor. To determine the effects of the color images, the levels of salivary chromogranin A (CgA) and salivary cortisol were measured as biochemical parameters, and the mood adjective score was examined as an emotional parameter before and after showing the subjects the images. The data obtained were statistically compared. Results: In the experimental group, the salivary CgA level decreased significantly after viewing the color images. In the control group, the salivary cortisol level increased significantly after viewing the black and white images. The changes in the salivary CgA and salivary cortisol values in the experimental group were significantly different from the corresponding changes in the control group. In the experimental group, after viewing the color images, the negative mean mood score decreased, and four subjects were shown to have had their mood changed to a more parasympathetically dominant state, as assessed by alterations in three or more of four stress parameters (CgA, cortisol, Multiple Mood Scale negative and positive factors). Conclusion: Color images might potentially change the mood of a viewer to a more parasympathetically dominant state.

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Assessment of psychological tension after premedication by measurement of salivary chromogranin A

Cited by 18 publications

References 20 publications

Salivary chromogranin-A as a marker of psychological stress during a cognitive test battery in humans

Salivary chromogranin-A as a marker of psychological stress during a cognitive test battery in humans

Oral administration of Cimicifuga racemosa extract attenuates psychological and physiological stress responses

Effects of color images on stress reduction: Using images as mood stimulants

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