Assessment of pulmonary hypertension by CT and MR imaging

Ley, Sebastian; Kreitner, Karl‐Friedrich; Fink, Christian; Heußel, Claus Peter; Borst, Mathias M.; Kauczor, Hans‐Ulrich

doi:10.1007/s00330-003-2208-x

Cited by 69 publications

(30 citation statements)

References 68 publications

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“…Recent technical advances, such as the development of multi-slice and multidetector-row CT, make it possible to measure dynamic heart images in an acceptable period of time [77]. Although its main role in phenotyping pulmonary hypertension is well established [78], the role of CT in the longitudinal assessment of PAH is largely unexplored. However, it is reasonable to expect similar results to those of MRI as regards right ventricular structure and function with the now widely available 64-slice ECG-gated scanners.…”

Section: Computed Tomographic Scanningmentioning

confidence: 99%

End-points and clinical trial design in pulmonary arterial hypertension: have we made progress?

Peacock¹,

Naeije²,

Galiè³

et al. 2009

Eur Respir J

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There is enormous interest in the treatment of pulmonary arterial hypertension (PAH), so it is appropriate to consider the design of trials of new therapies and the end-points to be measured when trying to decide whether or not a therapy is effective.In May 2003, the first meeting devoted solely to the discussion of end-points and trial design in PAH was held in Gleneagles, UK. At that time, most of the randomised controlled trials in PAH had used 6-min walking distance and/or resting haemodynamics as their primary end-points.The present article considers the progress that has been made since 2003. It deals with aspects of clinical trial design (such as noninferiority, superiority and withdrawal trials), considers endpoints used in previous and current studies (such as 6-min walking distance, time to clinical worsening, haemodynamics, imaging and plasma brain natriuretic peptide), and considers what end-points might be used in the future.The second end-points meeting was held in Turnberry, UK, in June 2007. It had a similar format to the first meeting. Much of what is presented here is a summary of the workshops from that meeting. An attempt has been made to both summarise the current state of end-points and trial design and suggest new ways in which they could be improved. The present article forms one of a series being published in the European Respiratory Journal on pulmonary hypertension.

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Section: Computed Tomographic Scanningmentioning

confidence: 99%

End-points and clinical trial design in pulmonary arterial hypertension: have we made progress?

Peacock¹,

Naeije²,

Galiè³

et al. 2009

Eur Respir J

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“…One group of authors (51) compared perfusion changes detected on MRI with those detected on The method comprises excellent characteristics, such as low operator dependence, high accuracy, and good reproducibility. (44) The MRI technique can be used for the assessment of the lung parenchyma and pulmonary circulation, as well as for the dynamic analysis of the heart. In the assessment of the lung parenchyma, MRI faces some challenges: low proton density of the lung parenchyma, resulting in a low signal/ noise ratio; signal loss during physiological motion of the intrathoracic organs; and the combination of air and soft tissues, which increases its susceptibility to artifacts.…”

Section: Mrimentioning

confidence: 99%

O papel dos exames de imagem na avaliação da circulação pulmonar

et al. 2011

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O conhecimento sobre a estrutura e a função da circulação pulmonar evoluiu sensivelmente nas últimas décadas. A utilização de exames de imagem não invasivos para a avaliação da anatomia e da função dos vasos pulmonares e do coração ganhou ainda mais importância com o advento de tratamentos até então indisponíveis. Além do auxílio para o diagnóstico, as informações obtidas têm se mostrado fundamentais para o estabelecimento de prognósticos e como parâmetro de sucesso dos tratamentos. A presente revisão discute os diversos métodos que podem ser utilizados para a avaliação da circulação pulmonar por imagens existentes nos dias de hoje, desde técnicas amplamente disponíveis e de relativa baixa complexidade técnica, como a radiografia de tórax, até métodos complexos e promissores, como a tomografia de impedância elétrica

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“…MDCTA is superior to MRA in the visualisation of vascular abnormalities and the diagnosis of PH related to lung disease and bronchosystemic shunts [65]. However, the absence of ionising radiation and superior contrast profile favour MRA as a monitoring method.…”

Section: Comparison Of Ct and Mri For The Diagnosis In Pulmonary Hypementioning

confidence: 99%

Pulmonary arterial hypertension: an imaging review comparing MR pulmonary angiography and perfusion with multidetector CT angiography

Junqueira¹,

Lima²,

Coutinho³

et al. 2012

The British Journal of Radiology

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ABSTRACT. Pulmonary hypertension (PH) is a progressive disease that leads to substantial morbidity and eventual death. Pulmonary multidetector CT angiography (MDCTA), pulmonary MR angiography (MRA) and MR-derived pulmonary perfusion (MRPP) imaging are non-invasive imaging techniques for the differential diagnosis of PH. MDCTA is considered the gold standard for the diagnosis of pulmonary embolism, one of the most common causes of PH. MRA and MRPP are promising techniques that do not require the use of ionising radiation or iodinated contrast material, and can be useful for patients for whom such material cannot be used. This review compares the imaging aspects of pulmonary MRA and 64-row MDCTA in patients with chronic thromboembolic or idiopathic PH.

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Assessment of pulmonary hypertension by CT and MR imaging

Cited by 69 publications

References 68 publications

End-points and clinical trial design in pulmonary arterial hypertension: have we made progress?

End-points and clinical trial design in pulmonary arterial hypertension: have we made progress?

O papel dos exames de imagem na avaliação da circulação pulmonar

Pulmonary arterial hypertension: an imaging review comparing MR pulmonary angiography and perfusion with multidetector CT angiography

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