Assessment of Pulmonary Perfusion With Breath-Hold and Free-Breathing Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Ingrisch, Michael; Maxien, Daniel; Schwab, Félix; Reiser, Maximilian; Nikolaou, Konstantin; Dietrich, Olaf

doi:10.1097/rli.0000000000000020

Cited by 27 publications

(27 citation statements)

References 25 publications

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“…Different imaging modalities have been suggested to accomplish this task like magnetic resonance imaging (MRI) [1, 2], scintigraphy [3], single photon emission computed tomography (SPECT) [4], computed tomography (CT) [5], or positron emission tomography (PET) [6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

et al. 2017

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BackgroundIn vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal. Each radiotracer injection was performed simultaneously to the injection of fluorescent microspheres. PBF images were generated applying a two-compartment exchange model over the dynamic PET images. PET and microspheres values were compared by regression analysis and Bland–Altman plot.ResultsThe capability of the proposed technique to produce 3D regional PBF images was demonstrated. The correlation evaluation between 68Ga-DOTA PET and microspheres showed a good and significant correlation (r = 0.74, P < 0.001).ConclusionsAssessment of PBF with the proposed technique allows combining the high quantitative accuracy of PET imaging with the use of 68Ga/68Ge generators. Thus, 68Ga-DOTA PET emerges as a potential inexpensive method for measuring PBF in clinical settings with an extended use.Electronic supplementary materialThe online version of this article (doi:10.1186/s13550-017-0259-2) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

et al. 2017

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“…27 Regarding the more conventional breathhold imaging, a fast sequence is strongly recommended to improve image quality and thus accuracy of measurements. The present study Overview of the measurements in the pulmonary trunk and in the lung parenchyma with indication of the mean S 0 (arbitrary units) and D 0 (milliliters) and their SD as well as their minimum/maximum values for all evaluated contrast agents Gd-DTPA indicates gadopentetate dimeglumine; Gd-BOPTA, gadobenate dimeglumine; S0, value of the asymptote of the exponential function; D0, the contrast dose at which the signal level S0 is reached on the assumption of linearity with the initial slope; SD, standard deviation; Min, minimum; Max, maximum.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach

Veldhoen

Oechsner

Fischer

et al. 2016

Investigative Radiology

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The dual-bolus approach using a 3D FLASH sequence is a feasible tool for quantitative lung perfusion imaging. Small boluses of 3 mL for Gd-DTPA, 1.5 mL for Gd-BOPTA, and 1.5 mL for gadofosveset provide sufficient signal yield for quantitative parenchyma measurements. Using higher boluses falsely lower perfusion values have to be considered due to signal saturation effects. Although gadofosveset yielded the lowest signal, the generated quantitative perfusion maps were of diagnostic quality.

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“…A number of studies have previously developed free‐breathing 1 H MRI lung ventilation measurement pipelines using registration and segmentation methods. A recent study developed a registration‐based approach for free‐breathing 1 H MRI segmentation and required ~55 min to register 200 2D images using ANTs .…”

Section: Discussionmentioning

confidence: 99%

A framework for Fourier‐decomposition free‐breathing pulmonary ¹H MRI ventilation measurements

Guo

Capaldi

McCormack

et al. 2018

Magnetic Resonance in Med

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Purpose To develop a rapid Fourier decomposition (FD) free‐breathing pulmonary 1H MRI (FDMRI) image processing and biomarker pipeline for research use. Methods We acquired MRI in 20 asthmatic subjects using a balanced steady‐state free precession (bSSFP) sequence optimized for ventilation imaging. 2D 1H MRI series were segmented by enforcing the spatial similarity between adjacent images and the right‐to‐left lung volume–ratio. The segmented lung series were co‐registered using a coarse‐to‐fine deformable registration framework that used dual optimization techniques. All pairwise registrations were implemented in parallel and FD was performed to generate 2D ventilation‐weighted maps and ventilation‐defect‐percent (VDP). Lung segmentation and registration accuracy were evaluated by comparing algorithm and manual lung‐masks, deformed manual lung‐masks, and fiducials in the moving and fixed images using Dice‐similarity‐coefficient (DSC), mean‐absolute‐distance (MAD), and target‐registration‐error (TRE). The relationship of FD‐VDP and 3He‐VDP was evaluated using the Pearson‐correlation‐coefficient (r) and Bland Altman analysis. Algorithm reproducibility was evaluated using the coefficient‐of‐variation (CoV) and intra‐class‐correlation‐coefficient (ICC) for segmentation, registration, and FD‐VDP components. Results For lung segmentation, there was a DSC of 95 ± 1.5% and MAD of 2.3 ± 0.5 mm, and for registration there was a DSC of 97 ± 0.8%, MAD of 1.6 ± 0.4 mm and TRE of 3.6 ± 1.2 mm. Reproducibility for segmentation DSC (CoV/ICC = 0.5%/0.92), registration TRE (CoV/ICC = 0.4%/0.98), and FD‐VDP (Cov/ICC = 3.9%/0.97) was high. The pipeline required 10 min/subject. FD‐VDP was correlated with 3He‐VDP (r = 0.69, P < 0.001) although there was a bias toward lower FD‐VDP (bias = −4.9%). Conclusions We developed and evaluated a pipeline that provides a rapid and precise method for FDMRI ventilation maps.

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Assessment of Pulmonary Perfusion With Breath-Hold and Free-Breathing Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Cited by 27 publications

References 25 publications

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach

A framework for Fourier‐decomposition free‐breathing pulmonary ¹H MRI ventilation measurements

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Assessment of Pulmonary Perfusion With Breath-Hold and Free-Breathing Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Cited by 27 publications

References 25 publications

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach

A framework for Fourier‐decomposition free‐breathing pulmonary 1H MRI ventilation measurements

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Product

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A framework for Fourier‐decomposition free‐breathing pulmonary ¹H MRI ventilation measurements