Aims:The aim of this study was to compare the push-out bond strength values between four different types of sealers. Materials and method: Forty extracted straight, single-rooted, sound human mandibular first premolar teeth were selected for this study. The crown portion of each tooth was decoronated to the level of the cement-enamel junction (CEJ) to standardize the root length to 16 mm. The working length was measured and the canals were instrumented using Nickel-Titanium ProTaper Universal Rotary System up to size F3. The canals were rinsed with 2.5% sodium hypochlorite followed by 17% EDTA, then the samples were divided into four groups (n=10) according to the sealer to be used with F3 gutta-percha. These are (AH Plus, GuttaFlow 2, GuttaFlow Bioseal and MTA Fillapex) sealers. The pushout bond strength test was performed and the data were analyzed using one way ANOVA, and post hoc Duncan's multiple range tests at (p ≤ 0.05). Results: There was a statistically significant difference in the push-out bond strength among the four sealers' groups at (p ≤ 0.05). The highest mean value of bond strength (3.605) MPa was shown in the AH Plus group. Bioseal group produced (1.833) MPa followed by (0.822) MPa for GuttaFlow2 group. The lowest value (0.645) MPa was shown in MTA Fillapex group. Conclusion: Based on the findings of this study, AH Plus sealer revealed the highest bond-strength value followed by GuttaFlow Bioseal and GuttaFlow 2, whereas MTA Fillapex showed the least bond value.