Assessment of PVA/silver nanocomposite hydrogel patch as antimicrobial dressing scaffold: Synthesis, characterization and biological evaluation

Bhowmick, Sirsendu; Koul, Veena

doi:10.1016/j.msec.2015.10.003

Cited by 128 publications

(64 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The minimum inhibitory concentration of AgNPs is estimated to be 7.81 µg/ml for Staphylococcus aureus (gram positive) andEscherichia coli (gram negative) whereas 3.90 µg/ml for Pseudomonas aeruginosa (gram negative) and showed antimicrobial efficacy in slow release in controlled manner and retained, even after 96 h of release of AgNPs, suggesting as reservoir for AgNPs to maintain a sterile and moist environment for a long duration wound healing. In addition, hydrogel scaffold showed increased swelling property, mechanical property, high water content (for exudate absorption) and easy peal ability[137].Further, the use of cell adhesion molecules in PVA hydrogels may be useful to impart synergistic and tunable behavior of adhesion for successful application in vascular tissue engineering applications. Rafatet al 2012 synthesized PVA hydrogels functionalized with antibodies against vascular cell adhesion molecules-1 (VCAM1) and endothelial leukocyte adhesion molecule-1 (E-Selectin) to mimicleukocyte-endothelial cells interactions.…”

mentioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

385

161

View full text Add to dashboard Cite

Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed. GRAPHICAL ABSTRACTDownloaded by [University of Sussex Library] at 08:36 28 June 2016 2

show abstract

mentioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

385

161

View full text Add to dashboard Cite

show abstract

“…Similar antibacterial activity for the non-stored and non-filled samples was not observed for E. coli , although Farah et al [47] and Lu et al [48] investigated the use of polymeric materials and reported significantly higher antibacterial activity against S. aureus than for E. coli . Several studies have reported that for antimicrobial additives and polymers, the effect against S. aureus was lower than that against E. coli [45,49,50], a difference that indicates significant variability in the results.…”

Section: Discussionmentioning

confidence: 99%

Effect of Storage in Distilled Water for Three Months on the Antimicrobial Properties of Poly(methyl methacrylate) Denture Base Material Doped with Inorganic Filler

et al. 2016

View full text Add to dashboard Cite

The colonization of poly(methyl methacrylate) (PMMA) denture base materials by pathogenic microorganisms is a major problem associated with the use of prostheses, and the incorporation of antimicrobial fillers is a method of improving the antimicrobial properties of these materials. Numerous studies have demonstrated the initial in vitro antimicrobial effectiveness of this type of material; however, reports demonstrating the stability of these fillers over longer periods are not available. In this study, silver sodium hydrogen zirconium phosphate was introduced into the powder component of a PMMA denture base material at concentrations of 0.25%, 0.5%, 1%, 2%, 4%, and 8% (w/w). The survival rates of the gram-positive bacterium Staphylococcus aureus, gram-negative bacterium Escherichia coli and yeast-type fungus Candida albicans were established after fungal or bacterial suspensions were incubated with samples that had been previously stored in distilled water. Storage over a three-month period led to the progressive reduction of the initial antimicrobial properties. The results of this study suggest that additional microbiological tests should be conducted for materials that are treated with antimicrobial fillers and intended for long-term use. Future long-term studies of the migration of silver ions from the polymer matrix and the influence of different media on this ion emission are required.

show abstract

“…The reaction mixture was kept under continuous stirring for (15 min). The reaction medium acquires a clear yellow color indicating the formation of silver nanoparticles (Bhowmick and Koul, 2016).…”

Section: Preparation Of Silver Nanoparticles (Agnps) By Polyvinyl Alcmentioning

confidence: 99%

“…Hydrogel widely used in medical industry such as wound dressing, scaffold, contact lenses, controlled drug release and etc (Bhowmick and Koul, 2016;Catanzano et al, 2015;Silva et al, 2015;Pairatwachapun et al, 2016;Mabry et al, 2015). Hydrogels prepared in physical and chemical ways.…”

Section: Introductionmentioning

confidence: 99%

Physical, Mechanical and Antimicrobial Evaluations of Physically Crosslinked PVA/Chitosan Hydrogels Containing Nanoparticles

Montaser¹

2016

J App Pharm Sci

View full text Add to dashboard Cite

Chitosan/montmorillonite (MMT) and Poly vinyl Alcohol (PVA) / Silver nanoparticles (AgNPs) nanocomposites were prepared and formed hydrogel membranes using freeze thawing technique. The properties of the prepared hydrogels were investigated and compared to hydrogel membranes in presence and absence of nanometals. The physical behavior, mechanical properties and antibacterial activity was examined. Also the surface morphology monitored using scanning electron microscope. Antimicrobial activity against bacteria and yeast was also examined. The obtained results showed positive effect of nanometals especially AgNPs on swelling percent on the other hand tensile strength were combined by presence of MMT nanoparticles. The surface morphology showed homogenous images for all samples except samples containing MMT. All prepared samples containing nanoparticles showed antibacterial activity especially hydrogel membranes containing AgNPs.

show abstract

Assessment of PVA/silver nanocomposite hydrogel patch as antimicrobial dressing scaffold: Synthesis, characterization and biological evaluation

Cited by 128 publications

References 96 publications

PVA-based hydrogels for tissue engineering: A review

PVA-based hydrogels for tissue engineering: A review

Effect of Storage in Distilled Water for Three Months on the Antimicrobial Properties of Poly(methyl methacrylate) Denture Base Material Doped with Inorganic Filler

Physical, Mechanical and Antimicrobial Evaluations of Physically Crosslinked PVA/Chitosan Hydrogels Containing Nanoparticles

Contact Info

Product

Resources

About