Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ-C30 and H&amp;N-35 modules

Cengiz, Mustafa; Özyar, Enis; Esassolak, Mustafa; Altun, Musa; Akmansu, Müge; Şen, Mehmet; Uzel, Ömer; Yavuz, Aydın; Dalmaz, Gamze; Uzal, Cem; Hiçsönmez, A; Sarıhan, Süreyya; Kaplan, Bünyamin; Atasoy, Beste Melek; Ulutin, Cüneyt; Abacıoğlu, Ufuk; Demiral, Ayşe Nur; Hayran, Mutlu

doi:10.1016/j.ijrobp.2005.05.057

Cited by 47 publications

(37 citation statements)

References 14 publications

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“…Eighteen suitable datasets were obtained [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Table 1 summarises their characteristics and the number of observations each contributed to various psychometric analyses.…”

Section: Resultsmentioning

confidence: 99%

QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30

et al. 2016

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Abstract:Purpose: To derive a health state classification system (HSCS) from the cancerspecific quality of life questionnaire, the EORTC QLQ-C30, as the basis for a multiattribute utility instrument.Methods: The conceptual model for the HSCS was based on the established domain structure of the QLQ-C30. Several criteria were considered to select a subset of dimensions and items for the HSCS. Expert opinion and patient input informed a priori Powered by Edit orial Manager® and ProduXion Manager® from Aries Syst em s Corporat ionselection of key dimensions. Psychometric criteria were assessed via secondary analysis of a pooled dataset comprising HRQOL and clinical data from 2616 patients from eight countries and a range of primary cancer sites, disease stages, and treatments. We used confirmatory factor analysis (CFA) to assess the conceptual model's robustness and generalisability. We assessed item floor effects (>75% observations at lowest score), disordered item response thresholds, coverage of the latent variable and differential item function (DIF) using Rasch analysis. We calculated effect sizes for known group comparisons based on disease stage and responsiveness to change. Seventy-nine cancer patients assessed the relative importance of items within dimensions.Results: CFA supported the conceptual model and its generalizability across primary cancer sites. After considering all criteria, 12 items were selected representing 10 dimensions: physical functioning (mobility), role functioning, social functioning, emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems.

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Section: Resultsmentioning

confidence: 99%

QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30

et al. 2016

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“…A recent report from Turkey indicated that the factors with an adverse impact on the QOL of NPC survivors who received conventional RT included advanced stage, female gender, and long-term follow-up. 18 In contrast, we previously reported that socioeconomic status and comorbidity, rather than tumor-or therapy-related variables, were correlated significantly with the QOL of NPC survivors who received conventional RT. 19 The current study reiterated those results and also showed that patients who received conformal RT had a 2-fold higher probability of reporting a good global QOL compared with patients who received conventional RT in a logistic regression model.…”

Section: Discussionmentioning

confidence: 72%

“…13,14 QOL is an important component of the analysis of treatment results, and validated QOL tools specific for the assessment of head and neck cancer, such as the University of Washington Quality of Life instrument and the European Organization for the Research and Treatment of Cancer (EORTC)-Head and Neck-specific Quality of Life Questionnaire module (QLQ-H&N35), are being used increasingly to assess patient-centered treatment outcomes. [15][16][17][18] It has become critical to include these tools to monitor the therapeutic index of different treatment modalities, such as 2D-RT versus 3D-CRT or IMRT.…”

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confidence: 99%

Intensity‐modulated or conformal radiotherapy improves the quality of life of patients with nasopharyngeal carcinoma

Fang

Tsai

Chen

et al. 2007

Cancer

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BACKGROUND.It was reported previously that the dosimetric superiority of conformal radiotherapy (RT), either 3‐dimensional conformal RT (3D‐CRT) or intensity‐modulated RT (IMRT), over conventional 2D‐RT translated into clinical benefits for patients with nasopharyngeal carcinoma (NPC). In this study, the authors compared quality‐of‐life (QOL) outcomes of NPC survivors who received treatment with 1 of 4 different RT techniques at a single institute during different periods.METHODS.The authors analyzed QOL data of from 237 patients with NPC who were cancer free for 2 or 3 years when their QOL was assessed. The study population included 152 patients who received conventional RT (2D‐RT, 61 patients; 2D‐RT plus 3D‐CRT boost, 91 patients) and 85 patients who received conformal RT (3D‐CRT, 33 patients; IMRT, 52 patients). The European Organization for the Research and Treatment of Cancer (EORTC) Core QOL questionnaire and the EORTC Head and Neck QOL questionnaire were completed.RESULTS.Compared with patients who received with conventional RT, patients who received conformal RT had both statistically (P < .05) and clinically (a difference in mean scores ≥10 points) significant improvements in the scales of global QOL, pain, appetite loss, senses, speech, social eating, teeth, opening mouth, xerostomia, sticky saliva, and feeling ill. No significant difference was observed in any of the scales that compared 2D‐RT with 2D‐RT plus 3D‐CRT boost or that compared 3D‐CRT with IMRT. Survivors who received conformal RT had a 2.01‐fold higher probability (odds ratio [OR], 2.01; 95% confidence interval [95% CI], 1.19–3.68) of reporting good global QOL and a 2.70‐fold lower probability (OR, 0.37; 95% CI, 0.20–0.66) of reporting a high level of xerostomia than survivors who received conventional RT.CONCLUSIONS.Conformal RT substantially improved head and neck‐related symptoms and broad aspects of QOL for survivors of NPC. Cancer 2007. © 2006 American Cancer Society.

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“…The most frequent side effects are xerostomy, otitis media, trismus and severe neck fibrosis. 18 A randomized study of 229 patients with advanced stage tumors showed that radiotherapy alone or with chemotherapy did not improve local and regional control indices. 19 Another randomized trial from the Intergroup Study 0099 demonstrated improved disease remission rates by using chemotherapy with radiotherapy in advanced stage tumors; in this study, 3-year disease-free survival was 69% compared to 24% when treated with radiotherapy alone.…”

Section: Discussionmentioning

confidence: 99%

Avaliação dos fatores clínicos e do tratamento em pacientes com carcinoma indiferenciado da nasofaringe

Chedid

Franzi

Dedivitis

2008

Rev. Bras. Otorrinolaringol.

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The nasopharyngeal carcinoma (NPC) is a rare cancer with a high incidence in Southern Asia. Aim: to study the demographic, clinical, therapeutic, and prognostic factors of nasopharyngeal undifferentiated carcinoma in a reference service. Materials and methods: A retrospective study was made of 46 patients from January 1998 to August 2000. The patients had no previous treatment and did not present any evidence of synchronous tumors or distance metastases. Results: The age ranged from 14 to 78 years (mean = 46 years); 35 (76%) patients were male. All patients were Caucasian or African-Brazilian. The onset of initial symptoms ranged from 1 to 48 months (mean = 7 months); 47% of the subjects smoked tobacco and 33% consumed alcoholic beverages. A lump in the neck was the most frequent symptom (34 patients). Twenty-two patients were clinically staged as T1/T2 and 24 patients as T3/T4; 24 patients were classified as N2, and 16 patients were staged as N3. Curative treatment consisted of radiotherapy and simultaneous chemotherapy in clinical stages III and IV. Of 27 patients that were monitored, 52% were alive with no evidence of disease after three years. Conclusion: All patients were in advanced clinical stages of the disease. The three-year disease-free survival rate was 52%.

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Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ-C30 and H&N-35 modules

Cited by 47 publications

References 14 publications

QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30

QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30

Intensity‐modulated or conformal radiotherapy improves the quality of life of patients with nasopharyngeal carcinoma

Avaliação dos fatores clínicos e do tratamento em pacientes com carcinoma indiferenciado da nasofaringe

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