Assessment of radiation-induced otitis media in patients with parotid gland malignancy

Na, Gina; Kim, Kyung Hwan; Byun, Hwa Kyung; Bae, Seong Hoon

doi:10.1080/00016489.2021.1892184

Cited by 3 publications

(11 citation statements)

References 16 publications

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“…It is considered non-purulent, and bacterial culture results are usually negative. 9 As a result, OME is often classified as a non-infectious condition according to consensus guidelines such as the International Consensus of the World Federation of Otorhinolaryngology (2017, Paris), which defines OME as middle ear effusion without signs of ear infection.…”

Section: Discussionmentioning

confidence: 99%

“…It is considered non-purulent, and bacterial culture results are usually negative. 9 As a result, OME is often classified as a non-infectious condition according to consensus guidelines such as the International Consensus of the World However, some researchers believe that bacterial infection and the associated inflammatory response have an impact on the onset of OME. 10 Previous experiments have explored the connection between infection and radiotherapy-reduced OME as well.…”

Section: The Clinical Etiology Of Otitis Media With Effusionmentioning

confidence: 99%

“…22 Postradiation OME is a prevalent otologic adverse effect observed among patients with NPC treated with radiotherapy. 9,22 Although the basic etiology of both types of secretory otitis media involves neg-pressure in patient's tympanic cavity resulting in the exudation of capillary blood serum and the formation of middle ear effusion, the course and characteristics of the diseases differ. 2 Hence, our study aimed to explore the differences between the two types of secretory otitis media at the protein level.…”

Section: Comparison Of Ome and Serum Proteomementioning

confidence: 99%

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Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion

Wang,

Xu,

Feng

et al. 2023

IDR

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Background: Proteins found in middle ear effusion play crucial roles in the physiological and pathological processes of otitis media with effusion (OME), influencing the etiology and clinical characteristics of this disease. The qualitative and quantitative composition of these proteins depending on the underlying pathogenesis of middle ear effusion. Understanding their physiological and pathological functions is of great importance. Methods: We collected samples from 19 volunteers diagnosed with OME. After offline separation using high-pH reversed-phase liquid chromatography (RPLC), the pooled sample was subjected to LC-MS/MS analysis to obtain a comprehensive profile of the OME proteome. Functional analysis was performed using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Ingenuity Pathway Analysis (IPA) annotations. Data-independent acquisition (DIA) technology was utilized to analyze samples and fix whether the OME proteome could replicate the pathophysiological features associated with this disease. We conducted a differential proteomic analysis between patients with simple OME and patients who had received radiotherapy. The radiotherapyreduced group was further divided into two subgroups: nasopharyngeal carcinoma (NPC) and other types of carcinoma. Parallel reaction monitoring (PRM) technology was used for validation of 36 differentially expressed proteins (DEPs). Results: A number of 732 proteins were identified in the OME proteome database. Among them, 527 proteins were quantified using peak intensity-based semi-quantification (iBAQ), covering a wide dynamic range of approximately 8 orders of magnitude. Based on the functional analysis, we proposed a hypothetical mechanism of OME. Conclusion:This study managed to put up an inclusive analysis of the OME proteome, establishing the first human OME proteome database. We focused on differential proteomic analysis among different groups to gain a more comprehensive concept of the OME proteome and search for meaningful biomarkers.

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Section: Discussionmentioning

confidence: 99%

“…It is considered non-purulent, and bacterial culture results are usually negative. 9 As a result, OME is often classified as a non-infectious condition according to consensus guidelines such as the International Consensus of the World However, some researchers believe that bacterial infection and the associated inflammatory response have an impact on the onset of OME. 10 Previous experiments have explored the connection between infection and radiotherapy-reduced OME as well.…”

Section: The Clinical Etiology Of Otitis Media With Effusionmentioning

confidence: 99%

Section: Comparison Of Ome and Serum Proteomementioning

confidence: 99%

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Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion

Wang,

Xu,

Feng

et al. 2023

IDR

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“…The imaging studies included computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scans. The imaging findings of otitis media were soft tissue density in CT or PET-CT scans and higher signal intensity than the turbinate mucosa or similar intensity to cerebrospinal fluid in T2-weighted MRI images [ 10 ]. These findings in the middle ear cavity, antrum, or nearby air cells confirmed otitis media.…”

Section: Methodsmentioning

confidence: 99%

“…Anatomically, several factors increase the prevalence of otitis media after total laryngectomy. For instance, nasal airflow exclusion, decreased swallowing function, esophageal reflux, and postoperative radiation therapy can affect the middle ear status [6][7][8][9][10]. However, the incidence of otitis media following laryngectomy is not well investigated and there have been no recent studies regarding its mechanism.…”

Section: Introductionmentioning

confidence: 99%

Patients Requiring Gastrostomy Tube Insertion After Total Laryngectomy Have a Higher Incidence of Otitis Media

et al. 2022

Self Cite

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Background and Objectives: Some reports propose an increased risk of otitis media and hearing impairment after total laryngectomy. However, the incidence of otitis media following laryngectomy and the mechanism remain unclear. This study aimed to identify the incidence and risk factors of otitis media after total laryngectomy.Subjects and Methods: This retrospective cohort study assessed 77 patients who underwent total laryngectomy from 2010 to 2020 in a tertiary referral center. Serial imaging studies (computed tomography [CT], magnetic resonance imaging, and positron emission tomography-CT) were used to assess otitis media.Results: The study enrolled 58 patients (mean age, 67.0±7.7 years; male, 56 [96.6%]); nine (15.5%) underwent a gastrostomy tube (four preoperatively and five postoperatively). Otitis media was confirmed in seven (12.1%) patients. Gastrostomy tube insertion was the only significant risk factor for otitis media (p=0.012). Of the nine patients who underwent gastrostomy tube insertion, four developed otitis media; all four had the procedure after laryngectomy.Conclusions: This study found an increased incidence of otitis media after total laryngectomy. Swallowing difficulties likely contribute to otitis media as it occurred more frequently in patients requiring postoperative gastrostomy tube insertion.

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Diagnóstico de otitis media con efusión en adultos

Thone M.,

Iribarren,

Jofré P.

2023

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Assessment of radiation-induced otitis media in patients with parotid gland malignancy

Cited by 3 publications

References 16 publications

Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion

Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion

Patients Requiring Gastrostomy Tube Insertion After Total Laryngectomy Have a Higher Incidence of Otitis Media

Diagnóstico de otitis media con efusión en adultos

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