Assessment of recovery time for the collagen products Dermicol-P35 27G and 30G

Solish, Nowell

doi:10.1016/j.jaad.2009.08.016

Cited by 7 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together with the current study, this literature highlights the potential of biomaterial hydrogel scaffolds to improve the outcome of reparative cell therapies for Parkinson’s disease. Moving towards a clinical therapy, the use of bovine collagen is already approved for a variety of applications including drug delivery, wound healing, burn repair, dentistry and bone reconstruction 17 , 18 , 20 , 39 – 42 , and could therefore, be relatively easily adopted for neural applications. However, given the ethical and logistical limitations of using fetal-derived tissue for brain repair, in future studies, it will be important to determine if collagen scaffolds can also improve the outcome of stem cell-derived dopaminergic neuron transplants in the Parkinsonian brain.…”

Section: Discussionmentioning

confidence: 99%

Encapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantation

Moriarty

Pandit

Dowd

2017

Sci Rep

View full text Add to dashboard Cite

Poor graft survival limits the use of primary dopaminergic neurons for neural repair in Parkinson’s disease. Injectable hydrogels have the potential to significantly improve the outcome of such reparative approaches by providing a physical matrix for cell encapsulation which can be further enriched with pro-survival factors. Therefore, this study sought to determine the survival and efficacy of primary dopaminergic grafts after intra-striatal delivery in a glial-derived neurotrophic factor (GDNF)-loaded collagen hydrogel in a rat model of Parkinson’s disease. After intra-striatal transplantation into the lesioned striatum, the GDNF-enriched collagen hydrogel significantly improved the survival of dopaminergic neurons in the graft (5-fold), increased their capacity for striatal re-innervation (3-fold), and enhanced their functional efficacy. Additional studies suggested that this was due to the hydrogel’s ability to retain GDNF in the microenvironment of the graft, and to protect the transplanted cells from the host immune response. In conclusion, the encapsulation of dopaminergic neurons in a GDNF-loaded hydrogel dramatically increased their survival and function, providing further evidence of the potential of biomaterials for neural transplantation and brain repair in neurodegenerative diseases such as Parkinson’s disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Encapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantation

Moriarty

Pandit

Dowd

2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Its decreased synthesis and replacement rate causes matrix loss and thus skin collapse and loss of elasticity, which in turn leads to the appearance of wrinkles, folds, and facial contour changes, as masterfully described by Fisher et al 2008 [ 215 ]. Due to this, several commercial collagen-based products are available and are used principally for facial contouring, such as for nasolabial folds [ 2 , 67 , 76 , 86 , 87 , 96 , 149 , 163 , 172 , 205 , 206 , 207 , 208 ], nasojugal folds [ 152 ], lip [ 2 , 77 , 95 , 148 , 169 , 172 ], cheek and temple area [ 172 ], glabellar groove [ 77 ], post-rhinoplasty dorsal irregularities [ 77 , 209 ], depressed acne scars [ 77 , 172 , 210 ], augmentation [ 96 , 172 ].…”

Section: Clinical Efficacy Of Collagen-based Injectable Implantsmentioning

confidence: 99%

“…In the case of patients not wishing to undergo surgery, an easier procedure would generally be more accepted. Moreover, compared to undergoing more invasive surgery, fillers offer the patient less discomfort and a shorter recovery time, making them very practical in the resolution of minor-serious disease and allowing patients to return immediately to their daily routine [ 1 , 2 ]. Minimally invasive therapies would give a better quality of life also for that part of population that would otherwise not survive the trauma induced by conventional surgeries.…”

Section: Introductionmentioning

confidence: 99%

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Salvatore¹,

Natali

Brunetti³

et al. 2023

Polymers

View full text Add to dashboard Cite

Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strategies. Among them, collagen-based products are revealed to be one of the most promising among bioactive biomaterials-based formulations. Collagen is the most abundant structural protein of vertebrate connective tissues and, because of its structural and non-structural role, is one of the most widely used multifunctional biomaterials in the health-related sectors, including medical care and cosmetics. Indeed, collagen-based formulations are historically considered as the “gold standard” and from 1981 have been paving the way for the development of a new generation of fillers. A huge number of collagen-based injectable products have been approved worldwide for clinical use and have routinely been introduced in many clinical settings for both aesthetic and regenerative surgery. In this context, this review article aims to be an update on the clinical outcomes of approved collagen-based injectables for both aesthetic and regenerative medicine of the last 20 years with an in-depth focus on their safety and effectiveness for the treatment of diseases of the integumental, gastrointestinal, musculoskeletal, and urogenital apparatus.

show abstract

“…Keeping with this, collagen biomaterials have already been approved for use in a variety of applications including drug delivery, wound repair, burn treatment, dentistry and bone reconstruction (Blume et al, 2011;Chajra et al, 2008;Chattopadhyay & Raines, 2014;El-Chaar, 2016;Helary et al, 2010;Khan & Khan, 2013;Parenteau-Bareil, Gauvin, & Berthod, 2010;Patino, Neiders, Andreana, Noble, & Cohen, 2002;Solish, 2010) and could therefore be relatively easily adopted to neural applications. While the intracranial use of collagen hydrogels has been looked at to a lesser extent, Hoban et al (2013) and Moriarty et al (2017 have recently demonstrated the efficacy of PEG cross-linked collagen hydrogels for brain repair in Parkinson's disease.…”

Section: Injectable Collagen Hydrogelsmentioning

confidence: 99%

“…Taken together, this literature highlights the potential of biomaterial hydrogel scaffolds to improve the outcome of reparative cell therapies for Parkinson's disease. Moving towards a clinical therapy, the use of biomaterial scaffolds from natural polymers, namely collagen, offers significant translatability owing to it already being approved for use in a variety of clinical applications (Chajra et al., ; Chattopadhyay & Raines, ; Patino et al., ; Solish, ).…”

Section: Cellular Brain Repair For Parkinson's Disease – Which Biomatmentioning

confidence: 99%

Primary tissue for cellular brain repair in Parkinson's disease: Promise, problems and the potential of biomaterials

Moriarty

Parish

Dowd

2018

Eur J of Neuroscience

View full text Add to dashboard Cite

The dopamine precursor, levodopa, remains the "gold standard" treatment for Parkinson's disease, and, although it provides superlative efficacy in the early stages of the disease, its long-term use is limited by the development of severe motor side effects and a significant abating of therapeutic efficacy. Therefore, there remains a major unmet clinical need for the development of effective neuroprotective, neurorestorative or neuroreparatory therapies for this condition. The relatively selective loss of dopaminergic neurons from the nigrostriatal pathway makes Parkinson's disease an ideal candidate for reparative cell therapies, wherein the dopaminergic neurons that are lost in the condition are replaced through direct cell transplantation into the brain. To date, this approach has been developed, validated and clinically assessed using dopamine neuron-rich foetal ventral mesencephalon grafts which have been shown to survive and reinnervate the denervated brain after transplantation, and to restore motor function. However, despite long-term symptomatic relief in some patients, significant limitations, including poor graft survival and the impact this has on the number of foetal donors required, have prevented this therapy being more widely adopted as a restorative approach for Parkinson's disease. Injectable biomaterial scaffolds have the potential to improve the delivery, engraftment and survival of these grafts in the brain through provision of a supportive microenvironment for cell adhesion, growth and immune shielding. This article will briefly review the development of primary cell therapies for brain repair in Parkinson's disease and will consider the emerging literature which highlights the potential of using injectable biomaterial hydrogels in this context.

show abstract

Assessment of recovery time for the collagen products Dermicol-P35 27G and 30G

Cited by 7 publications

References 20 publications

Encapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantation

Encapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantation

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Primary tissue for cellular brain repair in Parkinson's disease: Promise, problems and the potential of biomaterials

Contact Info

Product

Resources

About