In modern urban construction, digitalization has become a trend, but the single source of information of traditional algorithms can not meet people’s needs, so the data fusion technology needs to draw estimation and judgment from multisource data to increase the confidence of data, improve reliability, and reduce uncertainty. In order to understand the influencing factors of regional digitalization, this paper conducts multisource heterogeneous data fusion analysis based on regional digitalization of machine learning, using decision tree and artificial neural network algorithm, compares the management efficiency and satisfaction of school population under different algorithms, and understands the data fusion and construction under different algorithms. According to the results, decision-making tree and artificial neural network algorithms were more efficient than traditional methods in building regional digitization, and their magnitude was about 60% higher. More importantly, the machine learning-based methods in multisource heterogeneous data fusion have been better than traditional calculation methods both in computational efficiency and misleading rate with respect to false alarms and missed alarms. This shows that machine learning methods can play an important role in the analysis of multisource heterogeneous data fusion in regional digital construction.