Assessment of Renal Functions in Infants and Children with Congenital Heart Diseases

Mohamed, Mohamed Seif; Rabeea, Moftah; Saif, Hassan Saad Abu; Hammad, Kamel Soliman

doi:10.21608/ejhm.2019.22838

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Our results came in the same line with Mohamed et al [23], who studied assessment of renal functions in infants and children with congenital heart diseases, found that children with cyanotic CHD had higher values in all parameters (Estimated glomerular filtration rate (EGFR) and urinary albumin and creatinine ratio), and concluded that risk of renal dysfunctions increase by time especially in children with cyanotic CHD which may be due to effect of chronic hypoxia and other conditions such as polycythemia.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of the Insulin like growth factor (IGF) and thyroid function in patients with cyanotic congenital heart disease

Shaheen

Khattab

Amer

et al. 2022

Benha Journal of Applied Sciences

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Background: Children with congenital heart disease (CHD) have been reported to show significant growth retardation both prenataly and postnatally. Cyanotic CHDs in children commonly cause more pronounced growth retardation in comparison with acyanotic CHDs. Chronic hypoxemia has been suggested as the cause of poor growth in these patients. Interruption of GH / IGF-1 axis decreased appetite due to hypoxemia leading to insufficient food intake and increased energy consumption may be a cause of the increased growth failure in patients with cyanotic CHDs. The relationship between cyanotic CHDs, malnutrition and growth retardation is well documented. The aim of this study was to investigate the effects of cyanosis and chronic hypoxia on plasma level of insulin-like growth factor-1 and to examine the prevalence of elevated TSH in the patients with cyanotic congenital heart diseases. Methods: This study had two groups; Cases group: included 30 patients with cyanotic CHD, who admitted to the Pediatric Cardiology Outpatient Clinic of benha university hospital, Another 35 patients, who admitted to the Pediatric Outpatient Clinic with several complaints, including headache or abdominal discomfort or for scheduled vaccination visits were included in the control group. Results: The mean age in the studied cases was 24.1±13.8 months, ranged from 3-60 months, and consists of 18 males and 12 females, the mean age in the control group was 21.8±12.6 months, ranged from 3-60 months, and consists of 18 males and 17 females. There was no statistical difference between cases and control groups regarding age, or sex. The most frequent diagnosis in our study, was TOF (46.7%), then TGA (40%), All the studied cases had history of previous hospital admission, and 40% of cases had history of previous PICU admission.There was statistical significant difference between studied groups regarding anthropometric measures, as weight, height and BMI centiles were statistically lower in cases group, while there was no significant difference between groups regarding head circumference. There was Hb and WBCs were statistically higher in cases group, while platelets were statistically lower in cases group, compared to control group (p<0.001). Serum urea and creatinine were significantly higher in cases group compared to control group (p<0.001, and p=0.42, respectively). While there was no significant difference between groups regarding random blood sugar, serum Ca , serum K, serum Na and serum phosphorus. Insulin-Like Growth Factor (IGF-1) was statistically higher in cases group (60.4±24.3 ng/mL), compared to control group (141.2±45.6 ng/mL), p<0.001.There was no significant difference between groups regarding thyroid function tests. Seven children (23.3%) in cases group had subclinical hypothyroidism, while 4 children (11.4%) of control group had subclinical hypothyroidism, but no significant difference were found.There was a significant difference between IGF-1 regarding sex as it was significantly lower in males (48±12.95 ng/mL) compared to females ...

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Section: Discussionsupporting

confidence: 91%

Evaluation of the Insulin like growth factor (IGF) and thyroid function in patients with cyanotic congenital heart disease

Shaheen

Khattab

Amer

et al. 2022

Benha Journal of Applied Sciences

View full text Add to dashboard Cite

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“… 10 Mohamed et al also found that patients with cyanotic CHD were at increased risk of both tubular and glomerular dysfunction in comparison to acyanotic CHD patients. 11 Nevertheless, the current study showed no significant relationship between renal abnormalities and patient's oxygen saturation status (P = 0.582).…”

Section: Discussioncontrasting

confidence: 69%

Anatomical Findings of Renal and Urological Abnormalities in Cardiac Catheterization of Children with congenital heart diseases – A Single Center Experience

Khalilian

Mollatayefeh

Tahouri

et al. 2021

Qatar Medical Journal

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Background and aims: Congenital heart disease (CHD) is described as an abnormality in the heart structure or intra-thoracic great vessels that leads to functional problems. Since most of these disorders require medical and surgical interventions identifying concomitant disorders such as renal and urinary tract abnormalities is of great importance in the management of these patients. The present study aimed to investigate the relative frequency of abnormal kidney and urinary tract findings in abdominal cineangiography during cardiac catheterization of patients with CHD in Shahid Modarres Cardiovascular Medical and Research Center. Methods: The present study was performed prospectively on 545 patients aged < 18 years with CHD who underwent cardiac catheterization and concurrent abdominal cineangiography in Shahid Modarres Cardiovascular, Medical and Research Center, Tehran, Iran during a three-year period. The required data were extracted using a researcher-made questionnaire from patients’ electronic medical files. Results: Of a total of 545 patients in this study, 26 had both CHD and renal or urinary tract malformation. Patent ductus arteriosus was the most common CHD in patients with renal or urinary tract malformations (odds ratio: 1.2, 95%, CI: 2.25–11.63). In this study, the most common renal and urinary malformations among CHD patients was partial duplication of the kidney followed by Ureteropelvic Junction Obstruction.Conclusion: Since the prevalence of renal and urinary tract malformations is higher in CHD patients, performance of concurrent abdominal cineangiography during cardiac catheterization may lead to early diagnosis and treatment as well as better pre- and post-operative management of patients.

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Assessment of Renal Functions in Infants and Children with Congenital Heart Diseases

Cited by 2 publications

References 6 publications

Evaluation of the Insulin like growth factor (IGF) and thyroid function in patients with cyanotic congenital heart disease

Evaluation of the Insulin like growth factor (IGF) and thyroid function in patients with cyanotic congenital heart disease

Anatomical Findings of Renal and Urological Abnormalities in Cardiac Catheterization of Children with congenital heart diseases – A Single Center Experience

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