Assessment of Renal Graft Function Depending on Pre-Transplant Morphology

Lubuska, Lucie; Bachleda, Petr; Tichý, Tomáš; Ľubušký, Marek; Utíkal, P; Hrabalová, Monika; Chudáček, Josef; Janout, Vladimí­r

doi:10.5507/bp.2006.026

Cited by 4 publications

(4 citation statements)

References 25 publications

(49 reference statements)

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“…Arias et al, 20 in a multivariate analysis, showed that chronic alterations in all compartments were associated with worse graft survival. On the other hand, Lubuska et al 21 did not find a negative influence of histopathological alterations in long term graft functioning.…”

Section: Resultsmentioning

confidence: 88%

Histopathological analysis of pre-implantation donor kidney biopsies: association with graft survival and function in one year post-transplantation

Pêgas¹,

Michel²,

Garcı́a³

et al. 2014

Jornal Brasileiro De Nefrologia

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Section: Resultsmentioning

confidence: 88%

Histopathological analysis of pre-implantation donor kidney biopsies: association with graft survival and function in one year post-transplantation

Pêgas¹,

Michel²,

Garcı́a³

et al. 2014

Jornal Brasileiro De Nefrologia

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“…Many researchers studying renal allograft Time-Zero biopsies have reported that latent pathological changes in donor kidneys affect the postoperative renal function of the recipient, and this could help predict long-term survival [9, 10]. A meta-analysis analyzed 16 clinical research reports on renal allograft biopsy in Europe and concluded that glomerulosclerosis, arteriolopathy, and renal interstitial lesions affect long-term survival of a renal graft [11].…”

Section: Discussionmentioning

confidence: 99%

“…Lubuska et al [9] observed various graded pathological changes of living donor kidneys and classified arterial pathological changes into four grades according to the extent of thickening and hyalinization of the arteriolar wall. Grade 0 is defined as no pathological change; Grade 1 as pathological change not exceeding 25%; Grade 2 as pathological change of 25–50%; and Grade 3 as pathological change exceeding 50%.…”

Section: Discussionmentioning

confidence: 99%

Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients

Zhang

et al. 2013

Clinical and Developmental Immunology

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Objective. This study evaluated the long-term effects and clinical significance of latent abnormal pathology on elder living donor kidney graft function after renal transplantation in China. Methods. One-hundred and thirty-eight living donor renal transplantations have been carried out at our hospital in recent years. Of these, 72 Time-Zero biopsies were performed and used in this analysis. Clinical data were retrospectively measured at 3, 6, 12, and 24 months after renal transplants. Relationships and effects from biopsy results taken from implanted donor kidney grafts were analyzed. Results. Time-Zero biopsy pathology results from donor kidneys showed that 48.61% of donor kidneys had latent abnormal changes; arterial lesions of donor kidneys had significant effects on the renal function of grafts after 2 years' transplantation; correlations between donor age and arterial lesions were significant; and Time-Zero biopsy pathology results could help predict the long-term function of a renal graft. Conclusions. Existing latent pathological changes of an elder living donor kidney before transplantation could affect long-term renal function. Whether a senior donor is used should be very carefully considered.

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“…13,14 Histopathological assessment of kidneys is a part of the comprehensive information gathered on the organ before transplantation on immediate and long-term gra function. 15 In this work we monitor the degree of histopathological changes in the kidney aer storage in analyzed preservation solutions.…”

Section: Introductionmentioning

confidence: 99%

Application of analytical techniques to monitoring of kidney viability before transplantation during storage in ViaSpan® and Biolasol® Plus preservation solutions

et al. 2014

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In a porcine kidney transplant model, the effects of ViaSpan® and Biolasol® Plus solutions, as cellular preservation solutions, on graft function were compared. The retrieved porcine kidneys were flushed with either ViaSpan® or Biolasol® Plus solution and cold-stored for 72 h. In the analyzed tissue samples, the ADP/ATP ratio, Caspase-3 activity and DNA fragmentation were evaluated. The changes in the individual morphological finding were observed in pig kidneys preserved in both fluids. All the obtained data suggest that for short-term cold storage of kidney grafts (0 to 24 hours) Biolasol® Plus and ViaSpan® are equally effective, and indicate that porcine kidneys were best preserved in Biolasol® Plus solution for long-term storage (48 to 72 hours). Furthermore, there was no significant difference in the modes of cell death after storage in both of the preservation solutions.

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Assessment of Renal Graft Function Depending on Pre-Transplant Morphology

Cited by 4 publications

References 25 publications

Histopathological analysis of pre-implantation donor kidney biopsies: association with graft survival and function in one year post-transplantation

Histopathological analysis of pre-implantation donor kidney biopsies: association with graft survival and function in one year post-transplantation

Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients

Application of analytical techniques to monitoring of kidney viability before transplantation during storage in ViaSpan® and Biolasol® Plus preservation solutions

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