The evaluation of hepatobiliary disease continues to change as new technologies are introduced. One of the more recent advances in hepatobiliary imaging has been the application of endoscopic ultrasound (EUS). Endoscopic retrograde cholangiopancreatography, computed tomography, conventional ultrasound, and magnetic resonance imaging were previously the primary means of evaluating hepatobiliary disease. The role of EUS as both a substitute and a complement for these historical imaging modalities continues to evolve. This review examines the current literature on EUS in the evaluation of hepatobiliary diseases, including choledocholithiasis, microlithiasis, biliary strictures, obstructive jaundice, cholangiocarcinoma, gallbladder polyps, and liver lesions.