Assessment of right ventricular anatomy and function by quantitative radionuclide ventriculography

Ratner, Scott J.; Huang, Pang-Shuo; Friedman, Marvin; Pierson, Richard N.

doi:10.1016/0735-1097(89)90511-1

Cited by 32 publications

(8 citation statements)

References 15 publications

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“…Another study using cine-ventriculography reported that the group with DCM had a larger RV end-diastolic volume index, and higher RV end-diastolic and mean pulmonary artery pressures than the control group, 13 which differs from our results, probably because some of their cases with DCM were not taking medication or did not have a lower RVEF than LVEF despite there being no obvious sign of RV dysplasia in an endomyocardial biopsy. A study using first pass radionuclide angiography reported that the group with DCM with typical symptoms and signs of congestive heart failure had a larger RV end-systolic volume index and a lower RVEF than the control group, and that there were no significant differences in the RV end-diastolic volume index between the 2 groups, 14 which are comparable results to ours. We presume that differences in the degree of RV volume load (the level of preload in the RV) or the extent of RV myocardial damage underlie the differences in the results among the studies.…”

Section: Right Ventricular Volume In Dcmsupporting

confidence: 81%

Right Ventricular Systolic Function and the Manner of Transformation of the Right Ventricle in Patients With Dilated Cardiomyopathy

Oyama

Sakuma

Komaki

et al. 2004

Circ J

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ilated cardiomyopathy (DCM) is generally considered to be accompanied by both left and right ventricular dysfunction, 1,2 but in most studies only the function of the left ventricle (LV) has been analyzed, with less attention paid to the right ventricle (RV). One of the reasons is that the shape of the RV is complex and it is not easy to estimate RV volume and regional function. However, the RV ejection fraction (RVEF) is related to the capacity for exercise tolerance and to the prognosis in patients with severe LV failure such as an old myocardial infarction or dilated cardiomyopathy, 3-5 and therefore it is necessary to evaluate the RV function in such patients. Recently, we reported that RV angiography could be used to estimate the volume, ejection fraction (EF) and dimensional function of the chamber 6-9 and our aim in the present study was to examine the hemodynamics and dimensional function of the RV using this method in clinically well-controlled patients with DCM. Methods SubjectsTwenty-six patients underwent diagnostic catheterization: 13 (7 males, 6 females; mean age, 59.3 years (range, 16-75)) had chest pain and normal hemodynamics without Circulation Journal Vol. 68, October 2004 significant coronary artery stenosis, 13 (7 males, 6 females; mean age, 54.2 years (range, 22-73)) had DCM. DCM was diagnosed on the basis of exclusion of other causes of LV dysfunction, such as acute myocarditis, significant coronary artery stenosis, valvular disease and other secondary myocardial diseases. All patients were in normal sinus rhythm and New York Heart Association (NYHA) functional class II at catheter examination. Seven of the DCM patients had a past history of NYHA functional class IV. ProcedureRoutine left and right catheterization was performed using a standard technique. After LV cineangiography (right anterior oblique 30°) and coronary angiography, biplane RV cineangiography was performed with 35-mm cine film at a rate of 50 frames/s in a steep left anterior oblique view projection perpendicular to this projection using a Nishiya's catheter via the right femoral vein as previously reported. [6][7][8][9] We chose an angle for the left anterior oblique view in which the interventricular septum was seen best by biventriculography and in all patients it was 45°. In this projection, the 2 bent portions of the Nishiya's catheter appeared to overlap closely as if in a straight line. Shallow spontaneous breathing was permitted to avoid the Valsalva maneuver. Contrast medium (iopamidol 75.52%) was injected into the RV through the catheter at a rate of 12-13 ml/s for 3 s. Data AnalysisFrames from 1 cardiac cycle of the right ventriculogram from before the electrocardiographic P wave to behind the next P wave were analyzed. The RV silhouette on each frame of the biplane right ventriculogram was projected. Its Circ J 2004; 68: 933 -937 (Received April 26, 2004; revised manuscript received June 23, 2004; accepted July 6, 2004 Methods and ResultsBiplane right ventriculography was performed in 13 control subject...

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Section: Right Ventricular Volume In Dcmsupporting

confidence: 81%

Right Ventricular Systolic Function and the Manner of Transformation of the Right Ventricle in Patients With Dilated Cardiomyopathy

Oyama

Sakuma

Komaki

et al. 2004

Circ J

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“…Right ventricular regional wall motion has been assessed by cineangiography, 19-21 2-D echocardiography, 5,22 radionuclide angiography 23 and magnetic resonance imaging, 24 but none of these reports examined the direct relation between the right ventricular global ejection fraction and regional shortening. Our results suggest that the ejection function of the right ventricle can be evaluated to some degree by the % shortening of the SF dimension in cases without obvious regional wall motion abnormalities of the left ventricle or right ventricular overload.…”

Section: F-mp Distance From the Right Ventricular Free Wall To The Mmentioning

confidence: 99%

Right Ventricular Ejection Function Assessed by Cineangiography. Importance of Bellows Action.

Sakuma

Ishigaki

Komaki

et al. 2002

Circ J

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“…The ability to visualize both the right and left ventricles has proven difficult in prior studies using exercise radionuclide, echocardiographic and earlier CT imaging techniques [23][24][25]. Poor visualization of the right ventricle, a poorly defined endocardial surface, irregular right ventricular geometry, and limited reproducibility of exercise studies are important limitations of echocardiography in evaluating the left and right ventricle [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of Testosterone and Resistance Training on Cardiac Mass and Contractility in Men with COPD

Budoff¹,

Mao²,

Rambod³

et al. 2011

J Allergy Ther

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Introduction: Testosterone therapy and resistance training have been demonstrated to improve muscle mass and strength in patients with testosterone deficiency. However the effects on cardiac mass and contractility of these interventions have not been identified in prospective placebo-controlled trials. The hypothesis of this trial was that resistance training and testosterone replacement would improve cardiac mass and contractility in male COPD patients with low testosterone levels. Methods:We conducted a 10 week trial in a 2 by 2 factorial design, randomizing 53 patients to replacement doses of testosterone enanthate (100 mg weekly) or placebo, as well as to a program of lower extremity resistance training or no exercise. We performed rest and exercise cardiac computed tomography (CCT) studies before and after 10 weeks of therapy to evaluate right and left heart function. Patients were injected with 40-50 ml of non-ionic, iodinated contrast and cine CCT images were obtained at rest. Patients were exercised to 60% of their maximal work rate on a semi-supine ergometer, then re-injected with another bolus of 40-50 ml of contrast and re-imaged. We evaluated cardiac output and left ventricular (LV) and right ventricular (RV) mass, LV and RV stroke volume, ejection fractions and end-diastolic volumes at rest and exercise, before and after therapy.Results: 42 men with COPD (mean FEV 1 =40%pred. pre-bronchodilator) and low testosterone levels (mean=320ng/dl) completed the 10 week protocol. Factorial analysis demonstrated that testosterone, but not resistance training increased LV and RV mass (by 4.9% and 8.3%, respectively). Resistance training, but not testosterone, was associated with increased LV ejection fraction at rest and during exercise (by 5.5% and 4.4%, respectively). In the entire study group, increases in both left and right ventricular mass were correlated with increases in lean body mass (assessed by DEXA) (r=0.49 and r=0.65, respectively). Conclusions:In men with COPD, testosterone replacement and strength training are associated with distinct alterations in cardiac structure and function. Specifically, resistance training improved ejection fraction, while testosterone increased lean body mass and LV mass.

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Assessment of right ventricular anatomy and function by quantitative radionuclide ventriculography

Cited by 32 publications

References 15 publications

Right Ventricular Systolic Function and the Manner of Transformation of the Right Ventricle in Patients With Dilated Cardiomyopathy

Right Ventricular Systolic Function and the Manner of Transformation of the Right Ventricle in Patients With Dilated Cardiomyopathy

Right Ventricular Ejection Function Assessed by Cineangiography. Importance of Bellows Action.

Effect of Testosterone and Resistance Training on Cardiac Mass and Contractility in Men with COPD

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